10 completed, 5 recruiting, 2 terminated, 1 active not recruiting. 19 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 10, Recruiting 5, Terminated 2, Active not recruiting 1, Unknown 1 |
| Phase 2 | 5 | Completed 3, Recruiting 2 |
Follow Leflunomide: new trials by email Literature Review of Leflunomide trials Research Report on Leflunomide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes Leflunomide 10mg, Leflunomide 20mg, Decitabine - Myelodysplastic Syndromes | Phase 1 / Phase 2 | Recruiting | West Virginia University | 26 | 2025-07-15 | 2026-04-23 |
| Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer Biospecimen Collection, Cholestyramine, Computed Tomography - Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8 | Phase 1 | Recruiting | City of Hope Medical Center | 19 | 2024-06-10 | 2026-10-20 |
| Bioequivalence Study of Generic Leflunomide 20 mg Film-coated Tablets and Reference Product Under Fasting Conditions Leflunomide 20 mg Film-coated Tablet, ARAVA® 20 mg Film-coated Tablet - Healthy Volunteer | Phase 1 | Unknown | International Bio service | 48 | 2024-04-01 | 2024-01-29 |
| Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast Cancer Leflunomide - PTEN-Altered Advanced Solid Tumors and HER2 Negative Breast Cancer | Phase 1 | Recruiting | Deborah Doroshow | 23 | 2023-12-13 | 2026-06-15 |
| Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies Cholestyramine, Leflunomide, Steroid Therapy - Acute Graft Versus Host Disease, Hematopoietic and Lymphoid System Neoplasm | Phase 1 | Recruiting | City of Hope Medical Center | 18 | 2023-06-16 | 2026-07-08 |
| Leflunomide for Idiopathic Pulmonary Hemosiderosis in Children Leflunomide, Steroid Drug - Idiopathic Pulmonary Hemosiderosis, Leflunomide | Phase 1 / Phase 2 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 34 | 2023-06-01 | 2023-07-10 |
| Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy Best Practice, Leflunomide, Placebo Administration - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Completed | City of Hope Medical Center | 2 | 2021-01-07 | 2024-07-03 |
| Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease Leflunomide - Chronic Graft Versus Host Disease, Steroid Refractory Graft Versus Host Disease | Phase 1 | Active not recruiting | City of Hope Medical Center | 18 | 2020-09-14 | 2026-10-19 |
| Leflunomide in Mild COVID-19 Patients Leflunomide - COVID-19 | Phase 1 | Terminated | University of Chicago | 11 | 2020-05-05 | 2024-02-07 |
| Leflunomide in Previously Treated Metastatic Triple Negative Cancers Leflunomide - Breast Neoplasms, Breast Diseases | Phase 1 / Phase 2 | Completed | Joseph Sparano | 17 | 2019-04-16 | 2026-03-19 |
| Leflunomide in Treating Patients With Relapsed or Refractory Multiple Myeloma Laboratory Biomarker Analysis, Leflunomide, Pharmacological Study - Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma | Phase 1 / Phase 2 | Completed | City of Hope Medical Center | 12 | 2015-12-02 | 2023-10-10 |
| Leflunomide+Vemurafenib in V600 Mutant Met. Melanoma Vemurafenib, Leflunomide - Melanoma | Phase 1 | Terminated | Massachusetts General Hospital | 3 | 2012-07-01 | 2017-04-06 |
| Effect of Leflunomide on T Cell Proliferation in HIV-Infected Patients Leflunomide - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 41 | 2005-01-05 | 2017-07-02 |
| Bioavailability Study of Leflunomide Tablets Under Fed Conditions Leflunomide, ARAVA - To Determine Bioequivalence Under Fed Conditions | Phase 1 | Completed | Par Pharmaceutical, Inc. | 62 | 2003-12-01 | 2017-09-26 |
| Bioavailability Study of Leflunomide Tablets Under Fasting Conditions Leflunomide, ARAVA - To Determine the Bioequivalence Study Under Fasting | Phase 1 | Completed | Par Pharmaceutical, Inc. | 52 | 2003-06-01 | 2008-04-04 |
| To Demonstrate the Relative Bioavailability, Parallel Study Of Leflunomide 20 mg Tablets Under Fasting Conditions Leflunomide 20 mg Tablets (Geneva Pharmaceutical), Arava 20 mg Tablets (Aventis Pharmaceutical, Inc.) - Rheumatoid Arthritis, Psoriatic Arthritis | Phase 1 | Completed | Sandoz | 52 | 2002-09-01 | 2017-03-28 |
| Leflunomide 20 mg Tablets Under Fasting Conditions Leflunomide 20 mg Tablets, ARAVA™ 20 mg Tablets - Healthy | Phase 1 | Completed | Teva Pharmaceuticals USA | 84 | 2002-06-01 | 2024-08-20 |
| Leflunomide 20 mg Tablets, Non-Fasting ARAVA® 20 mg tablets, Leflunomide 20 mg Tablets - Healthy | Phase 1 | Completed | Teva Pharmaceuticals USA | 37 | 2002-04-01 | 2024-08-19 |
| A Phase I Study of SU101 in Pediatric Patients With Refractory Malignancy SU101 - Glioma, Sarcoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 1997-03-01 | 2008-03-04 |
Arthritis, Psoriatic (1) · Arthritis, Rheumatoid (1) · Breast Diseases (1) · Breast Neoplasms (1) · Bronchiolitis Obliterans Syndrome (1) · COVID-19 (1) · Fasting (1) · Glioma (1) · HIV Infections (1) · Hematologic Neoplasms (1) · Hemosiderosis, Pulmonary (1) · Lecithin Cholesterol Acyltransferase Deficiency (1) · Melanoma (1) · Multiple Myeloma (1) · Myelodysplastic Syndromes (1)
City of Hope Medical Center (5) · Par Pharmaceutical, Inc. (2) · Teva Pharmaceuticals USA (2) · Deborah Doroshow (1) · International Bio service (1) · Joseph Sparano (1) · Massachusetts General Hospital (1) · National Cancer Institute (NCI) (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Sandoz (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · University of Chicago (1) · West Virginia University (1)
United States (14) · China (1)
Amandeep Salhotra (1) · David B. Erasmus, M.D. (1) · Deborah Doroshow, MD, PhD (1) · James D. Carlson, Pharm.D. (1) · Joseph Sparano, MD (1) · Keith Flaherty, MD (1) · Konstantinos Sdrimas, MD (1) · Michael Millis, MD (1) · Michael Rosenzweig (1) · Monzr M. Al Malki (1) · Sanjeet S Dadwal (1) · So Ran Hong (1) · So Ran Hong, M.D. (1) · Uthai Suvanakoot (1) · Vincent Chung (1)
P30CA033572 (3)