7 completed, 6 unknown, 2 active not recruiting, 2 not yet recruiting. 5 Not applicable, 5 Phase 2, 5 Phase 3, 5 Phase 4, 2 Early Phase 1.
Follow N Acetyl Cysteine: new trials by email Literature Review of N Acetyl Cysteine trials Research Report on N Acetyl Cysteine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver Failure N Acetyl Cysteine, Standard supportive care - Acute Liver Failure | Not applicable | Recruiting | King Edward Medical University | 62 | 2026-07-16 | 2026-08-19 |
| Comparing N-Acetylcysteine (NAC) Versus Alpha-Lipoic Acid (ALA) as Adjuncts for Postoperative Pain Management After Laparoscopic Appendectomy N Acetyl Cysteine, Alpha-Lipoic Acid (ALA), Placebo - Laparoscopic Appendectomy, Pain Management | Not applicable | Not yet recruiting | Ain Shams University | 180 | 2025-12-28 | 2026-01-22 |
| Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z) - Drug Induced Liver Injury, Tuberculosis (TB) | Phase 1 | Not yet recruiting | Liaquat National Hospital & Medical College | 410 | 2025-07-01 | 2025-07-10 |
| Evaluation of the Role of N Acetyl Cysteine and Vitamin D in Improving Outcomes After Corrosive Ingestion N Acetyl Cysteine, Vitamin D (Cholecalciferol ), control group - Corrosive Injury | Phase 3 | Active not recruiting | Ain Shams University | 80 | 2024-10-01 | 2025-11-17 |
| N-Acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement N acetyl cysteine, normal saline - Oxidative Stress, Liver Dysfunction | Phase 4 | Completed | Kasr El Aini Hospital | 54 | 2024-06-30 | 2025-08-29 |
| Gene-guided N-acetyl Cysteine for Prophylaxis of Anti-tuberculous Drug- Induced Hepatitis N acetyl cysteine - Tuberculosis (TB), Isoniazid Toxicity | Phase 4 | Unknown | Mahidol University | 116 | 2024-03-12 | 2024-07-03 |
| Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients N acetyl cysteine - Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity | Phase 2 | Unknown | Ain Shams University | 60 | 2024-02-01 | 2024-03-07 |
| Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients N acetyl cysteine, Placebo - Linezolid, Antioxidant | Phase 4 | Completed | Helwan University | 250 | 2023-08-01 | 2025-07-14 |
| Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Trial N acetyl cysteine, Placebo - Autism Spectrum Disorder | Phase 2 / Phase 3 | Recruiting | Stanford University | 144 | 2023-04-26 | 2026-05-15 |
| Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste N Acetyl Cysteine, Calcium Hydroxide (Ca(OH)2), Double Antibiotic Paste - Chronic Apical Periodontitis | Not applicable | Completed | Ataturk University | 45 | 2022-09-10 | 2026-01-15 |
| Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial N acetyl cysteine - Tuberculosis, Drug Induced Liver Injury | Phase 2 / Phase 3 | Unknown | Mahidol University | 82 | 2022-09-09 | 2023-02-22 |
| The Role of N-acetylcysteine as a Novel Adjuvant Treatment in Acute Organophosphorus Pesticide Poisoning n acetyl cysteine, standard treatment - Acute Organophosphorus Poisoned Patients | Early Phase 1 | Completed | Ain Shams University | 40 | 2022-01-01 | 2023-07-03 |
| Intravenous NAC Use in ACLF Patients N acetyl cysteine, Placebo of N acetyl cysteine - Acute on Chronic Liver Failure(ACLF) | Not applicable | Unknown | Aga Khan University | 100 | 2021-11-01 | 2021-10-22 |
| N-acetyl Cysteine for the Prevention of Oral Mucositis After Autologous Hematopoietic Cell Transplantation. N acetyl cysteine - Mucositis, Transplant-Related Disorder | Phase 3 | Unknown | moshe yeshurun | 116 | 2021-04-01 | 2021-02-16 |
| FDOPA PET and Nutritional Support in Parkinson's Disease N acetyl cysteine, [F-18] Fluorodopa Positron Emission Tomography - Parkinson Disease, Idiopathic Parkinson Disease | Phase 2 | Active not recruiting | Thomas Jefferson University | 50 | 2020-04-30 | 2025-07-29 |
| NAC for Head Trauma-induced Anosmia N Acetyl Cysteine, Placebo oral capsule - Anosmia, Head Trauma | Phase 3 | Terminated | University of Miami | 7 | 2018-10-12 | 2021-02-04 |
| N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization N acetyl cysteine - Endodontic Disease | Early Phase 1 | Terminated | University of California, Los Angeles | 7 | 2018-06-15 | 2026-01-21 |
| Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement N Acetyl Cysteine, Placebos - Surgery--Complications, Cardiac Valve Disease | Phase 4 | Unknown | University of Sao Paulo General Hospital | 154 | 2018-03-15 | 2018-03-05 |
| Use of NAC in Alleviation of Hangover Symptoms N Acetyl Cysteine, placebo - Hangover Symptoms, NAC | Not applicable | Completed | St. Luke's Hospital and Health Network, Pennsylvania | 62 | 2015-08-01 | 2018-05-30 |
| N Acetyl Cysteine for Cystinosis Patients N acetyl cysteine - Renal Disease, Cystinosis | Phase 4 | Completed | University of Sao Paulo | 23 | 2011-03-01 | 2012-06-20 |
Showing 20 of 21. Sign in to see all of them.
Tuberculosis (3) · Chemical and Drug Induced Liver Injury (2) · Pain, Postoperative (2) · Acute Kidney Injury (1) · Acute-On-Chronic Liver Failure (1) · Agnosia (1) · Anosmia (1) · Autism Spectrum Disorder (1) · Central Nervous System Diseases (1) · Craniocerebral Trauma (1) · Critical Illness (1) · Cystinosis (1) · Dental Pulp Diseases (1) · Gambling (1) · Heart Valve Diseases (1)
Ain Shams University (4) · Mahidol University (2) · Aga Khan University (1) · Ataturk University (1) · Helwan University (1) · Kasr El Aini Hospital (1) · King Edward Medical University (1) · Liaquat National Hospital & Medical College (1) · St. Luke's Hospital and Health Network, Pennsylvania (1) · Stanford University (1) · Thomas Jefferson University (1) · University of California, Los Angeles (1) · University of Chicago (1) · University of Miami (1) · University of Sao Paulo (1)
United States (6) · Egypt (5) · Pakistan (2) · Thailand (2) · Brazil (1) · Turkey (Türkiye) (1)
Ariba Sultan (1) · Ceren Yeniay (1) · Daniel A Monti, MD, MBA (1) · David C Han, DDS, MS (1) · Eglal H Elawady, Professor of toxicology (1) · Holly A Stankewicz, D.O. (1) · John Hegarty, PhD (1) · Jon E Grant, MD, JD, MPH (1) · Marc N Potenza, MD, PhD (1) · Maria Helena Vaisbich, Doctor (1) · Mohamed Abdeltawab, Pharm D (1) · Roy Casiano, MD (1) · Sarah S Mohammed (1) · Somia Iqtadar, FCPS (1)
PMID 10836917, PMID 14506405, PMID 15706734, PMID 16363316, PMID 16373736, PMID 23586456, PMID 24345329, PMID 26400476, PMID 27309537, PMID 36130734, PMID 41577060, PMID 9783643
1RC1DA028279-01 (1), R00HD101702 (1)