6 completed, 2 active not recruiting, 2 recruiting. 3 Not applicable, 3 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Active not recruiting 2, Recruiting 1 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow NOAC: new trials by email Literature Review of NOAC trials Research Report on NOAC
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Single-stage Pulmonary Vein Isolation Combined With Percutaneous Left Atrial Appendage Occluder Implantation in Patients With Recent Onset Ischemic Stroke and Atrial Fibrillation PVI + LAAO, single stage, LAAO, NOAC - Ischemic Stroke, Atrial Fibrillation | Phase 4 | Recruiting | Medical University of Silesia | 240 | 2025-10-31 | 2026-04-13 |
| CHAMPION-AF Clinical Trial WATCHMAN FLX LAAC Device, Non-Vitamin K Oral Anticoagulant - Atrial Fibrillation, Stroke | Not applicable | Active not recruiting | Boston Scientific Corporation | 3000 | 2020-10-15 | 2026-10-14 |
| Amplatzer Amulet LAAO vs. NOAC Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Non-Vitamin K Oral Antagonists - Atrial Fibrillation, Stroke | Not applicable | Active not recruiting | Abbott Medical Devices | 2650 | 2020-07-07 | 2026-02-10 |
| Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation Left atrial appendage occlusion, NOAC - Atrial Fibrillation, Stroke | Not applicable | Recruiting | University of Aarhus | 750 | 2019-01-01 | 2023-12-21 |
| Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement NOAC, DAPT - Aortic Valve Stenosis | Phase 4 | Completed | Duk-Woo Park, MD | 235 | 2018-03-15 | 2021-11-08 |
| The Greek AntiPlatElet Atrial Fibrillation Registry. VKA, NOAC - Atrial Fibrillation, Coronary Artery Disease | Completed | Attikon Hospital | 654 | 2017-12-01 | 2021-07-26 | |
| This Study Observes the Use of New Oral Anticoagulants (NOACs) in Patients With a Heart Rhythm Disorder in Spain NOAC - Atrial Fibrillation | Completed | Boehringer Ingelheim | 1008 | 2017-11-29 | 2020-02-18 | |
| The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants Novel Oral Anti-Coagulants - Pleural Effusion, Thoracic Effusion | Completed | Yale University | 590 | 2017-10-30 | 2023-10-13 | |
| NOACs for Stroke Prevention in Patients With Atrial Fibrillation and Previous ICH NOAC, Acetylsalicylic Acid - Atrial Fibrillation, Intracerebral Hemorrhage | Phase 2 | Completed | Population Health Research Institute | 30 | 2017-04-26 | 2020-03-20 |
| Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in Atrial Fibrillation NOAC, Left atrial appendage closure - Atrial Fibrillation | Phase 4 | Completed | Charles University, Czech Republic | 400 | 2015-10-13 | 2021-06-11 |
Atrial Fibrillation (8) · Stroke (4) · Hemorrhage (2) · Aortic Valve Stenosis (1) · Cerebral Hemorrhage (1) · Coronary Artery Disease (1) · Ischemic Stroke (1) · Pleural Effusion (1)
Abbott Medical Devices (1) · Attikon Hospital (1) · Boehringer Ingelheim (1) · Boston Scientific Corporation (1) · Charles University, Czech Republic (1) · Duk-Woo Park, MD (1) · Medical University of Silesia (1) · Population Health Research Institute (1) · University of Aarhus (1) · Yale University (1)
Canada (3) · Denmark (3) · Germany (3) · Poland (3) · Spain (3) · United States (3) · Australia (2) · Czechia (2) · France (2) · Hong Kong (2) · Italy (2) · Japan (2) · Netherlands (2) · Switzerland (2) · United Kingdom (2)
Ashkan Shoamanesh, MD FRCPC (1) · Dimitrios Alexopoulos, MD (1) · Dorte Damgaard, MD PhD (1) · Jens Erik Nielsen-Kudsk, MD DMSc Prof (1) · Kasper Korsholm, MD (1) · Kenneth A Ellenbogen, MD (1) · Kyle Bramley, MD (1) · Maciej T. Wybraniec, MD, PhD, Professor (1) · Marty Leon, MD (1) · Mireia Canals, +34607550925 (1) · Saibal Kar, MD (1) · Seung-jung Park, MD (1) · Shephal Doshi, MD (1) · Vivek Reddy, MD (1)
PMID 10753982, PMID 15313941, PMID 15842354, PMID 16765759, PMID 19683639, PMID 19717844, PMID 21309657, PMID 21830957, PMID 21870978, PMID 22497820, PMID 23273528, PMID 23325525, PMID 23500276, PMID 23583249, PMID 23973952, PMID 32586585, PMID 33034806, PMID 33402409, PMID 34748929, PMID 35373583, PMID 36410034, PMID 36700520, PMID 37279840, PMID 37586823, PMID 38151311, PMID 40816554, PMID 41357284, PMID 41638386, PMID 41910347, PMID 7829800, PMID 8721656, PMID 9809895