29 recruiting, 26 active not recruiting, 9 completed, 5 not yet recruiting. 75 Phase 3, 17 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 562 | 2027-03-09 | 2026-10-13 |
| Testing the Investigational Medication Pembrolizumab After Kidney Removal for Patients With Non-Clear Cell Renal Cell Carcinoma Biospecimen Collection, Bone Scan, Computed Tomography - Non-Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 | Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 400 | 2027-02-10 | 2026-07-08 |
| Comparing Bispecific Antibody Treatment to Autologous Stem Cell Transplant for Newly Diagnosed, Standard Risk Multiple Myeloma Daratumumab and Recombinant Human Hyaluronidase, Lenalidomide, Bortezomib - Multiple Myeloma (MM) | Phase 2 / Phase 3 | Not yet recruiting | Alliance for Clinical Trials in Oncology | 920 | 2026-12-23 | 2026-10-22 |
| Evaluating the Addition of Maintenance Immunotherapy Compared to the Usual Treatment of Chemotherapy and Autologous Stem Cell Transplant Alone for High-risk Patients With Relapsed or Refractory Hodgkin Lymphoma 3-Dimensional Conformal Radiation Therapy, Autologous Hematopoietic Stem Cell Transplantation, Biospecimen Collection - Recurrent Classic Hodgkin Lymphoma, Refractory Classic Hodgkin Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 374 | 2026-12-04 | 2026-07-08 |
| Testing the Addition of a New Anti-Cancer Drug, Glofitamab to Usual Chemotherapy for Burkitt and Double Hit Lymphoma Biospecimen Collection, Bone Marrow Biopsy, Carboplatin - Recurrent Burkitt Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements | Phase 2 / Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 271 | 2026-10-30 | 2026-08-19 |
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial Anastrozole, Biospecimen Collection, Bone Scan - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 1978 | 2026-08-10 | 2026-10-30 |
| Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial Biospecimen Collection, Computed Tomography, Cyclophosphamide - Richter Syndrome, Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 102 | 2026-08-04 | 2026-10-13 |
| Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Advanced Head and Neck Cancer Who Cannot Receive Cisplatin Biospecimen Collection, Carboplatin, Cetuximab - Locally Advanced Hypopharyngeal Squamous Cell Carcinoma, Locally Advanced Laryngeal Squamous Cell Carcinoma | Phase 3 | Recruiting | NRG Oncology | 454 | 2026-07-31 | 2026-10-27 |
| A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Rhabdomyosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 342 | 2026-07-14 | 2026-08-25 |
| Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma Adjuvant Therapy, Comprehensive Geriatric Assessment, Computed Tomography - Cutaneous Melanoma | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 428 | 2026-04-17 | 2026-09-24 |
| Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial Atezolizumab, Bevacizumab, Biospecimen Collection - Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 226 | 2026-02-26 | 2026-08-17 |
| Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - CIC-Rearranged Sarcoma, Metastatic Ewing Sarcoma | Phase 2 / Phase 3 | Terminated | Children's Oncology Group | 2 | 2025-11-10 | 2026-10-05 |
| Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer Biospecimen Collection, Brachytherapy, Carboplatin - Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2025-11-05 | 2026-10-28 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-10-23 |
| Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Capecitabine - Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 356 | 2025-08-21 | 2026-08-25 |
| Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy Autologous Hematopoietic Stem Cell Transplantation, Best Practice, Biospecimen Collection - Anaplastic Large Cell Lymphoma, ALK-Negative, Follicular Helper T-Cell Lymphoma | Phase 3 | Recruiting | Eastern Cooperative Oncology Group | 294 | 2025-06-18 | 2026-09-14 |
| A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) Bone Scan, Carboplatin, Computed Tomography - Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor | Phase 3 | Recruiting | Children's Oncology Group | 1656 | 2025-04-15 | 2026-08-25 |
| Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment Biospecimen Collection, Cetuximab, Computed Tomography - Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 158 | 2025-03-27 | 2026-10-26 |
| Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma Biospecimen Collection, Bone Scan, Computed Tomography - Pleuropulmonary Blastoma | Phase 3 | Recruiting | Children's Oncology Group | 110 | 2025-03-21 | 2026-08-25 |
Showing 20 of 75. Sign in to see all of them.
Prostatic Neoplasms (13) · Lung Neoplasms (7) · Oropharyngeal Neoplasms (5) · Squamous Cell Carcinoma of Head and Neck (5) · Carcinoma (4) · Carcinoma, Non-Small-Cell Lung (4) · Mouth Neoplasms (4) · Disease (3) · Hypopharyngeal Neoplasms (3) · Laryngeal Neoplasms (3) · Multiple Myeloma (3) · Breast Neoplasms (2) · Burkitt Lymphoma (2) · Lymphoma, Large B-Cell, Diffuse (2) · Melanoma (2)
National Cancer Institute (NCI) (28) · NRG Oncology (13) · Children's Oncology Group (10) · ECOG-ACRIN Cancer Research Group (4) · SWOG Cancer Research Network (4) · Jonsson Comprehensive Cancer Center (3) · Mayo Clinic (3) · Alliance for Clinical Trials in Oncology (2) · Blue Earth Diagnostics (2) · Andrei Iagaru (1) · Avid Radiopharmaceuticals (1) · Eastern Cooperative Oncology Group (1) · Nantes University Hospital (1) · Ontario Clinical Oncology Group (OCOG) (1) · Tata Memorial Hospital (1)
United States (66) · Canada (26) · Puerto Rico (11) · Australia (9) · Hong Kong (3) · New Zealand (3) · Finland (2) · Ireland (2) · Netherlands (2) · Saudi Arabia (2) · Singapore (2) · Switzerland (2) · China (1) · France (1) · Germany (1)
Jeremie Calais (2) · Vaishalee P Kenkre (2) · Aarti Bhatia (1) · Alex F Herrera (1) · Andrei Iagaru (1) · Bhuvana A Setty (1) · Carlos E. Vargas, MD (1) · Charles B Simone (1) · Christine M Bestvina (1) · Christine M Heske (1) · Claire Holloway, MD (1) · Daniel Morgensztern, MD (1) · David J Sher (1)
PMID 37505794, PMID 38421243, PMID 41698328, PMID 28686535, PMID 29242398, PMID 29242404, PMID 30616601, PMID 30920593, PMID 31253621, PMID 31375469, PMID 32338734, PMID 32542468, PMID 32808077, PMID 33006656, PMID 33151787, PMID 33288485, PMID 33386288, PMID 33843815, PMID 33962579, PMID 34028986, PMID 34406051, PMID 34634256, PMID 34686472, PMID 35613998, PMID 36416836, PMID 36485104, PMID 37414702, PMID 38107263, PMID 38664019, PMID 38782456, PMID 38945791, PMID 38947228, PMID 39413375, PMID 39615497, PMID 39938471, PMID 41005671, PMID 41137728, PMID 41512237, PMID 41671459, PMID 41671463, PMID 41747891, PMID 41911908, PMID 42224490, PMID 42497367, PMID 42525921, PMID 42526889, PMID 42577949, PMID 42660130, PMID 42702214
U10CA180868 (18), U10CA180820 (17), U10CA180886 (12), U10CA180888 (9), U10CA180821 (4), U10CA021661 (1), U10CA180822 (1)