14 completed, 3 terminated, 3 withdrawn, 1 not yet recruiting. 9 Phase 2, 6 Phase 3, 5 Phase 1, 1 Early Phase 1, 1 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of First-line Gemcitabine and Nab-paclitaxel With or Without L-glutamine in Advanced Pancreatic Cancer Gemcitabine (1000 mg/m2), Nab-paclitaxel, L-glutamine - Pancreatic Cancer | Phase 2 | Not yet recruiting | Jun Gong, MD | 200 | 2026-12-01 | 2026-10-08 |
| Effect of L-Glutamine on Pulmonary Artery Pressure in Patients With Non-Transfusion-Dependent Thalassemia L-glutamine - Pulmonary Artery Pressure, Thalassemia | Phase 2 / Phase 3 | Completed | Mazandaran University of Medical Sciences | 8 | 2023-08-15 | 2025-10-07 |
| Trial of First-line L-glutamine With Gemcitabine and Nab-paclitaxel in Advanced Pancreatic Cancer Gemcitabine, Nab-paclitaxel, L-glutamine - Advanced Pancreatic Adenocarcinoma, Pancreatic Cancer | Phase 1 | Completed | Jun Gong, MD | 18 | 2021-05-13 | 2025-08-06 |
| Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patients L-glutamine - Sickle Cell Disease, Pharmacokinetics | Phase 4 | Completed | Emmaus Medical, Inc. | 13 | 2021-01-04 | 2022-08-02 |
| Glutamine Supplementation in People With Immune Dysregulation L-glutamine - Eczema, MTOROC1 Signaling | Early Phase 1 | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2020-03-12 | 2020-03-16 | |
| L-glutamine Treatment in Patients With Diverticulosis L-glutamine - Diverticulosis, Colonic | Phase 1 | Completed | Emmaus Medical, Inc. | 9 | 2019-07-19 | 2023-02-16 |
| The Effect of Pharmaceutical Grade L-glutamine (Endari) on Glycemic Control in Patients With Diabetes Mellitus Type II L-glutamine, No L-glutamine - Diabetes Mellitus, Type 2 | Phase 1 | Unknown | Hawaii Pacific Health | 25 | 2019-05-01 | 2019-05-13 |
| Trial of Enteral Glutamine on Intestinal Permeability in Critically Ill Patients Glutamin, Maltodextrin - Critical Illness, Enteral Nutrition | Phase 3 | Completed | Shahid Beheshti University | 60 | 2017-04-01 | 2018-04-10 |
| Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients Glutamin, Maltodextrin - Critical Illness, Enteral Nutrition | Phase 3 | Completed | Shahid Beheshti University | 200 | 2016-11-10 | 2018-10-16 |
| L-glutamine Supplementation to Alleviate Symptoms of Taxane-Induced Neuropathy in Patients With Breast Cancer L-glutamine - Peripheral Neuropathy | Phase 1 | Withdrawn | Eastern Regional Medical Center | 2014-08-01 | 2017-07-12 | |
| Glutamine in Preventing Peripheral Neuropathy in Patients With Multiple Myeloma Receiving Bortezomib glutamine, quality-of-life assessment, placebo - Chemotherapeutic Agent Toxicity, Multiple Myeloma | Phase 2 | Terminated | Beth Faiman | 9 | 2013-02-01 | 2019-10-22 |
| Glutamine to Improve Outcomes in Cardiac Surgery Glutamine, Maltodextrin - Nosocomial Infection | Not applicable | Completed | University of Alberta | 60 | 2012-09-01 | 2017-02-08 |
| A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis of Oxaliplatin Glutamine - Colorectal Carcinoma, Neoplasms, Colorectal | Phase 2 | Withdrawn | AHS Cancer Control Alberta | 2011-10-01 | 2016-02-24 | |
| Glutamine for the Treatment of Patients With Irritable Bowel Syndrome Glutamine - Diarrhea-Predominant Irritable Bowel Syndrome | Phase 2 | Completed | Tulane University | 106 | 2010-11-01 | 2017-08-09 |
