24 completed, 7 terminated, 4 unknown, 1 approved for marketing. 18 Phase 1, 16 Phase 2, 3 Not applicable, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 16, Terminated 2 |
| Phase 2 | 16 | Completed 8, Terminated 6, Unknown 2 |
| Not applicable | 3 | Unknown 2, Completed 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow motexafin gadolinium: new trials by email Literature Review of motexafin gadolinium trials Research Report on motexafin gadolinium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Studying Repeated DCE-MRI and DWI in Patients Diagnosed With Prostate Cancer motexafin gadolinium - Prostate Cancer | Not applicable | Unknown | American College of Radiology Imaging Network | 30 | 2012-08-27 | 2021-10-18 |
| Contrast-Enhanced CT and MRI in Diagnosing and Staging Liver Cancer Using UNOS Policy iodinated contrast dye, motexafin gadolinium, Eovist-enhanced MRI - Liver Cancer | Not applicable | Unknown | American College of Radiology Imaging Network | 440 | 2010-12-01 | 2023-07-07 |
| Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL Rituximab, Cytarabine, Methotrexate - Brain and Central Nervous System Tumors, Lymphoma | Early Phase 1 | Withdrawn | Northwestern University | 2008-11-01 | 2012-05-18 | |
| Sunitinib Before and After Surgery in Treating Patients With Stage IV Kidney Cancer motexafin gadolinium, sunitinib malate, comparative genomic hybridization - Kidney Cancer | Phase 2 | Unknown | Abramson Cancer Center at Penn Medicine | 20 | 2008-06-01 | 2014-01-10 |
| Temozolomide and Radiation Therapy in Treating Young Patients With Pontine Glioma motexafin gadolinium, temozolomide, adjuvant therapy - Brain and Central Nervous System Tumors | Phase 2 | Unknown | Children's Cancer and Leukaemia Group | 43 | 2008-01-01 | 2013-08-12 |
| Motexafin Gadolinium and Radiation Therapy in Treating Young Patients With Pontine Glioma motexafin gadolinium, 3-dimensional conformal radiation therapy - Untreated Childhood Brain Stem Glioma | Phase 2 | Completed | National Cancer Institute (NCI) | 64 | 2007-06-01 | 2018-01-04 |
| Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer Motexafin gadolinium and pemetrexed - Non-Small Cell Lung Carcinoma | Phase 2 | Terminated | Pharmacyclics LLC. | 74 | 2006-06-01 | 2013-10-31 |
| Study of the Effect on Non-small Cell Lung Cancer of the Investigational Drug Motexafin Gadolinium When Used in Combination With Docetaxel (Taxotere) Motexafin Gadolinium - Lung Cancer | Phase 2 | Terminated | Pharmacyclics LLC. | 50 | 2006-05-01 | 2014-07-24 |
| Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma 3-Dimensional Conformal Radiation Therapy, Motexafin Gadolinium, Temozolomide - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 118 | 2006-02-09 | 2018-03-05 |
| Study of Weekly Motexafin Gadolinium (MGd) for Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma motexafin gadolinium - Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | Phase 1 / Phase 2 | Completed | Pharmacyclics LLC. | 35 | 2005-11-01 | 2008-09-11 |
| Study of Motexafin Gadolinium (MGd) for Second Line Treatment of Non-Small-Cell Lung Cancer Motexafin Gadolinium - Adenocarcinoma, Non-Small-Cell Lung Carcinoma | Phase 2 | Completed | Pharmacyclics LLC. | 108 | 2005-09-01 | 2008-08-20 |
| A Study of Motexafin Gadolinium (MGd) in Combination With Docetaxel and Cisplatin for Treatment of Non-Small Cell Lung Cancer (NSCLC) Motexafin Gadolinium Injection - Non-Small-Cell Lung Carcinoma, Carcinoma, Bronchogenic | Phase 1 | Completed | Pharmacyclics LLC. | 36 | 2004-11-01 | 2009-04-03 |
| Study of Motexafin Gadolinium (MGd) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Motexafin Gadolinium - Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | Phase 2 | Terminated | Pharmacyclics LLC. | 27 | 2004-10-01 | 2014-05-23 |
