16 completed, 7 unknown, 5 recruiting, 4 active not recruiting. 10 Phase 3, 9 Phase 2, 7 Phase 1, 5 Not applicable, 1 Early Phase 1.
Follow Iodine-131: new trials by email Literature Review of Iodine-131 trials Research Report on Iodine-131
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer Decision Aid, Usual Care - Thyroid Cancer | Not applicable | Recruiting | Georgetown University | 408 | 2025-08-06 | 2026-01-08 |
| Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation Biospecimen Collection, Cobimetinib, Computed Tomography - Thyroid Gland Follicular Carcinoma, Thyroid Gland Oncocytic Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 21 | 2024-07-15 | 2026-02-02 |
| A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy Methimazole, Radioiodine or thyroidectomy - Graves' Orbitopathy | Phase 3 | Unknown | University of Pisa | 52 | 2023-03-02 | 2023-03-17 |
| Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC Selpercatinib, Sodium Iodine I-131, rhTSH - Thyroid Cancer, Thyroid Carcinoma | Phase 2 | Recruiting | Massachusetts General Hospital | 30 | 2023-03-01 | 2024-12-12 |
| Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer metformin, Radioactive iodine (I-131) - Thyroid Cancer | Phase 3 | Recruiting | Medical University of Bialystok | 160 | 2022-11-01 | 2026-10-21 |
| Radiofrequency Ablation Versus I-131 for Solitary Autonomous Thyroid Nodules Radiofrequency ablation, Radioactive iodine - Thyroid Nodule, Toxic or With Hyperthyroidism, Autonomous Thyroid Function | Phase 3 | Terminated | Rijnstate Hospital | 40 | 2021-11-17 | 2025-07-17 |
| rhTSH for Radioactive Iodine Remnant Ablation in Participants With Differentiated Thyroid Cancer (DTC) rhTSH, Radioiodine (131I) - Differentiated Thyroid Cancer | Phase 3 | Completed | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 390 | 2021-10-06 | 2026-09-08 |
| Anlotinib or Penpulimab in Combination With RAI for DTC Anlotinib hydrochloride, Sodium Iodide I 131, Penpulimab - Thyroid Cancer | Phase 2 | Unknown | Peking Union Medical College Hospital | 42 | 2021-09-15 | 2022-01-28 |
| Salivary dysfuncTion After Radioiodine Treatment Radioiodine - Thyroid Cancer | Completed | French Nuclear Safety and Radiation Protection Authority (ASNR) | 138 | 2020-09-02 | 2021-05-10 | |
| Treatment Efficacy and Safety of Low-dose Radioiodine Ablation for Intermediate-risk Differentiated Thyroid Carcinoma Radioiodine - Papillary Thyroid Cancer | Not applicable | Unknown | Zhujiang Hospital | 254 | 2020-04-20 | 2024-03-15 |
| The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer Thyrogen, I-131, I-124 - Thyroid Cancer | Phase 2 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 30 | 2019-07-29 | 2026-10-26 |
| Follow up for Patients With Thyroid Cancer Planed for Radioiodine Scan or Treatment radioiodine - Thyroid Cancer | Active not recruiting | Taichung Veterans General Hospital | 107 | 2018-06-06 | 2026-05-01 | |
| RAI Plus Immunotherapy for Recurrent/Metastatic Thyroid Cancers Durvalumab (Medi4736), Radioiodine (RAI) - Thyroid Cancer | Early Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 11 | 2017-07-10 | 2026-08-11 |
| SREBP1 as a Potential Biomarker Promotes Cell Proliferation and Invasion in Thyroid Cancer pathologic - Thyroid Cancer | Completed | People's Hospital of Zhengzhou University | 140 | 2016-01-16 | 2019-08-28 | |