| A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia L-glutamine, Placebo - Sickle Cell Anemia, Sickle ß0-Thalassemia | Phase 3 | Completed | Emmaus Medical, Inc. | 230 | 2010-05-01 | 2020-08-19 |
| Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension L-Glutamine - Pulmonary Hypertension, Sickle Cell Disease | Phase 2 | Completed | UCSF Benioff Children's Hospital Oakland | 13 | 2009-03-01 | 2021-06-10 |
| Effect of Oral Glutamine on Muscle Mass and Function in Duchenne Muscular Dystrophy L-Glutamine, placebo - Muscular Dystrophy, Duchenne | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 30 | 2006-02-01 | 2007-12-21 |
| Effect of Glutamine on Intestinal Permeability in Crohn's Disease Glutamine, Whey protein - Crohn's Disease | Phase 1 | Completed | All India Institute of Medical Sciences | 30 | 2005-11-01 | 2009-02-06 |
| L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia L-glutamine, Placebo - Sickle Cell Anemia, Thalassemia | Phase 2 | Completed | Emmaus Medical, Inc. | 70 | 2004-03-01 | 2021-01-29 |
| L-Glutamine Therapy for Sickle Cell Anemia L-Glutamine, Placebo - Sickle Cell Anemia, Thalassemia | Phase 2 | Terminated | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 15 | 2004-02-06 | 2021-02-02 |
Showing 20 of 22. Sign in to see all of them.
Anemia, Sickle Cell (5) · Thalassemia (4) · Critical Illness (2) · Pancreatic Neoplasms (2) · Peripheral Nervous System Diseases (2) · Breast Neoplasms (1) · Colorectal Neoplasms (1) · Crohn Disease (1) · Cross Infection (1) · Diabetes Mellitus, Type 2 (1) · Diverticulosis, Colonic (1) · Eczema (1) · Head and Neck Neoplasms (1) · Hyperphagia (1) · Hypertension, Pulmonary (1)
Emmaus Medical, Inc. (4) · Jun Gong, MD (2) · Shahid Beheshti University (2) · AHS Cancer Control Alberta (1) · All India Institute of Medical Sciences (1) · Assistance Publique - Hôpitaux de Paris (1) · Beth Faiman (1) · Eastern Regional Medical Center (1) · Hawaii Pacific Health (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · Mazandaran University of Medical Sciences (1) · NICHD Neonatal Research Network (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · SWOG Cancer Research Network (1) · Tulane University (1)
United States (14) · Iran (3) · Canada (2) · France (1) · India (1)
Yutaka Niihara, MD (3) · Jun Gong, MD (2) · Zahra Vahdat Shariatpanahi, MD, PhD (2) · Abbot R. Laptook, MD (1) · Augusta Saulys, MD (1) · Avroy A. Fanaroff, MD (1) · Barbara J. Stoll, MD (1) · Beth Faiman (1) · Brenda B. Poindexter, MD MS (1) · Charles R. Bauer, MD (1) · Charles Zerez, MD, PhD (1) · Claudia Morris, MD (1) · David K. Stevenson, MD (1) · Edward F. Donovan, MD (1) · Gurmeet Singh (1)
PMID 38775255, PMID 12600870, PMID 15121931, PMID 16356432, PMID 16615955, PMID 16818526, PMID 17908750, PMID 18716628, PMID 19403482, PMID 19421321, PMID 30021096, PMID 30108163, PMID 33006765, PMID 38401036, PMID 42675216
M01RR000070 (1), M01RR000750 (1), M01RR000997 (1), M01RR001032 (1), M01RR006022 (1), M01RR008084 (1), U01HD036790 (1), U10CA037429 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD021415 (1), U10HD027851 (1), U10HD027853 (1)