| Phase I/II Trial of Redox Regulation in Patients With Relapsed or Refractory CD20+ NHL Rituxan, motexafin gadolinium, 111Indium-Zevalin and 90Yttrium-Zevalin - Non-Hodgkin's Lymphoma (NHL) | Phase 1 / Phase 2 | Terminated | Northwestern University | 30 | 2003-10-28 | 2019-08-14 |
| Gadolinium Texaphyrin Plus Radiation Therapy in Treating Patients With Supratentorial Glioblastoma Multiforme motexafin gadolinium, radiation therapy - Brain and Central Nervous System Tumors | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 6 | 2002-04-10 | 2018-06-27 |
| Motexafin Gadolinium in Treating Patients With Glioblastoma Multiforme Who Are Undergoing Radiation Therapy to the Brain motexafin gadolinium, radiation therapy - Brain and Central Nervous System Tumors | Phase 1 | Completed | National Cancer Institute (NCI) | 2002-04-01 | 2009-02-09 | |
| Motexafin Gadolinium and Doxorubicin in Treating Patients With Advanced Cancer doxorubicin hydrochloride, motexafin gadolinium - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 1 | Completed | University of Wisconsin, Madison | 2002-02-01 | 2019-12-17 | |
| Motexafin Gadolinium Plus Radiation Therapy to the Brain in Treating Patients With Newly Diagnosed Glioblastoma Multiforme motexafin gadolinium, radiation therapy - Brain and Central Nervous System Tumors | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 2001-04-01 | 2013-06-18 | |
| Radiation Therapy Plus Gadolinium Texaphyrin in Treating Patients With Cancer of the Pancreas That Cannot Be Removed by Surgery motexafin gadolinium, radiation therapy - Pancreatic Cancer | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 45 | 2000-04-01 | 2012-11-14 |
| Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Stage IIIA Non-small Cell Lung Cancer paclitaxel, carboplatin, motexafin gadolinium - Stage IIIA Non-small Cell Lung Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 2000-01-01 | 2013-06-04 |
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Glioblastoma (9) · Carcinoma, Non-Small-Cell Lung (8) · Lung Neoplasms (8) · Central Nervous System Neoplasms (7) · Gliosarcoma (7) · Breast Neoplasms (5) · Lymphoma (5) · Prostatic Neoplasms (5) · Kidney Neoplasms (4) · Leukemia (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Brain Neoplasms (3) · Head and Neck Neoplasms (3) · Lymphoma, Non-Hodgkin (3) · Neoplasm Metastasis (3)
Pharmacyclics LLC. (16) · National Cancer Institute (NCI) (6) · Abramson Cancer Center at Penn Medicine (2) · American College of Radiology Imaging Network (2) · Jonsson Comprehensive Cancer Center (2) · Northwestern University (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Children's Cancer and Leukaemia Group (1) · Memorial Sloan Kettering Cancer Center (1) · Stanford University (1) · University of Pittsburgh (1) · University of Wisconsin, Madison (1)
United States (34) · Canada (5) · Australia (1) · Austria (1) · Belgium (1) · France (1) · Germany (1) · Ireland (1) · Netherlands (1) · Russia (1) · Serbia (1) · United Kingdom (1)
Andrew M. Evens, DO, MS (2) · James L. Pearlman, MD (2) · John Grecula (2) · Andrei H Iagaru (1) · Andrew Evens, D.O. (1) · Andrew Evens, DO (1) · Brad Kahl, MD (1) · Christoph Wald, MD, PhD (1) · David Brachman (1) · Gregory Rubino, MD (1) · Gurkamal Chatta, MD (1) · Jeffrey J. Raizer, MD (1) · Josh Yamada, MD (1) · Judith M. Ford, MD, PhD (1) · Keith T. Flaherty, MD (1)
PMID 15800894, PMID 16180217, PMID 17560737, PMID 25041904, PMID 25832688
P30CA006973 (2), U01CA076576 (2), U01CA079778 (2), U01CA080098 (2), P30CA014520 (1), U01CA097452 (1), U10CA021661 (1), U10CA098543 (1)