5 terminated, 3 completed. 4 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Terminated 3, Completed 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Terminated 2 |
Follow isophosphamide mustard: new trials by email Literature Review of isophosphamide mustard trials Research Report on isophosphamide mustard
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adenoviral Vector Monotherapy or Combination With Chemotherapy in Subjects With Recurrent/Metastatic Breast Cancer. Ad-RTS-hIL-12 and Veledimex, Palifosfamide - Breast Cancer Nos Metastatic Recurrent | Phase 2 | Terminated | Alaunos Therapeutics | 12 | 2013-04-04 | 2025-08-28 |
| Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors palifosfamide - Adult Central Nervous System Germ Cell Tumor, Adult Teratoma | Phase 2 | Terminated | Indiana University | 5 | 2013-02-01 | 2015-07-02 |
| Study of Palifosfamide-tris in Combination With Carboplatin and Etoposide in Chemotherapy Naïve Patients With Extensive-Stage Small Cell Lung Cancer (The MATISSE Study) Carboplatin, Palifosfamide-tris, Etoposide - Extensive-Stage Small Cell Lung Cancer | Phase 3 | Terminated | Alaunos Therapeutics | 188 | 2012-06-08 | 2026-10-01 |
| Effect on QTc, Pharmacokinetics, Safety, and Preliminary Efficacy of Single-agent Palifosfamide-tris in Subjects With Advanced Solid Tumors palifosfamide-tris, Normal Saline - Advanced Solid Tumors | Phase 1 | Completed | Alaunos Therapeutics | 24 | 2011-06-01 | 2026-09-29 |
| Intravenous Palifosfamide-tris in Combination With Etoposide and Carboplatin in Patients With Malignancies palifosfamide-tris - Malignancy, Cancer | Phase 1 | Completed | Alaunos Therapeutics | 22 | 2010-12-01 | 2026-09-29 |
| Study of Palifosfamide-tris in Combination With Doxorubicin in Patients With Front-line Metastatic Soft Tissue Sarcoma Palifosfamide-Tris, doxorubicin, Placebo - Soft Tissue Sarcoma | Phase 3 | Terminated | Alaunos Therapeutics | 447 | 2010-08-16 | 2026-10-06 |
| A Study of Palifosfamide Tris Plus Doxorubicin Versus Doxorubicin in Unresectable or Metastatic Soft-tissue Sarcoma Palifosfamide-Tris, Doxorubicin - Soft Tissue Sarcoma | Phase 2 | Terminated | Alaunos Therapeutics | 67 | 2008-09-03 | 2026-10-05 |
| Study of ZIO-201 in Advanced Sarcoma ZIO-201 - Advanced Sarcoma | Phase 1 / Phase 2 | Completed | Alaunos Therapeutics | 54 | 2006-02-21 | 2026-10-05 |
Sarcoma (2) · Small Cell Lung Carcinoma (2) · Testicular Neoplasms (2) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Osteosarcoma (1) · Ovarian Neoplasms (1) · Teratoma (1) · Thymoma (1)
Alaunos Therapeutics (7) · Indiana University (1)
United States (8) · Italy (3) · Australia (2) · Canada (2) · France (2) · Israel (2) · Poland (2) · Romania (2) · Russia (2) · United Kingdom (2) · Argentina (1) · Belgium (1) · Brazil (1) · Chile (1) · Colombia (1)
Jaymes Holland (1) · Jonathan J Lewis, MD, PhD (1) · Jonathan Lewis, MD, PhD (1) · Lawrence H Einhorn, MD (1)