25 completed. 25 Phase 2, 3 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 25 | Completed 25 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 3 | Completed 3 |
Follow Mitomycin c: new trials by email Literature Review of Mitomycin c trials Research Report on Mitomycin c
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intralesional Injection of Mitomycin C Following Visual Internal Urethrotomy for Recurrent Urethral Stricture Mitomycin c - Urethral Stricture | Phase 2 / Phase 3 | Completed | Ain Shams University | 50 | 2022-01-01 | 2024-01-30 |
| Trial of Mitomycin C During Nephroureterectomy for Urothelial Carcinoma Mitomycin c - Urothelial Carcinoma | Phase 2 | Completed | University of Florida | 29 | 2018-12-05 | 2024-11-05 |
| Avelumab in Combination With Fluorouracil and Mitomycin or Cisplatin and Radiation Therapy in Treating Participants With Muscle-Invasive Bladder Cancer Avelumab, Cisplatin, Fluorouracil - Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall, Stage II Bladder Cancer AJCC v8 | Phase 2 | Completed | Mayo Clinic | 2 | 2018-09-19 | 2023-01-06 |
| Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology Surgery, Cisplatin, Mitomycin C - Gastric Adenocarcinoma, Esophagogastric Junction | Phase 2 | Completed | National Cancer Institute (NCI) | 27 | 2017-06-05 | 2025-02-19 |
| Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Mitomycin - Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 24 | 2016-09-01 | 2024-09-19 |
| Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN) Methotrexate, Vinblastine, Doxorubicin - Urothelial Carcinoma of the Bladder | Phase 2 | Completed | Fox Chase Cancer Center | 78 | 2016-02-24 | 2026-05-22 |
| Safety of Pre-TURBT Intravesical Instillation of Escalating Doses of TC-3 Gel and MMC in NMIBC Patients 120 mg MMC in 90ml gel, 140 mg MMC in 90ml gel, 160 mg MMC in 90ml gel - Bladder Cancer, Neoplasms | Phase 2 | Completed | UroGen Pharma Ltd. | 14 | 2014-12-01 | 2017-06-16 |
| Phacotrabeculectomy With Collagen Matrix Implant (Ologen®) Versus Mitomycin C Ologen, Phacotrabeculectomy, Mitomycin C - Glaucoma, Cataract | Phase 2 | Completed | Medical University of Lublin | 53 | 2014-06-02 | 2018-04-25 |
| Laparoscopic Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) for Metastatic Gastric Cancer Mitomycin C, Cisplatin, Sodium Thiosulfate - Gastrointestinal Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 21 | 2014-05-08 | 2021-06-15 |
| Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma Standard Guarded Trabeculectomy, Mitomycin C, Bevacizumab - Glaucoma | Phase 2 / Phase 3 | Completed | Athens Vision Eye Institute | 40 | 2014-01-01 | 2016-09-15 |
| Study of Individualized Therapies Selection for Patients With Metastatic Colorectal Carcinoma According to the Therapeutic Arm A chemotherapy, arm B chemotherapy - Adenocarcinoma of Colon, Adenocarcinoma of Rectum | Phase 2 | Completed | Centro Nacional de Investigaciones Oncologicas CARLOS III | 29 | 2012-11-01 | 2015-10-09 |
| HIPEC for Peritoneal Carcinomatosis HIPEC, Mitomycin C - Peritoneal Carcinomatosis, Colorectal Cancer | Phase 2 | Completed | Albert Einstein College of Medicine | 51 | 2011-11-01 | 2024-10-24 |
| Results of Adjunctive Intraoperative Bevacizumab Injection on Trabeculectomy Outcome Bevacizumab, Mitomycin C - Glaucoma | Phase 2 / Phase 3 | Completed | Prince of Songkla University | 39 | 2010-12-01 | 2014-01-31 |
