57 completed, 18 unknown, 11 terminated, 5 recruiting. 29 Not applicable, 22 Phase 2, 22 Phase 3, 19 Phase 4, 8 Phase 1.
Follow Morphine Sulfate: new trials by email Literature Review of Morphine Sulfate trials Research Report on Morphine Sulfate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department Parecoxib, Morphine - Sickle-Cell Disease with Crisis | Phase 3 | Not yet recruiting | Oman Medical Speciality Board | 226 | 2026-05-01 | 2025-03-20 |
| Modified Thoracolumbar Interfascial Plane Block vs Retrolaminar Block for Pain in Lumbar Spine Surgeries Morphine, Bupivacaine, Dexamethasone - Postoperative Pain After Spinal Surgery | Not applicable | Recruiting | Zagazig University | 42 | 2025-10-01 | 2026-10-20 |
| Comparison of Pruritus Incidence After Intrathecal Morphine 0.1 vs 0.2 mg in Cesarean Section Morphine Sulfate - Pruritus Caused by Drug | Phase 4 | Recruiting | Khon Kaen University | 69 | 2025-06-01 | 2025-07-08 |
| Effectiveness of Ultrasound-Guided Erector Spinae Plane Block for Postoperative Pain Control in Open Knee Surgeries erector spinea plane block, Morphine Sulfate - Knee Injuries | Not applicable | Enrolling by invitation | Cairo University | 40 | 2025-03-01 | 2025-02-17 |
| Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain Ketorolac Tromethamine, Morphine Sulfate, normal saline - Acute Pain, Abdomen, Acute | Phase 3 | Recruiting | University of Calgary | 495 | 2024-05-27 | 2024-06-24 |
| Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery Morphine Sulfate, Placebo - Pain, Postoperative | Phase 4 | Recruiting | Northwestern University | 90 | 2023-09-29 | 2026-06-09 |
| Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds Morphine Sulfate, Lidocaine Hcl 2% Jelly - Wounds and Injuries, Cancer Pain | Phase 2 | Unknown | Instituto Nacional de Cancer, Brazil | 106 | 2023-09-12 | 2023-09-28 |
| Comparison of Local Anesthetic Dose in Ipack Block Performed in Knee Arthroplasty Operations Bupivacaine, Morphine Sulfate - Analgesia, Pain, Postoperative | Not applicable | Completed | Istanbul University | 112 | 2023-08-01 | 2024-02-13 |
| Comparison of Paravertebral Block and Subcostal Transversus Abdominis Plane Block in Laparoscopic Nephrectomy Bupivacain, Morphine - Analgesia, Anesthesia | Not applicable | Completed | Istanbul University | 91 | 2023-02-15 | 2024-03-12 |
| Intrathecal Morphine 75 mcg Versus 100 mcg for Post-Cesarean Analgesia: A Randomized Double-blind Trial Intrathecal Morphine - Postoperative Pain, Cesarean Section | Phase 4 | Completed | Hospital Universitario de Caracas | 240 | 2023-01-07 | 2026-04-08 |
| Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy Ketorolac Tromethamine, Morphine Sulfate, Intravenous Placebo for NTM-001 - Pain, Postoperative | Phase 3 | Suspended | Neumentum, Inc. | 341 | 2022-12-14 | 2026-04-23 |
| Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) Dexmedetomidine Hydrochloride, Morphine Sulfate - Hypoxic-Ischemic Encephalopathy, Pain | Phase 2 | Completed | University of Utah | 50 | 2022-06-20 | 2026-03-06 |
| Comparison Between Pericapsular Nerve Group Block (PENG) and Morphine Infusion Pericapsular nerve group block, Morphine Sulfate - Analgesia, Femur Fracture | Not applicable | Completed | Suez Canal University | 36 | 2022-04-01 | 2022-09-13 |
| Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen Ibuprofen 800 mg, Morphine Sulfate, Ibuprofen 400 mg plus Acetaminophen 1000 mg - Multiple Trauma, Acute Pain Due to Trauma | Phase 3 | Completed | Isfahan University of Medical Sciences | 150 | 2022-03-15 | 2023-09-07 |
| Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy Levomethadone HCl, Methadone, Morphine Sulfate - Opioid Use Disorder, Moderate | Phase 1 | Withdrawn | Lyndra Inc. | 2022-02-28 | 2023-01-19 | |
| Intrathecal Morphine for Cesarean Delivery Morphine Sulfate - Postoperative Pain | Phase 4 | Completed | Beth Israel Deaconess Medical Center | 72 | 2021-11-15 | 2025-11-13 |
| Evaluation of the Interactions of Cannabidiol (CBD) With Morphine Morphine Sulfate - Opioid Use Disorder | Phase 1 | Unknown | National Institute on Drug Abuse (NIDA) | 60 | 2021-11-04 | 2024-03-27 |
| Postoperative Pain Control by Use of Many Drugs in Small Doses Intrathecally Morphine Sulfate, Bupivacaine, dexamethasone, morphine, midazolam - Post Operative Pain | Phase 2 | Unknown | Sohag University | 60 | 2021-05-23 | 2022-01-28 |
| TAP Block With Intrathecal Fentanyl vs. Intrathecal Morphine in Cesarean Delivery fentanyl, morphine, Transversus abdominis plane block - Cesarean Section | Not applicable | Completed | Seoul National University Hospital | 80 | 2021-04-12 | 2022-02-24 |
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Pain (27) · Pain, Postoperative (24) · Agnosia (11) · Neonatal Abstinence Syndrome (6) · Anemia, Sickle Cell (3) · Dyspnea (3) · Lymphoma, Follicular (3) · Abdominal Pain (2) · Acute Pain (2) · Blast Crisis (2) · Breast Neoplasms (2) · Burkitt Lymphoma (2) · Cancer Pain (2) · Chemically-Induced Disorders (2) · Emergencies (2)
Assiut University (4) · Roxane Laboratories (4) · QRxPharma Inc. (3) · Bursa Yuksek Ihtisas Training and Research Hospital (2) · Flinders University (2) · Henrietta Bada (2) · Inonu University (2) · Istanbul University (2) · Ranbaxy Inc. (2) · Seoul National University Hospital (2) · Actavis Inc. (1) · Akela Pharma, Inc. (1) · Alameda Health System (1) · Albert Einstein College of Medicine (1) · Alexandria University (1)
United States (43) · Egypt (12) · Canada (6) · Turkey (Türkiye) (6) · France (4) · South Korea (3) · Poland (2) · Saudi Arabia (2) · United Kingdom (2) · Australia (1) · Brazil (1) · Germany (1) · Iran (1) · Ireland (1) · New Zealand (1)
Patricia T. Richards, MD, Ph.D. (3) · David C Currow, MD, PhD (2) · Fredrick A Bieberdorf, M.D. (2) · Ahmed F Mahmoud Hussein, MS.c (1) · Alla Kushnir, MD (1) · Andrew Bishara, MD (1) · Barry Lester, PhD (1) · Carl Talmo, MD (1) · Chi Hornik, PharmD (1) · Costantine Albany, M.D. (1) · Dante Landucci, M.D. (1)
PMID 34231914, PMID 23360885, PMID 24106351, PMID 10150800, PMID 10690153, PMID 11050519, PMID 11402405, PMID 11929206, PMID 11940739, PMID 12006425, PMID 12761013, PMID 12770663, PMID 12961065, PMID 14117648, PMID 1421731, PMID 14999112, PMID 15471273, PMID 15566593, PMID 15983470, PMID 16870842, PMID 17110415, PMID 17395760, PMID 17397698, PMID 17507545, PMID 18073550, PMID 18201934, PMID 18206527, PMID 18344573, PMID 18706531, PMID 19135997, PMID 19209273, PMID 19214642, PMID 1934205, PMID 19462494, PMID 19535182, PMID 19663845, PMID 20075059, PMID 20078243, PMID 21037472, PMID 21115606, PMID 21519308, PMID 21572329, PMID 21576107, PMID 2164935, PMID 21699998, PMID 21956081, PMID 22522612, PMID 23575612, PMID 24157897, PMID 24781562
2014 (1), 2019 (1), 4UH3DA050310-02 (1), P30CA006973 (1), R01DA043519 (1), R01DK079974 (1), U24HL137907 (1)