89 completed, 18 unknown, 5 terminated, 5 withdrawn. 33 Phase 2, 33 Phase 3, 27 Not applicable, 25 Phase 4, 18 Phase 1.
Follow NaCl: new trials by email Literature Review of NaCl trials Research Report on NaCl
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess How Well the Study Medicine IPN60340 Works in Combination With Azacitidine and Venetoclax, Compared to Placebo in Combination With Azacitidine and Venetoclax, in Participants With Newly Diagnosed Acute Myeloid Leukemia Who Cannot Receive Intensive Chemotherapy IPN60340 + azacitidine + venetoclax, Placebo + azacitidine + venetoclax - Acute Myeloid Leukaemia (AML), Acute Myeloid Leukaemia | Phase 2 / Phase 3 | Not yet recruiting | Ipsen | 540 | 2026-11-01 | 2026-09-10 |
| Preoperative BOTOX® Injection for Large Ventral Hernia Repair OnabotulinumtoxinA Injection, Saline (placebo) Injection, OnabotulinumtoxinA - Hernia Abdominal Wall, Botox Injection | Phase 4 | Recruiting | The Cleveland Clinic | 188 | 2025-11-03 | 2025-11-21 |
| Metabolic Effects of the Exercise-metabolite Lac-Phe N-lactoyl-phenylalanine, NaCl - Healthy Overweight/Obese | Not applicable | Completed | University of Aarhus | 23 | 2025-05-13 | 2026-03-27 |
| Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases Bevacizumab, Placebo, Prednisolone - Radionecrosis of Brain, Brain Metastases | Phase 3 | Recruiting | Institut Cancerologie de l'Ouest | 84 | 2025-04-29 | 2025-08-17 |
| The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain Sodium Lactate Solution, Saline infusion (placebo) - Healthy, Lactate Blood Increase | Not applicable | Not yet recruiting | University of Aarhus | 8 | 2025-02-01 | 2024-11-01 |
| Orthobiologic Treatment for Knee Osteoarthritis PRP injection, ADSTEM Inj. (Adult human mesenchymal stem cells), Injection - Osteoarthritis Knee | Phase 2 / Phase 3 | Enrolling by invitation | University Hospital of North Norway | 160 | 2024-09-23 | 2026-06-15 |
| Use of Presepsin as a Marker for Immunotherapy Administration in Pneumonia Anakinra Prefilled Syringe, Placebo - Community-acquired Pneumonia, Hospital-acquired Pneumonia | Phase 2 | Completed | Hellenic Institute for the Study of Sepsis | 60 | 2023-03-06 | 2024-07-31 |
| Nasal Allergen Challenge Test as a Method to Detect Clinical Reactivity Against Birch Pollen ITULAZAX 12 SQ-Bet, Placebo tablet, Nacl - Allergic Rhinitis Due to Pollen | Not applicable | Completed | Karolinska Institutet | 89 | 2023-02-01 | 2025-09-17 |
| A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in Patients With Pulmonary Hypertension After Cardiopulmonary Bypass Surgery PDNO, Sodium chloride (placebo) - Pulmonary Hypertension | Phase 2 | Unknown | Attgeno AB | 12 | 2022-10-23 | 2023-08-01 |
| Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity Sodium Phosphate, Sodium Chloride - Physical Inactivity, Phosphate Overload | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 124 | 2022-09-14 | 2026-02-17 |
| Safety, Tolerability and Pharmacokinetics of Intraarticular 4P004 Single Dose in Patient With KL 2-4 Osteoarthritic Knee 4P-004, Placebo - Knee Osteoarthritis | Phase 1 | Completed | 4Moving Biotech | 34 | 2022-08-09 | 2025-06-26 |
| Evaluation of Glucocorticoids Plus Rituximab in Patients With Newly-Diagnosed or Relapsing IgA Vasculitis Rituximab Injection, placebo - IgA Vasculitis | Phase 3 | Completed | Hopital Foch | 75 | 2022-03-11 | 2026-06-11 |
| Analgesic Effect of the QLB-3 for Patients Undergoing a Total Hip Surgery Ropivacaine injection, NACL - Total Hip Arthroplasty | Not applicable | Completed | Centre Hospitalier Universitaire de Nice | 60 | 2022-01-05 | 2026-03-24 |
| FITMI - First In Treating Male Infertility Denosumab, Sodium chloride - Infertility, Male | Phase 2 | Active not recruiting | Martin Blomberg Jensen | 180 | 2022-01-01 | 2024-11-15 |
