20 completed, 6 terminated, 3 withdrawn, 1 recruiting. 18 Phase 1, 11 Phase 2, 2 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 12, Terminated 5, Withdrawn 1 |
| Phase 2 | 11 | Completed 7, Terminated 2, Recruiting 1, Withdrawn 1 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow O6-benzylguanine: new trials by email Literature Review of O6-benzylguanine trials Research Report on O6-benzylguanine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) P140K-MGMT, O6-benzylguanine, Photon Based Radiotherapy - Glioblastoma Multiforme, Glioblastoma Multiforme, Adult | Phase 2 | Recruiting | Leland Metheny | 16 | 2023-01-20 | 2026-09-10 |
| HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs, Carmustine, Filgrastim - Human Immunodeficiency Virus 1 Positive, Stage I Adult Hodgkin Lymphoma | Phase 1 | Withdrawn | Fred Hutchinson Cancer Center | 2016-08-15 | 2018-11-20 | |
| Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma carmustine, cytarabine, melphalan - Adult Nasal Type Extranodal NK/T-cell Lymphoma, AIDS-related Diffuse Large Cell Lymphoma | Not applicable | Withdrawn | Fred Hutchinson Cancer Center | 2015-02-01 | 2015-05-07 | |
| BG & TMZ Therapy of Glioblastoma Multiforme MGMTP140K-encoding retroviral vector, O6-benzylguanine, temozolomide - Glioblastoma Multiforme | Phase 1 | Completed | Stanton Gerson MD | 10 | 2011-11-22 | 2023-03-02 |
| O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma Carmustine, Laboratory Biomarker Analysis, O6-Benzylguanine - Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma, Stage I Mycosis Fungoides and Sezary Syndrome AJCC v7 | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 17 | 2010-02-01 | 2018-05-22 |
| O6-Benzylguanine-Mediated Tumor Sensitization With Chemoprotected Autologous Stem Cell in Treating Patients With Malignant Gliomas 3-Dimensional Conformal Radiation Therapy, Autologous Hematopoietic Stem Cell Transplantation, Carmustine - Glioblastoma, Gliosarcoma | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 12 | 2009-02-25 | 2022-05-18 |
| O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy O6-benzylguanine, temozolomide - Brain and Central Nervous System Tumors | Phase 2 | Terminated | National Cancer Institute (NCI) | 12 | 2006-11-13 | 2017-03-28 |
| O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors O6-benzylguanine, temozolomide - Brain and Central Nervous System Tumors | Phase 2 | Completed | National Cancer Institute (NCI) | 41 | 2006-02-01 | 2022-02-11 |
| Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas O6-benzylguanine, busulfan, temozolomide - Brain and Central Nervous System Tumors | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 2005-08-01 | 2014-01-06 | |
| Ph I 5-day Temozolomide + O6-BG in Treatment of Pts w Recurrent / Progressive GBM Temodar and O6-Benzylguanine - Glioblastoma, Gliosarcoma | Phase 1 | Completed | Duke University | 42 | 2005-02-01 | 2014-07-16 |
| Ifosfamide With or Without O(6)-Benzylguanine in Treating Patients With Unresectable, Metastatic Solid Tumors ifosfamide, O6-benzylguanine - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Terminated | National Cancer Institute (NCI) | 32 | 2004-06-01 | 2013-01-24 |
| Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma O6-benzylguanine, polifeprosan 20 with carmustine implant, adjuvant therapy - Brain and Central Nervous System Tumors | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 3 | 2003-03-01 | 2009-10-16 |
| Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors O6-benzylguanine, temozolomide, filgrastim - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2002-10-01 | 2013-09-30 |
| S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma carmustine, radiation therapy, O6-Benzylguanine - Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System | Phase 3 | Completed | SWOG Cancer Research Network | 183 | 2001-09-01 | 2013-01-30 |
| Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma O6-benzylguanine, temozolomide, conventional surgery - Brain and Central Nervous System Tumors | Phase 1 | Completed | Duke University | 2001-03-01 | 2013-06-20 | |
| Carmustine Plus O6-benzylguanine in Treating Patients With Recurrent or Progressive Glioma O6-benzylguanine, carmustine - Brain and Central Nervous System Tumors | Phase 2 | Completed | Duke University | 2000-08-01 | 2014-08-21 | |
| Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer O6-benzylguanine, carmustine - Colorectal Cancer | Phase 2 | Completed | Case Comprehensive Cancer Center | 13 | 2000-06-01 | 2010-06-10 |
| Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors O6-benzylguanine, temozolomide - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 2000-06-01 | 2015-04-29 | |
| O6-benzylguanine and Carmustine in Treating Patients With Unresectable Locally Recurrent or Metastatic Melanoma O6-benzylguanine, carmustine - Melanoma (Skin) | Phase 2 | Completed | National Cancer Institute (NCI) | 40 | 2000-06-01 | 2013-02-11 |
| O6-benzylguanine and Carmustine in Treating Patients With Recurrent, Metastatic, or Locally Advanced Soft Tissue Sarcoma O6-benzylguanine, carmustine - Sarcoma | Phase 2 | Completed | University of Chicago | 12 | 2000-06-01 | 2013-09-05 |
Showing 20 of 30. Sign in to see all of them.
Glioblastoma (14) · Central Nervous System Neoplasms (13) · Gliosarcoma (13) · Astrocytoma (11) · Brain Neoplasms (8) · Oligodendroglioma (6) · Glioma (5) · Choroid Plexus Neoplasms (3) · Familial ependymoma (3) · Lymphoma, Non-Hodgkin (3) · Lymphoma, T-Cell, Cutaneous (3) · Medulloblastoma (3) · Optic Nerve Glioma (3) · Burkitt Lymphoma (2) · Ependymoma (2)
National Cancer Institute (NCI) (10) · Duke University (5) · Case Comprehensive Cancer Center (4) · Fred Hutchinson Cancer Center (3) · University of Chicago (2) · Children's Hospital Medical Center, Cincinnati (1) · Leland Metheny (1) · Pediatric Brain Tumor Consortium (1) · SWOG Cancer Research Network (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Stanton Gerson MD (1)
United States (28) · Australia (1) · Canada (1)
Henry S. Friedman, MD (4) · Katherine Warren, MD (2) · Kevin Cooper (2) · Stanton L. Gerson, MD (2) · Alexander M. Spence, MD (1) · Amar Gajjar (1) · Andrew Sloan, MD (1) · Ann Woolfrey (1) · David A. Reardon, MD (1) · Deborah T. Blumenthal, MD (1) · Denise Adams, MD (1) · Hans-Peter Kiem (1) · Howard A Fine, M.D. (1) · Ian F. Pollack, MD (1) · James KV Willson, MD (1)
PMID 16033132, PMID 16192602, PMID 16234526, PMID 17264335, PMID 17941066, PMID 19289491, PMID 19430790, PMID 22250189, PMID 25105369, PMID 25407559, PMID 28199478
U01CA062502 (5), P30CA043703 (4), P30CA015704 (2), R01HL116217 (1), R21CA076192 (1), R21CA115057 (1), U01CA063200 (1), U01CA069852 (1), U01CA081457 (1), U01CA236215 (1), U10CA032102 (1)