7 not yet recruiting, 6 completed, 3 unknown, 1 recruiting. 8 Not applicable, 4 Phase 1, 3 Phase 2, 3 Phase 4, 2 Phase 3.
Follow Normal Saline (NS): new trials by email Literature Review of Normal Saline (NS) trials Research Report on Normal Saline (NS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Probiotic Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis heat-killed probiotic LDL557 (Lactobacillus delbrueckii subsp. lactis LDL557), Normal Saline (NS) - Sinusitis Chronic, Postoperative Care | Not applicable | Not yet recruiting | Taichung Veterans General Hospital | 120 | 2026-10-31 | 2026-10-08 |
| Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy Combined Bupivacaine and Exparel, Normal Saline (NS) - Pain, Postoperative | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center, Houston | 104 | 2026-09-17 | 2026-09-25 |
| Magnesium Sulfate With Standard Combined Costoclavicular-Suprascapular Block for Pain Relief After Shoulder Arthroscopy. Bupivacaine, Magnesium sulfate (MgSO4), Normal Saline (NS) - Shoulder Arthroscopy, Postoperative Pain | Not applicable | Not yet recruiting | Assiut University | 84 | 2026-09-01 | 2026-09-01 |
| Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients Dezocine, Normal Saline (NS) - Postoperative Delirium (POD) | Not applicable | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 640 | 2026-09-01 | 2026-08-17 |
| A Study on the Preventive Effect of Electroacupuncture Combined With Dexmedetomidine in Post-stroke Depression Dexmedetomidine, Electropuncture, Normal Saline (NS) - Post-stroke Depression | Phase 4 | Not yet recruiting | Min Su | 231 | 2026-08-01 | 2026-07-31 |
| Local Hyperthermia Combined With Topical 3% Hydrogen Peroxide for Refractory Viral Warts An infrared hyperthermia device, Hydrogen Peroxide 3 % Topical Solution, Normal Saline (NS) - Refactory Warts | Not applicable | Recruiting | First Hospital of China Medical University | 80 | 2025-10-01 | 2026-05-04 |
| Intravesical Hyaluronic Acid (HA) for Preventing Radiation Cystitis on Bladder Cancer Blad-Care (sodium hyaluronate 1.6%, 800 mg/50 mL, BioPlus Co., Ltd.), Normal Saline (NS) - Bladder Cancer, Radiation Cystitis | Not applicable | Not yet recruiting | National Cancer Center, Korea | 54 | 2025-08-22 | 2025-08-15 |
| Efficacy of Stromal Vascular Fraction on Acne Scar Correction stromal vascular fraction (SVF), Normal Saline (NS) - Acne Scars, Acne Scars - Atrophic | Not applicable | Not yet recruiting | Seoul National University Hospital | 16 | 2025-07-01 | 2025-07-31 |
| Hyaluronidase Assisted Subcutaneous Infusion hyaluronidase, Placebo - Healthy | Phase 3 | Completed | Shanghai Bao Pharmaceuticals Co., Ltd. | 45 | 2024-03-28 | 2024-09-23 |
| The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery Lidocaine, Normal saline (NS) - Cervical Cancer, Metastatic Cancer | Not applicable | Unknown | General Hospital of Ningxia Medical University | 60 | 2022-12-01 | 2022-09-29 |
| Povidone-Iodine for Nasal Decolonization Povidone-Iodine 10%, 0.9% NaCl Solution - Surgical Wound Infection, Preoperative Care | Phase 4 | Completed | Rutgers, The State University of New Jersey | 192 | 2022-09-06 | 2024-11-13 |
| The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients Lidocaine, Normal saline (NS) - Organ Protection | Not applicable | Unknown | General Hospital of Ningxia Medical University | 50 | 2022-09-01 | 2022-08-16 |
| VA CoronavirUs Research and Efficacy Studies-1 Convalescent Plasma, Masked Saline Placebo - COVID-19 | Phase 3 | Terminated | VA Office of Research and Development | 75 | 2020-11-16 | 2022-09-23 |
| Efficacy of Coadministration of Calcitonin and Hyperbaric Bupivacaine in Spinal Anesthesia in Tramadol-abuse Patients Calcitonin presented as Miacalcic® ampoules 100 IU/ml (1ml) intrathecally, Calcitonin presented as Miacalcic® ampoules 100 IU/ml (1ml) intravenously, Normal Saline (NS) - Analgesia | Phase 4 | Completed | Ain Shams University | 90 | 2020-09-01 | 2025-04-08 |
| Fecal Microbiota Transplantation (FMT) for Severe Acute Pancreatitis(SAP) Fecal Microbiota Transplantation, normal saline - Acute Pancreatitis, Intestinal Bacteria Flora Disturbance | Phase 1 / Phase 2 | Unknown | First Affiliated Hospital of Chengdu Medical College | 80 | 2016-12-01 | 2017-01-11 |
| Dose-Related Inflammatory Effects of Intravenous Endotoxin in Humans Endotoxin, Placebo - Healthy | Phase 1 | Completed | Robert J Noveck, M.D. | 23 | 2016-08-01 | 2017-04-11 |
| Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis PfSPZ Challenge, Normal Saline (NS) - Malaria, Plasmodium Falciparum | Phase 1 | Completed | Sanaria Inc. | 30 | 2012-09-01 | 2017-05-15 |
| IV Glucose for Dehydration Treatment 5% Dextrose (D5) in Normal Saline (NS), Normal Saline (NS) - Dehydration | Phase 2 | Completed | Children's Hospital of Philadelphia | 83 | 2010-09-01 | 2019-03-19 |
Pain, Postoperative (2) · Agnosia (1) · COVID-19 (1) · Dehydration (1) · Disease Progression (1) · Emergence Delirium (1) · Gastroenteritis (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Hyperthermia (1) · Malaria (1) · Malaria, Falciparum (1) · Neoplasm Metastasis (1) · Pancreatitis (1) · Pneumonia (1) · Postoperative Cognitive Complications (1)
General Hospital of Ningxia Medical University (2) · Ain Shams University (1) · Assiut University (1) · Children's Hospital of Philadelphia (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · First Affiliated Hospital of Chengdu Medical College (1) · First Hospital of China Medical University (1) · Min Su (1) · National Cancer Center, Korea (1) · Robert J Noveck, M.D. (1) · Rutgers, The State University of New Jersey (1) · Sanaria Inc. (1) · Seoul National University Hospital (1) · Shanghai Bao Pharmaceuticals Co., Ltd. (1) · Taichung Veterans General Hospital (1)
United States (5) · China (4) · Egypt (2) · Netherlands (1) · Puerto Rico (1) · South Korea (1) · Taiwan (1)
Alex Bekker, MD/PhD (1) · Asha B Bhalwal, MD (1) · Edward N. Janoff, MD (1) · Elizabeth R Alpern, MD (1) · Eman Ahmed Ismail, professor (1) · Kari Posner, MD (1) · Li Fang, Ph.D (1) · Mohamed Mohamed Abdel Latif, professor (1) · Mohamed Talaat Mohamed, Lecturer (1) · Robert J Noveck, MD, PhD (1) · Robert Sauerwein, MD (1) · Rong-San Jiang, MD, PhD (1) · Sung Uk Lee, MD, PhD (1)
PMID 22367348, PMID 28619097, PMID 29344322, PMID 34812859, PMID 35229691, PMID 37560085, PMID 38213639, PMID 40400480, PMID 41413319, PMID 41896726, PMID 41935547