11 completed, 11 unknown, 3 withdrawn, 2 recruiting. 20 Phase 2, 15 Phase 1, 2 Phase 3, 1 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Exploratory Study of ADR-002K for Heart Failure Patients With Ischemic Heart Disease Who Undergo CABG Mesenchymal stem cell, Placebo - Ischemic Heart Disease | Phase 2 | Recruiting | Rohto Pharmaceutical Co., Ltd. | 50 | 2026-04-28 | 2026-06-09 |
| Mesenchymal Stem Cells Treatment for AIDS Patients at Late Stage mesenchymal stem cell, saline - AIDS | Phase 1 / Phase 2 | Recruiting | Cell Energy Life Sciences Group Co. LTD | 150 | 2023-12-10 | 2025-08-12 |
| Mesenchymal Stromal Cells for the Treatment of Patients With COVID-19. Mesenchymal stem cell, Placebo - COVID-19 Pneumonia, COVID-19 | Phase 1 / Phase 2 | Withdrawn | Paulo Brofman | 2022-05-01 | 2025-02-10 | |
| A Study of ADR-001 in Patients With Severe Pneumonia Caused by SARS-CoV-2 Infection (COVID-19) Mesenchymal stem cell, Placebo - SARS-CoV-2 Infection( COVID-19 ) | Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 15 | 2021-06-15 | 2023-11-18 |
| Mesenchymal Stem Cells in Rotator Cuff Repair Mesenchymal stem cell, Rotator cuff repair - Rotator Cuff Tear, Tendon Injuries | Phase 2 | Suspended | University of Sao Paulo | 44 | 2020-11-01 | 2022-10-19 |
| Phase 2B Clinical Study of Chondrogen for Treatment of Knee Osteoarthritis Chondrogen, Placebo - Osteoarthritis, Knee | Phase 2 | Unknown | Meluha Life Sciences SDN BHD | 100 | 2020-10-31 | 2020-08-20 |
| An Exploratory Study of ADR-001 in Patients with Severe Pneumonia Caused by SARS-CoV-2 Infection Mesenchymal stem cell - Severe Acute Respiratory Syndrome Coronavirus 2 | Phase 1 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2020-08-21 | 2024-12-09 |
| Evaluation of Clinical and Bone Density Improvement After Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord on Osteoporosis Patients Mesenchymal Stem Cell - Osteoporosis | Phase 2 | Unknown | Ahmad Jabir Rahyussalim | 5 | 2020-08-01 | 2020-08-07 |
| Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia Best Practice, Mesenchymal Stem Cell - COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 65 | 2020-07-29 | 2026-10-05 |
| NestaCell® Mesenchymal Stem Cell to Treat Patients With Severe COVID-19 Pneumonia NestaCell®, Placebo - COVID-19 Pneumonia | Phase 2 | Completed | Azidus Brasil | 90 | 2020-06-30 | 2022-10-28 |
| The Effects of Stromal Vascular Fraction and Mesenchymal Stem Cells as Intra-articular Injection in Knee Joint Osteoarthritis Mesenchymal stem cell, Placebo - Osteoarthritis | Phase 2 | Withdrawn | SCARM Institute, Tabriz, Iran | 2019-11-10 | 2020-03-18 | |
| Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure Mesenchymal Stem Cell - Liver Failure, Acute on Chronic | Phase 1 / Phase 2 | Unknown | Tianjin Weikai Bioeng., Ltd. | 45 | 2019-10-01 | 2019-03-20 |
| An Follow-Up Study of Liver Cirrhosis Mesenchymal Stem Cell - Decompensated Liver Cirrhosis | Completed | Rohto Pharmaceutical Co., Ltd. | 19 | 2018-03-07 | 2023-11-18 | |
| Trial of Mesenchymal Stem Cell Transplantation in Decompensated Liver Cirrhosis mesenchymal stem cell transplantation via peripheral vein, mesenchymal stem cell - Liver Cirrhosis | Not applicable | Unknown | Xijing Hospital of Digestive Diseases | 200 | 2017-11-08 | 2018-09-11 |
| A Study of ADR-001 in Patients With Liver Cirrhosis Mesenchymal stem cell - Decompensated Liver Cirrhosis | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 21 | 2017-07-20 | 2023-07-06 |
| A Perspective Multicenter Controlled Study On Application Of Mesenchymal Stem Cell(MSC) To Prevent Rejection After Renal Transplantation By Donation After Cardiac Death mesenchymal stem cell - Disorder Related to Renal Transplantation, Renal Transplant Rejection | Phase 1 | Unknown | Qipeng Sun | 260 | 2016-01-01 | 2015-07-03 |
| Mesenchymal Stemcells for Radiation Induced Xerostomia Mesenchymal stem cell, Isotonic NaCl - Xerostomia | Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 30 | 2015-08-08 | 2022-12-28 |
| Safety of Autologous Bone Marrow Derived Mesenchymal Stem Cells in Erectile Dysfunction mesenchymal stem cell - Erectile Dysfunction | Phase 1 | Completed | Pharmicell Co., Ltd. | 10 | 2015-07-01 | 2019-01-09 |
| Mesenchymal Stem Cell Injection in Amyotrophic Lateral Sclerosis mesenchymal stem cell - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Withdrawn | Alzahra Hospital, Iran | 2015-05-01 | 2016-01-14 | |
| Mesenchymal Stem Cells Therapy for Treatment of Airway Remodeling in Mustard Patients mesenchymal stem cell - Pulmonary Disease | Phase 1 | Unknown | Dr. Mostafa Ghanei | 10 | 2015-02-01 | 2016-07-25 |
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Osteoarthritis (3) · COVID-19 (2) · Liver Cirrhosis (2) · Acquired Immunodeficiency Syndrome (1) · Acute-On-Chronic Liver Failure (1) · Amyotrophic Lateral Sclerosis (1) · Arthritis (1) · Erectile Dysfunction (1) · Hematologic Neoplasms (1) · Ischemic Stroke (1) · Joint Diseases (1) · Lung Diseases (1) · Lupus Nephritis (1) · Musculoskeletal Diseases (1) · Myocardial Infarction (1)
Rohto Pharmaceutical Co., Ltd. (5) · Royan Institute (2) · Ahmad Jabir Rahyussalim (1) · Alzahra Hospital, Iran (1) · Asan Medical Center (1) · Azidus Brasil (1) · Cell Energy Life Sciences Group Co. LTD (1) · Chaitanya Hospital, Pune (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dr. Mostafa Ghanei (1) · Fuzhou General Hospital (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Meluha Life Sciences SDN BHD (1) · Organ Transplant Institute, China (1)
China (5) · Japan (5) · Iran (4) · South Korea (4) · Brazil (3) · United States (2) · India (1) · Indonesia (1) · Malaysia (1)
Hamid Gourabi, PhD (2) · Mohsen Emadeddin, MD (2) · Nasser Aghdami, MD,PhD (2) · Amanda Olson (1) · Badrul Akmal Hisham, MBBS (1) · Chungsu Kim, Ph.D (1) · Fu-Sheng Wang, Doctor (1) · Jianming Tan T Jianming, professor (1) · Mohammad Nouri, Ph.D (1) · Oh Young Bang, MD (1) · Okawa Sumito (1)
PMID 22807102, PMID 24083670, PMID 24326779, PMID 24431901, PMID 26058927, PMID 26881220, PMID 28143470, PMID 28270226, PMID 29145879, PMID 29514693, PMID 32935623, PMID 33472925, PMID 34074163, PMID 34183258, PMID 34326007, PMID 34583525, PMID 35313959, PMID 35341320, PMID 42048594