9 completed. 9 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 9 |
| Phase 2 | 6 | Completed 6 |
Follow Pentoxifylline: new trials by email Literature Review of Pentoxifylline trials Research Report on Pentoxifylline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Pentoxifylline for Treatment of Resistant Major Depression Pentoxifylline, Placebo - Resistant Major Depression | Phase 1 / Phase 2 | Completed | Hawler Medical University | 60 | 2021-12-15 | 2022-09-07 |
| Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder Citalopram (tablet) 20 mg + Pentoxifylline (tablet) 400Mg, Citalopram (tablet) 20 mg + Placebo (tablet) - Major Depressive Disorder | Phase 1 / Phase 2 | Completed | Hawler Medical University | 100 | 2021-11-10 | 2022-09-07 |
| Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia Placebo oral tablet, Pentoxifylline - Schizophrenia | Phase 1 / Phase 2 | Completed | Sadat City University | 80 | 2019-01-01 | 2022-10-25 |
| Study to Evaluate the PK of Single and Optional Multiple Dosing Regimens of MR Formulations of PCS499 Compared to Trental® Administered to Healthy Subjects PCS499, Trental - Healthy | Phase 1 | Completed | Processa Pharmaceuticals | 18 | 2018-02-26 | 2019-02-12 |
| Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy Pentoxifylline - Muscular Dystrophy, Duchenne | Phase 1 / Phase 2 | Completed | Cooperative International Neuromuscular Research Group | 64 | 2005-09-01 | 2011-10-27 |
| Pentoxifylline in Duchenne Muscular Dystrophy Pentoxifylline - Muscular Dystrophy, Duchenne | Phase 1 / Phase 2 | Completed | Cooperative International Neuromuscular Research Group | 17 | 2002-03-01 | 2011-10-27 |
| Radiation Therapy in Treating Patients With Glioblastoma chemotherapy, hydroxyurea, pentoxifylline - Brain and Central Nervous System Tumors | Phase 1 | Completed | National Cancer Institute (NCI) | 34 | 1995-04-01 | 2015-04-29 |
| Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS Pentoxifylline - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 54 | 2021-11-02 |
Muscular Dystrophy, Duchenne (2) · Acquired Immunodeficiency Syndrome (1) · Bipolar Disorder (1) · Cachexia (1) · Camurati-Engelmann Syndrome (1) · Central Nervous System Neoplasms (1) · Depressive Disorder, Major (1) · Glioblastoma (1) · Gliosarcoma (1) · HIV Infections (1) · Muscular Dystrophies (1) · Oral Submucous Fibrosis (1) · Schizophrenia (1)
Cooperative International Neuromuscular Research Group (2) · Hawler Medical University (2) · National Cancer Institute (NCI) (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Processa Pharmaceuticals (1) · Sadat City University (1) · Ziauddin University (1)
United States (4) · Iraq (2) · Argentina (1) · Australia (1) · Canada (1) · Egypt (1) · Israel (1) · Italy (1) · Pakistan (1) · United Kingdom (1)
Diana Escolar, MD (2) · Talar A Merzamohammad, Pharm. D (2) · Brian G. Fuller, MD (1) · Crumpacker C (1) · Dezube B (1) · Sharan Sidhu, MBChB (1)
PMID 28390753, PMID 31472446, PMID 33008091, PMID 34007848, PMID 35410255, PMID 36341700, PMID 36552855