16 completed, 8 recruiting, 7 active not recruiting, 5 unknown. 16 Phase 3, 12 Phase 2, 6 Phase 4, 3 Phase 1, 2 Not applicable.
Follow Leuprorelin: new trials by email Literature Review of Leuprorelin trials Research Report on Leuprorelin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| QL1706 Plus Neoadjuvant Endocrine Therapy in HR-Positive/HER2-Negative Breast Cancer With a Poor Response to Neoadjuvant Chemotherapy Iparomlimab and Tuvonralimab (QL1706), Aromatase Inhibitor (AI), CDK4/6 inhibitor - Breast Cancer | Phase 2 | Not yet recruiting | Hebei Medical University Fourth Hospital | 40 | 2026-10-01 | 2026-08-26 |
| A Phase Ia Trial Comparing the Pharmacokinetics/Pharmacodynamics, Safety, and Preliminary Efficacy of HHK001 and Enantone in Patients With Endometriosis HHK001 (Leuprorelin Acetate Microspheres for Injection), Enantone (Leuprorelin Acetate Microspheres for Injection) - Endometriosis | Phase 1 | Not yet recruiting | The Third Xiangya Hospital of Central South University | 20 | 2026-08-31 | 2026-08-28 |
| A Study of Leuprorelin 1-Month (4-Week) Formulation in Children With Central Precocious Puberty Leuprorelin - Central Precocious Puberty | Phase 4 | Recruiting | LG Chem | 43 | 2026-08-01 | 2026-07-29 |
| Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial Biospecimen Collection, Electronic Health Record Review, Goserelin - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 75 | 2026-01-22 | 2026-06-23 |
| A Short-term Preoperative, Evaluating Activity and Safety of Elacestrant Monotherapy as Compared to Elacestrant + Ovarian Function Suppression (LHRH Agonist) in Premenopausal Patients With Stage I-II ER+/HER2- Breast Cancer Elacestrant, Leuprorelin - Breast Cancer | Phase 2 | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 140 | 2025-10-06 | 2025-12-01 |
| COACTION Trial - COmbination Androgen bloCkade in inTermediate to hIgh-risk prOstate caNcer Darolutamide Oral Tablet, leuprorelin - Prostate Cancer | Phase 4 | Active not recruiting | Brazilian Clinical Research Institute | 144 | 2025-02-17 | 2026-02-11 |
| REVELUTION-2: Relugolix+Abiraterone Acetate (AA) Versus Leuprolide+AA Cardiac Trial Abiraterone Acetate, Bicalutamide, Biospecimen Collection - Recurrent Prostate Carcinoma, Stage III Prostate Cancer AJCC v8 | Phase 3 | Recruiting | Emory University | 72 | 2025-01-31 | 2026-02-24 |
| Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer Biospecimen Collection, Contrast Agent, Leuprolide - Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 70 | 2024-08-12 | 2026-03-09 |
| Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial Abiraterone, Apalutamide, Biospecimen Collection - Recurrent Castration-Sensitive Prostate Carcinoma, Recurrent Prostate Cancer | Phase 2 | Recruiting | Mayo Clinic | 532 | 2024-06-03 | 2026-07-20 |
| Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect Leuprorelin - Cesarean Section; Dehiscence | Not applicable | Recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 94 | 2023-05-01 | 2026-04-24 |
| A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT leuprorelin, normal saline - Hematopoietic Stem Cell Transplantation, Premature Ovarian Failure | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 200 | 2023-03-01 | 2023-02-23 |
| Real World Evidence Study on Metastatic Prostate Cancer in the Pirkanmaa Hospital District in Finland abiraterone, enzalutamide, docetaxel - Metastatic Castration Sensitive Prostate Cancer (mCSPC), Metastatic Castration Resistant Prostate Cancer (mCRPC) | Completed | Pfizer | 1083 | 2023-02-13 | 2026-01-29 | |
