22 completed, 6 terminated, 2 active not recruiting, 1 recruiting. 15 Phase 3, 9 Phase 2, 6 Phase 4, 3 Phase 1, 1 Not applicable.
Follow Methylphenidate Hydrochloride: new trials by email Literature Review of Methylphenidate Hydrochloride trials Research Report on Methylphenidate Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methylphenidate in KBG Syndrome: N-of-1 Series Methylphenidate Hydrochloride, Placebo - Kbg Syndrome, ADHD - Combined Type | Phase 4 | Recruiting | Radboud University Medical Center | 15 | 2024-11-13 | 2026-08-11 |
| Methylphenidate in Childhood Apraxia of Speech Methylphenidate Hydrochloride, Placebo - Childhood Apraxia of Speech | Phase 2 | Completed | Murdoch Childrens Research Institute | 18 | 2022-03-14 | 2026-10-13 |
| FASST - Fetal Alcohol Spectrum Stimulant Trial Methylphenidate Hydrochloride, Placebo, Methylphenidate hydrochloride - Fetal Alcohol Spectrum Disorders | Phase 4 | Unknown | Monash Medical Centre | 20 | 2022-02-14 | 2022-12-13 |
| Real World Evidence of the Efficacy and Safety of FOQUEST Methylphenidate Hydrochloride, Lisdexamfetamine Dimesylate - Attention Deficit-Hyperactivity Disorder | Phase 4 | Completed | Purdue Pharma, Canada | 257 | 2019-09-19 | 2021-09-16 |
| Investigating the Impact of Methylphenidate on Neural Response in Disruptive Behavioral Disorder Methylphenidate Hydrochloride - Conduct Disorder, Attention Defict Hyperactivity Disorder | Phase 1 / Phase 2 | Withdrawn | National Institute of Mental Health (NIMH) | 2014-09-04 | 2019-12-03 | |
| Cognitive Behavioral Therapy and Multimodal Therapy in Treating Sleep Disturbance in Patients With Cancer Counseling, Methylphenidate Hydrochloride, Phototherapy - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 68 | 2014-01-15 | 2026-05-22 |
| The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects methylphenidate hydrochloride, Sugar pill (placebo) - Pharmacological Action (PA) | Phase 2 | Completed | Rambam Health Care Campus | 41 | 2013-07-01 | 2017-09-12 |
| Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder Lisdexamfetamine dimesylate, Methylphenidate Hydrochloride, Placebo - Attention-deficit/Hyperactivity Disorder | Phase 4 | Completed | Shire | 464 | 2012-04-17 | 2021-06-08 |
| Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder Lisdexamfetamine dimesylate, Methylphenidate Hydrochloride, Placebo - Attention-deficit/Hyperactivity Disorder | Phase 4 | Completed | Shire | 549 | 2012-04-03 | 2021-06-10 |
| Multimodal Therapy for the Treatment of Fatigue in Patients With Prostate Cancer Receiving Radiotherapy With Androgen Deprivation Therapy Placebo, Methylphenidate, Counseling Sessions - Prostate Cancer | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 175 | 2012-02-08 | 2026-09-03 |
| A Study to Examine the Progression of Attention-Deficit Hyperactivity Disorder (ADHD) Drug Treatment and to Analyze Associated Factors Methylphenidate hydrochloride, Atomoxetine - Attention-deficit Hyperactivity Disorder | Completed | Janssen Korea, Ltd., Korea | 289 | 2012-02-01 | 2015-06-09 | |
| SPD544 High Strength Bioequivalence Study SPD544, Methylphenidate hydrochloride - ADHD | Phase 1 | Completed | Shire | 28 | 2010-08-27 | 2021-06-09 |
| Methylphenidate HCl or Modafinil in Treating Young Patients With Excessive Daytime Sleepiness After Cancer Therapy methylphenidate hydrochloride, modafinil, placebo - Central Nervous System Tumor, Pediatric, Fatigue | Phase 2 | Terminated | University of South Florida | 1 | 2010-07-01 | 2014-02-21 |
| Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors Methylphenidate, Placebo - ALL, Childhood, Leukemia, Lymphoblastic | Not applicable | Terminated | University of Minnesota | 1 | 2010-05-01 | 2015-03-27 |
| Randomized, Double-blind Safety and Efficacy Study of Lisdexamfetamine Dimesylate (LDX) in Children and Adolescents Aged 6-17 Lisdexamfetamine Dimesylate (LDX), Methylphenidate Hydrochloride, Placebo - ADHD | Phase 3 | Completed | Shire | 336 | 2008-11-17 | 2021-06-14 |
| Quality Assurance of Administering Methylphenidate in Adults With Attention Deficit Hyperactivity Disorder (ADHD) - QUMEA methylphenidate hydrochloride, Placebo - Attention Deficit Hyperactivity Disorder | Phase 3 | Completed | Medice Arzneimittel Pütter GmbH & Co KG | 150 | 2008-09-01 | 2010-01-13 |
| Methylphenidate in Treating Patients With Fatigue Caused by Cancer methylphenidate hydrochloride, placebo - Fatigue, Unspecified Adult Solid Tumor, Protocol Specific | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 148 | 2008-02-01 | 2016-08-01 |
| Efficacy Study of Methylphenidate Hydrochloride to Reduce Fatigue in Prostate Cancer Patients Receiving Hormone Therapy Methylphenidate Hydrochloride, Matched Placebo - Prostatic Neoplasms, Fatigue | Phase 2 | Terminated | University Health Network, Toronto | 33 | 2008-01-01 | 2014-06-04 |
| Methylphenidate Treatment of Cancer-Related Fatigue Methylphenidate hydrochloride, Placebo - Cancer-related Fatigue | Phase 2 / Phase 3 | Completed | Medice Arzneimittel Pütter GmbH & Co KG | 66 | 2006-08-01 | 2010-01-13 |
| Study Examining Repeat Dosing of OROS® Methylphenidate (CONCERTA®) and Immediate Release Methylphenidate in Healthy Adults OROS methylphenidate hydrochloride, methylphenidate hydrochloride - Healthy | Phase 3 | Completed | Massachusetts General Hospital | 20 | 2006-06-01 | 2013-10-22 |
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Attention Deficit Disorder with Hyperactivity (16) · Fatigue (9) · Brain Neoplasms (2) · Central Nervous System Neoplasms (2) · Depression (2) · Prostatic Neoplasms (2) · Sleep Wake Disorders (2) · Apraxias (1) · Astrocytoma (1) · Attention Deficit and Disruptive Behavior Disorders (1) · Breast Neoplasms (1) · Conduct Disorder (1) · Developmental Disabilities (1) · Ependymoma (1) · Fetal Alcohol Spectrum Disorders (1)
M.D. Anderson Cancer Center (4) · Shire (4) · Massachusetts General Hospital (3) · Medice Arzneimittel Pütter GmbH & Co KG (3) · Eli Lilly and Company (2) · University of South Florida (2) · Alliance for Clinical Trials in Oncology (1) · Eastern Cooperative Oncology Group (1) · Janssen Korea, Ltd., Korea (1) · Janssen Pharmaceutica N.V., Belgium (1) · McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc. (1) · Monash Medical Centre (1) · Murdoch Childrens Research Institute (1) · National Institute of Mental Health (NIMH) (1) · Novartis (1)
United States (15) · Germany (6) · Canada (3) · Australia (2) · Hungary (2) · Netherlands (2) · South Korea (2) · Sweden (2) · United Kingdom (2) · Belgium (1) · China (1) · France (1) · Israel (1) · Italy (1) · Mexico (1)
Thomas Spencer, MD (3) · Alicia Kunin-Batson, Ph.D. (1) · Alison Crichton, PhD (1) · Amit Sood, MD (1) · Angela Morgan, PhD (1) · Carmen Escalante, MD (1) · Eduardo Bruera, MD (1) · Edward G. Shaw, MD (1) · Elon Eisenberg, MD (1) · Gerald Rosen, MD (1) · James J Blair, Ph.D. (1)
PMID 28980198, PMID 16389216, PMID 18206857, PMID 20578931, PMID 20625123, PMID 22780962, PMID 23332456, PMID 23708466, PMID 23893527, PMID 24684534, PMID 26409610, PMID 31924662, PMID 38631835
U10CA081920 (2), 2008 (1)