| Zoledronate Early to Hip Fracture Patients - Safe and Effective? Zoledronic Acid 5Mg/Bag 100Ml Inj, sodium chloride - Hip Fractures, Osteoporosis | Phase 4 | Completed | Lene Bergendal Solberg | 228 | 2021-12-15 | 2026-08-12 |
| Zoledronic Acid as Adjuvant Therapy in Neovascular Age-related Macular Degeneration (Z-AMD) Zoledronic Acid 5 MG in 5 ML Injection, Placebos - Neovascular Age-related Macular Degeneration | Phase 2 | Completed | Oslo University Hospital | 40 | 2021-10-25 | 2024-04-05 |
| A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in COVID-19 Patients With Acute Pulmonary Hypertension Sodium chloride (placebo), PDNO - Pulmonary Hypertension, COVID-19 | Phase 1 / Phase 2 | Withdrawn | Attgeno AB | 2021-05-07 | 2023-08-01 | |
| The Role of Lactate in Lipolysis and Catabolism in Humans Na-lactate, Sodium chloride - Hyperlactatemia, Healthy | Not applicable | Completed | University of Aarhus | 8 | 2021-03-10 | 2022-01-24 |
| Efficacy and Safety Evaluation of Inhaleen Inhalation in Hospitalized COVID-19 Patients Carragelose, NaCl - Covid19 | Not applicable | Completed | Marinomed Biotech AG | 14 | 2021-03-08 | 2022-08-29 |
| Beta-blockade With Landiolol in Out-of-hospital Cardiac Arrest Landiolol, Sodium Chloride (NaCl) 0.9% - Cardiac Arrest | Phase 1 / Phase 2 | Unknown | Medical University of Vienna | 32 | 2021-03-03 | 2023-03-17 |
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Pain, Postoperative (6) · Pain (5) · COVID-19 (4) · Dengue (4) · Influenza, Human (4) · Severe Dengue (4) · Agnosia (3) · Hypertension, Pulmonary (3) · Obesity (3) · Osteoarthritis, Knee (3) · Postoperative Nausea and Vomiting (3) · Wounds and Injuries (3) · Anemia (2) · Corneal Neovascularization (2) · Coronary Artery Disease (2)
University of Aarhus (6) · Assistance Publique - Hôpitaux de Paris (5) · Sanofi Pasteur, a Sanofi Company (5) · Maastricht University Medical Center (4) · Medical University of Vienna (4) · Oslo University Hospital (4) · Attgeno AB (3) · Karolinska Institutet (3) · University of Witwatersrand, South Africa (3) · Copenhagen University Hospital, Rigshospitalet (2) · Ever Neuro Pharma GmbH (2) · Radboud University Medical Center (2) · Region Skane (2) · Reza Dana, MD (2) · 4Moving Biotech (1)
Denmark (21) · France (15) · United States (12) · Sweden (11) · Netherlands (8) · Norway (8) · Austria (7) · Belgium (3) · Germany (3) · South Africa (3) · Switzerland (3) · Australia (2) · Brazil (2) · China (2) · Colombia (2)
Cecilia Kemi, PhD (2) · Fred Troost, PhD (2) · Keith P Klugman, MD, PhD (2) · Reza Dana, MD, MPH, MSc (2) · Shabir A Madhi, MD, PhD (2) · Adam Linder, MD (1) · Adriana Weinberg (1) · Adriana Weinberg, MD (1) · Adriana Weinberg, PhD (1) · Ahmed ELbadawy, MD (1) · Alfred Kocher, MD (1) · Anders Fomsgaard, DMSc (1) · Anders Perner, Professor (1)
PMID 25184864, PMID 28369198, PMID 29253090, PMID 38743692, PMID 10195546, PMID 10211042, PMID 10364865, PMID 10389815, PMID 10460554, PMID 10469712, PMID 10472223, PMID 10475291, PMID 10792142, PMID 10819855, PMID 10866915, PMID 11495870, PMID 11878707, PMID 12031757, PMID 12088814, PMID 12095019, PMID 12401245, PMID 12738502, PMID 14566537, PMID 15044599, PMID 15064269, PMID 15150204, PMID 15470169, PMID 15471636, PMID 15576519, PMID 15625255, PMID 15678734, PMID 15781547, PMID 15983143, PMID 16905766, PMID 17006084, PMID 17224148, PMID 1730311, PMID 17481622, PMID 18958771, PMID 19108937, PMID 19254307, PMID 19641980, PMID 20409331, PMID 20638340, PMID 21427372, PMID 21791296, PMID 22102646, PMID 22282884, PMID 22464086, PMID 22751595
2014 (4), 2015 (3), 2008 (2), 2009 (2), 2016 (2), 2018 (2), 2017 (1)