19 completed, 10 unknown, 6 terminated, 4 not yet recruiting. 45 Phase 3, 17 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 45 | Completed 19, Unknown 10, Terminated 6, Not yet recruiting 4, Recruiting 3, Withdrawn 3 |
| Phase 2 | 17 | Completed 7, Unknown 5, Not yet recruiting 2, Terminated 2, Withdrawn 1 |
Follow nitazoxanide: new trials by email Literature Review of nitazoxanide trials Research Report on nitazoxanide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nitazoxanide as Adjunct Therapy in Mild-to-Moderate Ulcerative Colitis Nitazoxanide (NTZ) - Ulcerative Colitis (UC) | Phase 2 / Phase 3 | Not yet recruiting | Tanta University | 44 | 2027-01-01 | 2026-09-15 |
| Nitazoxanide for Treatment of Cryptosporidium in Children Nitazoxanide, Placebo - Cryptosporidiosis | Phase 3 | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 480 | 2026-12-30 | 2026-09-28 |
| Efficacy and Safety of Nitazoxanide 600 Mg in the Outpatient Treatment of COVID-19 and Influenza Nitazoxanide 600Mg Oral Tablet / placebo oral tablet - Covid 19, Influenza | Phase 3 | Not yet recruiting | Azidus Brasil | 340 | 2025-02-01 | 2025-02-10 |
| Trial to Evaluate Nitazoxanide for Treatment of Mild COVID-19 in Subjects Not at High Risk of Severe Illness Nitazoxanide, Placebo, Vitamin Super-B Complex - COVID-19 | Phase 3 | Withdrawn | Romark Laboratories L.C. | 2024-08-01 | 2024-09-24 | |
| Trial to Evaluate Nitazoxanide for Treatment of Mild or Moderate COVID-19 in Subjects at High Risk of Severe Illness Nitazoxanide, Vitamin Super-B Complex, Placebo - COVID-19 | Phase 3 | Withdrawn | Romark Laboratories L.C. | 2024-08-01 | 2024-09-24 | |
| Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men Doxycyclin, Pentoxifylline, Nitazoxanide 500Mg Oral Tablet - Sexually Transmitted Diseases | Phase 2 / Phase 3 | Not yet recruiting | Tanta University | 100 | 2023-06-20 | 2023-06-12 |
| Nitazoxanide in Patients With Metastatic Colorectal Cancer Nitazoxanide - Metastatic Colorectal Cancer | Phase 3 | Unknown | Tanta University | 60 | 2023-03-01 | 2023-09-22 |
| Role of Nitazoxanide and Escitalopram in Patients With Rheumatoid Arthritis Placebo, Nitazoxanide 500Mg Oral Tablet, Escitalopram 10mg - Rheumatoid Arthritis | Phase 3 | Completed | Tanta University | 90 | 2022-12-02 | 2023-04-25 |
| Efficacy and Safety of Nitazoxanide 600 mg BID Versus Placebo for the Treatment of Hospitalized Patients With COVID-19 Nitazoxanide, Placebo - covid19 | Phase 3 | Unknown | Azidus Brasil | 380 | 2022-06-22 | 2022-10-31 |
| Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication Vonoprazan - Helicobacter Pylori Eradication | Phase 3 | Completed | Ain Shams University | 232 | 2022-01-01 | 2023-10-26 |
| Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection Nitazoxanide and Ciclésonide, Telmisartan 20Mg Oral Tablet, Paracetamol - Covid19, Covid19 Drug Treatment | Phase 2 / Phase 3 | Unknown | ANRS, Emerging Infectious Diseases | 600 | 2021-04-12 | 2023-01-31 |
| Nitazoxanide in Prevention of Secondary Spontaneous Peritonitis Nitazoxanide, Norfloxacin - Spontaneous Bacterial Peritonitis | Phase 3 | Unknown | Tanta University | 60 | 2021-03-01 | 2021-02-10 |
| Catalysing the Containment of COVID-19 Nitazoxanide, Placebo - COVID-19 | Phase 2 / Phase 3 | Terminated | University of Cape Town | 322 | 2020-08-27 | 2022-08-16 |
| Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Colds Due to Enterovirus/Rhinovirus Infection Nitazoxanide, Placebo, Vitamin Super B-Complex - Enterovirus, Rhinovirus | Phase 3 | Terminated | Romark Laboratories L.C. | 214 | 2020-08-19 | 2024-10-17 |
| Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19 Nitazoxanide, Placebo, Vitamin Super B-Complex - COVID-19 | Phase 3 | Completed | Romark Laboratories L.C. | 935 | 2020-08-13 | 2024-03-29 |
| Efficacy and Safety of Nitazoxanide 600 mg to Treat Mild Ambulatory COVID-19 Patients Nitazoxanide, Placebo - covid19 | Phase 2 / Phase 3 | Withdrawn | Azidus Brasil | 2020-07-01 | 2022-10-28 | |
| EAT-DUTA AndroCoV Trial Dutasteride 0.5 mg, Azithromycin, Nitazoxanide - Covid19 | Phase 2 / Phase 3 | Completed | Corpometria Institute | 138 | 2020-06-30 | 2021-01-28 |
| Efficacy and Safety Study of Nitazoxanide (NTX) in the Treatment of Patients With SARS-CoV-2 Virus Infection (COVID-19) Nitazoxanide, Placebo - COVID-19 | Phase 2 / Phase 3 | Unknown | Laboratorios Roemmers S.A.I.C.F. | 135 | 2020-06-26 | 2020-10-08 |
| Study of Nitazoxanide (NTZ) for Helicobacter Pylori in Children Nitazoxanide, Clarithromycin, Metronidazole - Helicobacter Pylori Infection | Phase 3 | Recruiting | Tanta University | 100 | 2020-06-01 | 2020-06-04 |
| Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- and Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers and Others at Increased Risk of SARS-CoV-2 Infection Nitazoxanide, Placebo, Vitamin Super B-Complex - COVID-19, Viral Respiratory Illnesses | Phase 3 | Completed | Romark Laboratories L.C. | 1407 | 2020-05-13 | 2024-06-26 |
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COVID-19 (14) · Influenza, Human (5) · Hepatitis C, Chronic (3) · Amebiasis (2) · Coronavirus Infections (2) · Cryptosporidiosis (2) · Enterovirus Infections (2) · Hepatic Encephalopathy (2) · Hepatitis C (2) · AIDS-Related Opportunistic Infections (1) · Adenoviridae Infections (1) · Arthritis, Rheumatoid (1) · Caliciviridae Infections (1) · Clostridium Infections (1) · Colitis, Ulcerative (1)
Romark Laboratories L.C. (18) · Tanta University (11) · Azidus Brasil (3) · Sherief Abd-Elsalam (2) · ANRS, Emerging Infectious Diseases (1) · Ain Shams University (1) · Cairo University (1) · Corpometria Institute (1) · Daniel M. Musher MD (1) · Haydom Lutheran Hospital (1) · Johns Hopkins Bloomberg School of Public Health (1) · Laboratorios Roemmers S.A.I.C.F. (1) · National Liver Institute, Egypt (1) · Telethon Kids Institute (1) · University of Cape Town (1)
Egypt (14) · United States (12) · Australia (4) · Puerto Rico (3) · Brazil (2) · Argentina (1) · Belgium (1) · Burkina Faso (1) · Canada (1) · Guinea (1) · New Zealand (1) · Peru (1) · South Africa (1) · Tanzania (1)
Jean-Francois Rossignol, M.D., Ph.D. (4) · Yehia El-Gohary, MD (3) · Samir M Kabil, MD (2) · Sherief Abd-Elsalam, lecturer (2) · Abeer Salamah, Lecturer (1) · Adam Bressler, MD (1) · Andy Goren, MD (1) · Asem Elfert, MD (1) · Asem Elfert, Prof (1) · Bradley Allen, MD (1) · Carlos G. Wambier, MD, Ph.D. (1) · Carol Kauffman, MD (1) · Daniel M Musher, M.D. (1) · Daniel Musher, MD (1) · David Johnson, MD (1)
PMID 16829296, PMID 19133801, PMID 22301075, PMID 23890273, PMID 24852376, PMID 28524341, PMID 29982218, PMID 34582462, PMID 35237748, PMID 36574985, PMID 36963502, PMID 39032770, PMID 41232946, PMID 42309304
U01AI167788 (1)