43 completed, 18 unknown, 16 recruiting, 10 terminated. 26 Phase 2, 19 Phase 1, 19 Phase 3, 18 Phase 4, 13 Not applicable.
Follow Leflunomide: new trials by email Literature Review of Leflunomide trials Research Report on Leflunomide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Nicorandil on Rheumatoid Arthritis Patients Nicorandil Oral Tablet, Placebo, conventional synthetic antirheumatic drugs (cDMARDs) - Rheumatoid Arthritis (RA) | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 70 | 2026-09-06 | 2026-09-16 |
| Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty Methotrexate, Sulfasalazine, Hydroxychloroquine - Rheumatic Disease | Phase 2 | Recruiting | NYU Langone Health | 80 | 2025-12-12 | 2026-07-09 |
| Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes Leflunomide 10mg, Leflunomide 20mg, Decitabine - Myelodysplastic Syndromes | Phase 1 / Phase 2 | Recruiting | West Virginia University | 26 | 2025-07-15 | 2026-04-23 |
| A Study of the Effectiveness of Additional Risk Minimization Measures Related to ARAVA® (Leflunomide) in Saudi Arabia Leflunomide - Rheumatoid Arthritis, Psoriatic Arthritis | Completed | Sanofi | 302 | 2025-05-05 | 2026-06-11 | |
| Leflunomide to Prevent Cytomegalovirus Reactivation in Stem Cell Transplant Patients Leflunomide 20 mg - Hematologic Malignancies | Phase 2 | Recruiting | Tata Memorial Centre | 22 | 2024-10-18 | 2026-07-16 |
| Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer Biospecimen Collection, Cholestyramine, Computed Tomography - Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8 | Phase 1 | Recruiting | City of Hope Medical Center | 19 | 2024-06-10 | 2026-10-20 |
| Bioequivalence Study of Generic Leflunomide 20 mg Film-coated Tablets and Reference Product Under Fasting Conditions Leflunomide 20 mg Film-coated Tablet, ARAVA® 20 mg Film-coated Tablet - Healthy Volunteer | Phase 1 | Unknown | International Bio service | 48 | 2024-04-01 | 2024-01-29 |
| Comparative Study of Leflunomide Plus Methotrexate Versus Methotrexate Monotherapy in Refractory Polyarticular Juvenile Idiopathic Arthritis Patients Leflunomide plus Methotrexate, Methotrexate Monotherapy - Juvenile Idiopathic Arthritis, Polyarticular Juvenile Idiopathic Arthritis | Phase 4 | Completed | Bangladesh Medical University | 50 | 2024-03-01 | 2026-02-23 |
| Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast Cancer Leflunomide - PTEN-Altered Advanced Solid Tumors and HER2 Negative Breast Cancer | Phase 1 | Recruiting | Deborah Doroshow | 23 | 2023-12-13 | 2026-06-15 |
| Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations Leflunomide, The combination of MEK inhibitor + hydroxychloroquine( plaquenil) ± bevacizumab - RAS Mutation, Ras (Kras or Nras) Gene Mutation | Phase 2 | Unknown | N.N. Petrov National Medical Research Center of Oncology | 20 | 2023-10-03 | 2024-01-29 |
| Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant Leflunomide tablet - Musculoskeletal Disease Other, GVHD, Chronic | Phase 2 | Terminated | Tata Memorial Centre | 1 | 2023-09-18 | 2025-09-10 |
| Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies Cholestyramine, Leflunomide, Steroid Therapy - Acute Graft Versus Host Disease, Hematopoietic and Lymphoid System Neoplasm | Phase 1 | Recruiting | City of Hope Medical Center | 18 | 2023-06-16 | 2026-07-08 |
| The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus and Leflunomide in Treatment of BK Virus Infection in Kidney Transplantation Recipient Everolimus, reduced dose tacrolimus and Leflunomide - Kidney Transplant Infection, BK Virus Infection | Not applicable | Active not recruiting | King Chulalongkorn Memorial Hospital | 50 | 2023-06-15 | 2026-05-28 |
