18 completed. 18 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 18 |
| Phase 2 | 3 | Completed 3 |
Follow perifosine: new trials by email Literature Review of perifosine trials Research Report on perifosine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas Cytoreductive surgery, Perifosine, Temsirolimus - Brain Tumor, Recurrent, Glioblastoma | Phase 1 | Completed | Andrew B Lassman, MD | 10 | 2014-12-08 | 2023-05-25 |
| A Food Effect and QTc Study of Perifosine in Patients With Advanced Malignancies perifosine - Cancer | Phase 1 | Completed | AEterna Zentaris | 24 | 2012-01-24 | 2018-03-14 |
| Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma Laboratory Biomarker Analysis, Perifosine, Temsirolimus - Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 36 | 2010-01-27 | 2021-07-19 |
| Perifosine With Temsirolimus for Recurrent Pediatric Solid Tumors perifosine + temsirolimus - Pediatric Solid Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 23 | 2010-01-01 | 2017-03-10 |
| Study of Perifosine + Capecitabine for Colon Cancer Patients Perifosine, Capecitabine - Colon Cancer | Phase 1 | Completed | AEterna Zentaris | 10 | 2009-10-01 | 2018-06-28 |
| Study of Single Agent Perifosine for Recurrent Pediatric Solid Tumors perifosine - Solid Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 38 | 2008-10-01 | 2017-08-01 |
| Perifosine and Docetaxel in Patients With Relapsed Epithelial Ovarian Cancer Perifosine, Docetaxel - Ovarian Cancer | Phase 1 | Completed | M.D. Anderson Cancer Center | 22 | 2007-02-01 | 2016-02-19 |
| Phase I Study of Perifosine + Lenalidomide and Dexamethasone for Patients With Multiple Myeloma Perifosine, Lenalidomide, Dexamethasone - Multiple Myeloma | Phase 1 | Completed | AEterna Zentaris | 32 | 2006-12-01 | 2012-07-06 |
| Perifosine + Sunitinib Malate for Patients With Advanced Cancers Perifosine, Sunitinib Malate - Renal Cancer, GIST | Phase 1 | Completed | AEterna Zentaris | 15 | 2006-10-01 | 2014-02-19 |
| Phase I Study of Perifosine + Sorafenib for Patients With Advanced Cancers Perifosine, Sorafenib - Renal Cancer, Tumors | Phase 1 | Completed | AEterna Zentaris | 30 | 2006-10-01 | 2014-02-19 |
| Safety & Efficacy Study of Perifosine + Bortezomib +/- Dexamethasone for Multiple Myeloma Patients Perifosine, Bortezomib, Dexamethasone - Multiple Myeloma, Multiple Myeloma in Relapse | Phase 1 / Phase 2 | Completed | AEterna Zentaris | 84 | 2006-08-01 | 2018-02-23 |
| 7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes 7-hydroxystaurosporine, perifosine, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Megakaryoblastic Leukemia (M7) | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2005-12-01 | 2013-09-30 |
| Phase I Trial of Docetaxel With Perifosine Perifosine, Docetaxel, Prednisone - Neoplasms | Phase 1 | Completed | AEterna Zentaris | 39 | 2004-11-01 | 2014-02-13 |
| Phase I Trial of Paclitaxel With Perifosine Perifosine, Paclitaxel - Neoplasms | Phase 1 | Completed | AEterna Zentaris | 24 | 2004-11-01 | 2014-02-13 |
| A Phase 1/2 Trial of Perifosine in the Treatment of Non-Small Cell Lung Cancer Perifosine - Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | AEterna Zentaris | 121 | 2004-09-01 | 2018-02-22 |
| Phase I Perifosine and Gemcitabine Study Perifosine, Gemcitabine - Neoplasms | Phase 1 | Completed | AEterna Zentaris | 19 | 2004-08-01 | 2014-02-13 |
| Perifosine in Treating Patients With Advanced Solid Tumors perifosine - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | University of Wisconsin, Madison | 2000-02-01 | 2019-12-13 | |
| Perifosine in Treating Patients With Refractory Solid Tumors or Hematologic Cancer perifosine - Leukemia, Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 1999-08-01 | 2015-04-29 |
Neoplasms (5) · Astrocytoma (2) · Brain Neoplasms (2) · Glioblastoma (2) · Glioma (2) · Kidney Neoplasms (2) · Multiple Myeloma (2) · Myelodysplastic-Myeloproliferative Diseases (2) · Oligodendroglioma (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Recurrence (2) · Blast Crisis (1) · Burkitt Lymphoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Colonic Neoplasms (1)
AEterna Zentaris (10) · National Cancer Institute (NCI) (3) · Memorial Sloan Kettering Cancer Center (2) · Andrew B Lassman, MD (1) · M.D. Anderson Cancer Center (1) · University of Wisconsin, Madison (1)
United States (14)
Ira Dunkel, MD (2) · Andrew B. Lassman, MD (1) · Andrzej J Jakubowiak, MD, PhD (1) · David S. Hong, MD (1) · David Spigel, MD (1) · Ed Cullen, PhD (1) · Edward A. Sausville, MD, PhD (1) · Ivana Gojo (1) · Johanna Bendell,, MD (1) · Lynn Van Ummersen, MD (1) · Paul Richardson, MD (1) · Robert Birch, Ph.D. (1) · Thomas J Kaley (1)
PMID 22419878, PMID 21990396, PMID 22640031, PMID 23443507, PMID 27649927
P30CA008748 (1), P30CA014520 (1), U01CA069856 (1)