| A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia KLH-2109, Leuprorelin - Uterine Fibroids (MeSH Heading: Leiomyoma) | Phase 3 | Completed | Kissei Pharmaceutical Co., Ltd. | 287 | 2022-10-11 | 2025-03-14 |
| A GnRH Agonist IN Pre-menopausal Women STudy to Treat Severe Polycystic Liver Disease Leuprorelin - Polycystic Liver Disease, Autosomal Dominant Polycystic Kidney | Phase 2 | Recruiting | University Medical Center Groningen | 36 | 2022-06-01 | 2022-11-04 |
| Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial Bicalutamide, Buserelin, Darolutamide - Prostate Adenocarcinoma | Phase 3 | Active not recruiting | NRG Oncology | 2050 | 2021-12-06 | 2026-08-17 |
| Exploratory Study of Molecular Profile-Associated Evidence Guided Precision Therapy for Salivary Gland Cancer（MAPS） Pyrotinib, Bicalutamide, Leuprorelin - Salivary Gland Neoplasms | Unknown | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 182 | 2021-07-30 | 2021-10-21 | |
| Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial Apalutamide, Bicalutamide, Biospecimen Collection - Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 | Phase 3 | Active not recruiting | NRG Oncology | 2753 | 2021-01-21 | 2026-08-17 |
| Androgen Deprivation Therapy for Oligo-recurrent Prostate Cancer in Addition to radioTherapy Radiotherapy, Leuprorelin - Prostate Cancer | Phase 3 | Active not recruiting | University Medical Center Groningen | 280 | 2020-03-19 | 2025-04-04 |
| Androgen Deprivation Therapy on Bone Mineral Density Change in Prostate Cancer Patients Leuprorelin, Goserelin, Triptorelin - Prostatic Neoplasms | Phase 4 | Unknown | Wonju Severance Christian Hospital | 164 | 2020-01-23 | 2021-07-29 |
| A Study to Assess the Safety and Efficacy of Enantone (Leuprorelin) in Central Precocious Puberty (CPP) Among Chinese Participants Enantone, GnRH agonist - Central Precocious Puberty | Completed | Takeda | 108 | 2017-06-24 | 2022-03-16 |
Showing 20 of 41. Sign in to see all of them.
Prostatic Neoplasms (16) · Breast Neoplasms (6) · Puberty, Precocious (4) · Endometriosis (2) · Leiomyoma (2) · Adenocarcinoma (1) · Adenomyosis (1) · Infertility (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Pedophilia (1) · Polycystic Kidney, Autosomal Dominant (1) · Polycystic liver disease (1) · Primary Ovarian Insufficiency (1) · Salivary Gland Neoplasms (1)
Takeda (6) · NRG Oncology (3) · Millennium Pharmaceuticals, Inc. (2) · Pfizer (2) · University Medical Center Groningen (2) · Abbott (1) · Brazilian Clinical Research Institute (1) · Eli Lilly and Company (1) · Emory University (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Hebei Medical University Fourth Hospital (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Japan Breast Cancer Research Group (1) · Kissei Pharmaceutical Co., Ltd. (1)
United States (13) · France (8) · Canada (5) · China (5) · Netherlands (5) · South Korea (4) · Japan (3) · Austria (2) · Brazil (2) · Finland (2) · Germany (2) · Italy (2) · Poland (2) · Spain (2) · Taiwan (2)
Dr Elke Bestel (1) · Fan Jiang, Dr (1) · Fernando C Maluf, MD (1) · Jacob J. Orme, MD, PhD (1) · Jens Huober, MD PhD (1) · Jinsung Park, MD. PhD. (1) · Keun Seok Lee, MD, PhD (1) · Kristof Chwalisz, MD, PhD (1) · Mark D Hurwitz (1) · Masakazu Toi, MD, PhD (1)
PMID 38421252, PMID 19167733, PMID 19963436, PMID 21518701, PMID 22025196, PMID 22296076, PMID 30741797, PMID 31899823, PMID 34385241, PMID 34941067, PMID 35405087, PMID 35501744, PMID 37119051, PMID 37851874, PMID 38320501, PMID 38421243, PMID 40140551, PMID 41124201, PMID 41349040, PMID 41364813, PMID 41698328, PMID 42117295, PMID 42221687, PMID 42333826, PMID 42406777
U10CA180868 (3), 2009 (1), 2014 (1), P30CA138292 (1), R01CA286127 (1), R01CA300454 (1)