13 completed, 8 recruiting, 3 unknown, 3 withdrawn. 27 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 27 | Completed 13, Recruiting 8, Unknown 3, Withdrawn 3 |
Follow Nitrofurantoin: new trials by email Literature Review of Nitrofurantoin trials Research Report on Nitrofurantoin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prophylactic Antibiotics for Outpatient Urethral Bulking Bactrim (800/160 mg), Keflex (500 mg), Cipro (250 mg), or Macrobid (100mg) - Urinary Tract Infections, Stress Urinary Incontinence | Phase 4 | Recruiting | University of Miami | 150 | 2026-08-19 | 2026-10-29 |
| Assessing the Utility of Prophylactic Antibiotics at Time of Urethral Bulking Using Bulkamid (Bulkamid Study) Bactrim or Macrobid, Placebo - Stress Urinary Incontinence | Phase 4 | Recruiting | Ohio State University | 138 | 2025-09-15 | 2026-10-13 |
| Microbiome-Modulating Prophylaxis RCT: Antibiotic vs Gynoflor in Postmenopausal Women With Recurrent Cystitis Nitrofurantoin, Gynoflor - Cystitis, Recurrent, Urinary Tract Infections | Phase 4 | Recruiting | Mahidol University | 100 | 2025-09-11 | 2025-09-25 |
| Intravesical Gentamicin to Prevent Recurrent UTI Gentamicin, Nitrofurantoin - Recurrent Uti | Phase 4 | Completed | Women and Infants Hospital of Rhode Island | 20 | 2025-04-28 | 2026-04-15 |
| Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis Pivmecillinam, Amoxicillin clavulanic acid, Amoxicillin - Cystectomy, Bladder Cancer Requiring Cystectomy | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 248 | 2025-01-07 | 2025-01-09 |
| COMPARISON OF NITROFURANTOIN WITH FOSFOMYCIN in TREATING CYSTITIS IN WOMEN Nitrofurantoin 100 MG, Fosfomycin - Urinary Tract Infections | Phase 4 | Unknown | Shalamar Institute of Health Sciences | 392 | 2025-01-01 | 2024-07-24 |
| Bladder Botox UTI Antibiotic Prophylaxis Nitrofurantoin 100 MG - Overactive Bladder, Bladder Pain Syndrome | Phase 4 | Recruiting | Walter Reed National Military Medical Center | 100 | 2024-04-04 | 2025-02-19 |
| Role of Prophylactic Postoperative Antibiotics in HoLEP Nitrofurantoin, Cephalexin, Sulfamethoxazole Trimethoprim Combination - Benign Prostatic Hyperplasia, Urinary Tract Infections | Phase 4 | Withdrawn | Baylor Research Institute | 2023-03-01 | 2026-02-12 | |
| Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study Ialuril 50ml Prefill, Nitrofurantoin - Recurrent Urinary Tract Infection | Phase 4 | Recruiting | Radboud University Medical Center | 100 | 2022-10-20 | 2024-11-18 |
| Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA Nitrofurantoin - Antibiotic Prophylaxis | Phase 4 | Recruiting | Atlantic Health System | 140 | 2022-08-16 | 2024-03-27 |
| The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste Nitrofurantoin, Double Antibiotic - Pain, Symptomatic Irreversible Pulpitis | Phase 4 | Completed | Altamash Institute of Dental Medicine | 60 | 2022-08-01 | 2022-10-31 |
| NextGen - Clinical Implication of Next Generation Sequencing Antibiotic, Next Gen - Urinary Tract Infections | Phase 4 | Recruiting | Wake Forest University Health Sciences | 100 | 2022-05-17 | 2025-12-08 |
| Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women. Fosfomycin Trometamol Salt, Nitrofurantoin, Pivmecillinam - Urinary Tract Infections | Phase 4 | Completed | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | 1000 | 2021-11-02 | 2025-09-08 |
| Comparison of Nitrofurantoin and Calcium Hydroxide as Intracanal Medicaments in Alleviating Post-operative Pain Nitrofurantoin 100 MG - Pain, Postoperative, Irreversible Pulpitis | Phase 4 | Completed | Altamash Institute of Dental Medicine | 60 | 2021-01-01 | 2021-05-25 |
| Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy Clindamycin, Diary, Ertapenem - Bladder Carcinoma, Refractory Bladder Carcinoma | Phase 4 | Completed | Roswell Park Cancer Institute | 89 | 2020-09-02 | 2026-09-29 |
| Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery Nitrofurantoin 100 MG, Placebo Oral Tablet - Catheter-Associated Urinary Tract Infection | Phase 4 | Completed | Wake Forest University Health Sciences | 164 | 2017-09-29 | 2022-08-09 |
| INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI Nitrofurantoin, Gentamicin - Urinary Tract Infections | Phase 4 | Withdrawn | Mayo Clinic | 2017-06-28 | 2019-06-06 | |
| Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery Nitrofurantoin, Placebo - Pelvic Organ Prolapse | Phase 4 | Completed | Halina M Zyczynski, MD | 154 | 2016-08-01 | 2019-05-29 |
| Struvite Stones Antibiotic Study ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin - Kidney Stones | Phase 4 | Unknown | University of British Columbia | 28 | 2015-03-01 | 2022-05-17 |
| A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL]) nitrofurantoin monohydrate/macrocrystalline capsules, ampicillin, gentamicin - Nephrolithiasis, Urinary Tract Infections | Phase 4 | Completed | University of California, San Diego | 86 | 2015-03-01 | 2019-08-22 |
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Urinary Tract Infections (19) · Cystitis (3) · Urinary Incontinence, Stress (3) · Infections (2) · Pelvic Organ Prolapse (2) · Recurrence (2) · Calculi (1) · Cystitis, Interstitial (1) · Kidney Calculi (1) · Lower Urinary Tract Symptoms (1) · Nephrolithiasis (1) · Pain (1) · Pain, Postoperative (1) · Prolapse (1) · Prostatic Hyperplasia (1)
Altamash Institute of Dental Medicine (2) · Wake Forest University Health Sciences (2) · Atlantic Health System (1) · Baylor Research Institute (1) · Copenhagen University Hospital, Rigshospitalet (1) · Duke University (1) · Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina (1) · HaEmek Medical Center, Israel (1) · Halina M Zyczynski, MD (1) · Mahidol University (1) · Mayo Clinic (1) · Mepha Ltd. (1) · Newcastle-upon-Tyne Hospitals NHS Trust (1) · Ohio State University (1) · Radboud University Medical Center (1)
United States (15) · Canada (2) · Israel (2) · Pakistan (2) · Denmark (1) · Mexico (1) · Netherlands (1) · Poland (1) · Spain (1) · Switzerland (1) · Thailand (1) · United Kingdom (1)
Arturo Mendoza Valdes, MD (1) · Audrey N Schuetz, MD (1) · Ben Chew, MD (1) · Carolyn Botros, DO (1) · Cindy Amundsen, MD (1) · Daniel L Jackson, M.D. (1) · Daniel L Miller, MD MPH (1) · Deborah Lightner, MD (1) · Dina Bastawros, MD (1) · Erin S Lavelle, MD (1) · Hira Abbasi, BDS, FCPS II Trainee (1) · Jordan Gisseman, MD (1) · Katherine Amin, MD (1)
PMID 23611930, PMID 24463669, PMID 29710295, PMID 31503155, PMID 33620905, PMID 34824124, PMID 35349162, PMID 39836173, PMID 40279497, PMID 40722189, PMID 42026010