| Low-dose Radioiodine Ablation in Graves' Disease Radioiodine - Thyroid Diseases | Completed | University of Pisa | 12 | 2016-01-01 | 2017-04-12 | |
| Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer Iodine I-131, Placebo Administration, Selumetinib - Metastatic Thyroid Gland Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma | Phase 2 | Completed | Academic and Community Cancer Research United | 60 | 2015-05-04 | 2024-07-26 |
| Effect of Childhood Radioiodine Therapy on Salivary Function Radioiodine - Xerostomia, Hyperthyroidism | Completed | Boston Children's Hospital | 70 | 2014-09-01 | 2017-06-26 | |
| Trametinib in Increasing Tumoral Iodine Incorporation in Patients With Recurrent or Metastatic Thyroid Cancer Computed Tomography, Iodine I 124, Iodine I-131 - Metastatic Thyroid Gland Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 34 | 2014-08-14 | 2026-08-28 |
| Differentiated Thyroid Cancer: is There a Need for Radioiodine Ablation in Low Risk Patients? rhTSH stimulation, I131, Follow up - Low Risk Differentiated Thyroid Cancer | Phase 3 | Active not recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 776 | 2013-05-13 | 2023-05-17 |
| Minimize Radioactive Iodine Ablation Of Remnant Thyroid in Differentiated Thyroid Cancer I131, I123 - Thyroid Neoplasms | Phase 2 / Phase 3 | Unknown | National Cancer Center, Korea | 556 | 2013-05-01 | 2017-01-20 |
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Thyroid Neoplasms (21) · Adenocarcinoma, Follicular (8) · Thyroid Cancer, Papillary (8) · Hyperthyroidism (4) · Graves Disease (2) · Graves Ophthalmopathy (2) · Thyroid Diseases (2) · Xerostomia (2) · Anemia, Refractory, with Excess of Blasts (1) · Exophthalmos (1) · Head and Neck Neoplasms (1) · Hodgkin Disease (1) · Hypothyroidism (1) · Infertility (1) · Leukemia, Myelomonocytic, Chronic (1)
Fred Hutchinson Cancer Center (2) · Memorial Sloan Kettering Cancer Center (2) · National Cancer Institute (NCI) (2) · University of Pisa (2) · Academic and Community Cancer Research United (1) · Assistance Publique - Hôpitaux de Paris (1) · Barwon Health (1) · Boston Children's Hospital (1) · City of Hope Medical Center (1) · French Nuclear Safety and Radiation Protection Authority (ASNR) (1) · Genzyme, a Sanofi Company (1) · Georgetown University (1) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Hospital de Clinicas de Porto Alegre (1) · Lucille P. Markey Cancer Center at University of Kentucky (1)
United States (16) · China (5) · France (3) · Australia (1) · Brazil (1) · Finland (1) · Iran (1) · Italy (1) · Netherlands (1) · Poland (1) · South Korea (1) · Switzerland (1) · Taiwan (1)
Alan L Ho (2) · Agnieszka Adamska, Assoc.Prof. (1) · Ajay Gopal (1) · Alan Ho, MD, PhD (1) · Ana L Maia, MD, PhD (1) · Brian J. Davis, M.D. (1) · Eun Kyung Lee, M.D.,Ph.D. (1) · Huijuan Feng, Master (1) · Jack R Wall, BMBS, FRACP, PhD (1) · Joanna Klubo-Gwiezdzinska, M.D. (1) · Johnnie Orozco (1) · Kenneth Ain, MD (1) · Laura Chow (1)
PMID 18382668, PMID 23984185, PMID 28662033, PMID 29099942, PMID 29912343, PMID 35263518, PMID 35867385, PMID 37300484, PMID 37939122, PMID 39586309
P01CA044991 (2), P30CA015704 (2), 4UH3DE031248-03 (1), N01CM62207 (1), P30CA008748 (1), P30CA015083 (1), P30CA016672 (1), P30CA033572 (1), P50CA091956 (1), P50CA172012 (1), R01CA184724 (1)