| Leflunomide for Idiopathic Pulmonary Hemosiderosis in Children Leflunomide, Steroid Drug - Idiopathic Pulmonary Hemosiderosis, Leflunomide | Phase 1 / Phase 2 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 34 | 2023-06-01 | 2023-07-10 |
| Leflunomide Treatment for MEN1 Patients - the LUMEN1 Trial Leflunomide 20 mg - MEN1 Gene Mutation | Not applicable | Terminated | University Hospital, Basel, Switzerland | 3 | 2023-05-02 | 2026-01-27 |
| Leflunomide for Henoch-Schonlein Purpura Leflunomide - Henoch-Schonlein Purpura | Not applicable | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 36 | 2023-01-01 | 2023-07-10 |
| Treatment Strategies for IgG4-RD Patients With Internal Organ Involvement Prednisone and Mycophenolate Mofetil, Mycophenolate Mofetil, Leflunomide - Autoimmune Diseases | Not applicable | Unknown | Peking Union Medical College Hospital | 60 | 2022-07-01 | 2024-05-28 |
| Treatment Strategies for IgG4-RD Patients With Superficial Organ Involvement glucocorticoid plus iguratimod, glucocorticoid plus leflunomide - Autoimmune Diseases | Not applicable | Recruiting | Peking Union Medical College Hospital | 60 | 2022-07-01 | 2026-04-07 |
| Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients Cholestyramine, Leflunomide - Smoldering Plasma Cell Myeloma | Phase 2 | Active not recruiting | City of Hope Medical Center | 27 | 2022-03-07 | 2026-04-30 |
| New Clinical End-points in Patients With Primary Sjögren's Syndrome Hydroxychloroquine 400mg/d, Leflunomide 20mg/d, Mycophenolate mofetil 2000mg/d - Primary Sjögren's Syndrome (pSS) | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2022-01-20 | 2024-11-01 |
Showing 20 of 93. Sign in to see all of them.
Arthritis, Rheumatoid (31) · Arthritis, Psoriatic (6) · Autoimmune Diseases (4) · Arthritis, Juvenile (3) · Immunoglobulin G4-Related Disease (3) · Recurrence (3) · Smoldering Multiple Myeloma (3) · Brain Neoplasms (2) · Bronchiolitis Obliterans Syndrome (2) · COVID-19 (2) · Central Nervous System Neoplasms (2) · Glioma (2) · Hematologic Neoplasms (2) · Inflammation (2) · Lupus Erythematosus, Systemic (2)
Sanofi (11) · City of Hope Medical Center (10) · Peking Union Medical College Hospital (3) · Pfizer (3) · Genentech, Inc. (2) · Jawaharlal Institute of Postgraduate Medical Education & Research (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Par Pharmaceutical, Inc. (2) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (2) · Tata Memorial Centre (2) · Teva Pharmaceuticals USA (2) · University of Nebraska (2) · University of Oxford (2) · Ain Shams University (1) · Ashford and St. Peter's Hospitals NHS Trust (1)
United States (35) · China (20) · France (6) · Mexico (5) · Poland (5) · Canada (4) · Czechia (4) · Germany (4) · Hungary (4) · India (4) · Italy (4) · Romania (4) · Russia (4) · Spain (4) · Sweden (4)
Michael A Rosenzweig (3) · Alison L. Hannah, MBBS (2) · James R O'Dell, MD (2) · Michael Rosenzweig (2) · Vir S Negi, DM (2) · Wen Zhang, MD (2) · Aihua Zhang, M.D. (1) · Amandeep Salhotra (1) · Ann Traynor, MD (1) · Bao Chun De (1) · Betty Diamond, MD (1) · Bevra Hahn, MD (1) · Choe Seong Choon (1)
PMID 34519964, PMID 10515382, PMID 10573044, PMID 12659416, PMID 15528753, PMID 15845896, PMID 18307672, PMID 19955306, PMID 20689824, PMID 20837781, PMID 22093814, PMID 22389919, PMID 22859346, PMID 23118111, PMID 23146063, PMID 23401601, PMID 24299607, PMID 24498318, PMID 25359150, PMID 25359382, PMID 25790744, PMID 25889222, PMID 25949314, PMID 26591677, PMID 27047808, PMID 27418009, PMID 27432356, PMID 27682069, PMID 27860410, PMID 28326189, PMID 28544502, PMID 28986189, PMID 29190347, PMID 29209946, PMID 29211658, PMID 29244149, PMID 29556418, PMID 30590833, PMID 30649524, PMID 30877216, PMID 31054984, PMID 31153807, PMID 31197255, PMID 31236568, PMID 32017805, PMID 32113839, PMID 32166429, PMID 32202631, PMID 32241795, PMID 32268821
P30CA033572 (5), 2005 (2), 2008 (1), 2017 (1)