| Safety Study of Avastin Used as Adjunctive Therapy in Pterygium Surgery Bevacizumab, Mitomycin C - Pterygium | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 51 | 2010-10-01 | 2016-10-21 |
| Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix mitomycin C, oxaliplatin, therapeutic conventional surgery - Carcinoma of the Appendix, Primary Peritoneal Cavity Cancer | Phase 2 | Completed | Wake Forest University Health Sciences | 136 | 2009-05-01 | 2018-07-03 |
| Use of Ranibizumab With Mitomycin C During Trabeculectomy Ranibizumab, Ranibizumab and MMC, MMC - Glaucoma | Phase 1 / Phase 2 | Completed | University of Colorado, Denver | 30 | 2008-04-01 | 2016-10-13 |
| Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae Mitomycin C, Teflon nasal septal splint - Nasal Synechiae, Adhesions of Nasal Cavity | Phase 2 | Completed | Karnataka Institute of Medical Sciences | 60 | 2007-10-01 | 2011-07-08 |
| Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer fluorouracil, mitomycin C, Intensity-modulated radiation therapy - Anal Cancer | Phase 2 | Completed | Radiation Therapy Oncology Group | 63 | 2006-12-01 | 2019-02-27 |
| Safety Study of Recombinant Human Hyaluronidase (Chemophase) in Combination With Mitomycin in Participants With Superficial Bladder Cancer Mitomycin C, Chemophase - Bladder Cancer | Phase 1 / Phase 2 | Completed | Halozyme Therapeutics | 27 | 2006-03-30 | 2021-10-29 |
| A Randomized Study Comparing Single Agent Gemcitabine Intravesical Therapy Versus Mitomycin C in Patients With Intermediate Risk Superficial Bladder Cancer Gemcitabine, mitomycin C - Superficial Bladder Cancer | Phase 2 | Completed | Eli Lilly and Company | 90 | 2003-12-01 | 2007-05-17 |
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Glaucoma (4) · Urinary Bladder Neoplasms (4) · Neoplasm Metastasis (3) · Non-Muscle Invasive Bladder Neoplasms (3) · Stomach Neoplasms (3) · Appendiceal Neoplasms (2) · Gastrointestinal Neoplasms (2) · Peritoneal Neoplasms (2) · Adenocarcinoma (1) · Anal Canal Carcinoma (1) · Anus Neoplasms (1) · Carcinoma, Transitional Cell (1) · Cataract (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1)
M.D. Anderson Cancer Center (2) · Mayo Clinic (2) · Ain Shams University (1) · Albert Einstein College of Medicine (1) · Athens Vision Eye Institute (1) · Centro Nacional de Investigaciones Oncologicas CARLOS III (1) · Eli Lilly and Company (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fox Chase Cancer Center (1) · Halozyme Therapeutics (1) · Karnataka Institute of Medical Sciences (1) · Medical University of Lublin (1) · National Cancer Institute (NCI) (1) · Ohio State University Comprehensive Cancer Center (1) · Prince of Songkla University (1)
United States (14) · Israel (2) · Belgium (1) · Canada (1) · Egypt (1) · India (1) · Italy (1) · Netherlands (1) · Portugal (1) · Spain (1) · Thailand (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Aldo V. Bono, MD (1) · Brian D Badgwell (1) · Brian D. Badgwell, MD (1) · Carsten Bokemeyer, MD (1) · Edward Levine (1) · Gerassimos Kopsinis, M.D., Ph.D. (1) · Ifat Klein, PhD (1) · Jeremy L Davis, M.D. (1) · Joerg T Hartmann, MD (1) · John McAuliffe, M.D. (1) · Lisa A. Kachnic, MD (1) · Malik Y. Kahook, MD (1) · Miguel Villalona, MD (1)
PMID 17470859, PMID 20354452, PMID 20570237, PMID 21156335, PMID 28643069, PMID 32556731, PMID 33660142, PMID 34125951, PMID 39680823, PMID 41074972
P30CA015083 (1), U10CA032102 (1)