13 completed, 3 terminated, 2 unknown, 1 withdrawn. 19 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 13, Terminated 3, Unknown 2, Withdrawn 1 |
| Phase 2 | 9 | Completed 5, Terminated 2, Unknown 1, Withdrawn 1 |
Follow Interferon-alpha: new trials by email Literature Review of Interferon-alpha trials Research Report on Interferon-alpha
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer Chemokin Modulatory Regimen (5 MU/m2), Chemokin Modulatory Regimen (10 MU/m2), Chemokin Modulatory Regimen (20 MU/m2) - Colorectal Cancer, Colorectal Carcinoma | Phase 1 / Phase 2 | Terminated | Roswell Park Cancer Institute | 15 | 2012-10-01 | 2023-10-27 |
| Determining the Maximum Tolerated Dose of Low Dose Interferon-alpha in Conjunction With Nilotinib in Pretreated Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP) Nilotinib, interferon-alfa - Chronic Myeloid Leukemia | Phase 1 | Completed | Novartis Pharmaceuticals | 4 | 2012-04-01 | 2015-05-05 |
| Intratumoral Dendritic Cell Vaccination Combined With Local Radiotherapy in Patients With Recurrent Lymphoma. Autologous dendritic cells generated using GM-CSF, interferon alpha and LPS - Lymphoma | Phase 1 / Phase 2 | Withdrawn | Baylor Research Institute | 2008-07-01 | 2017-06-12 | |
| Palliative Radiofrequency Ablation in Metastatic Renal Cell Carcinoma Patients Radiofrequency ablation; Interferon-alpha, Radiofrequency ablation; Sunitinib maleate, Sunitinib maleate - Carcinoma, Renal Cell | Phase 1 / Phase 2 | Completed | Kidney Cancer Research Bureau | 114 | 2008-05-01 | 2014-02-13 |
| Safety and Tolerability Study of FolateImmune in Combination With Cytokines in Patients With Refractory or Metastatic Cancer EC90 (KLH-FITC), GPI-0100, EC17 (Folate-FITC) - Cancer | Phase 1 | Completed | Endocyte | 13 | 2005-09-01 | 2012-03-09 |
| Vaccine Therapy in Treating Patients With HER2/Neu Positive or Negative Stage IV Breast Cancer or Other HER2/Neu Positive Cancers allogeneic GM-CSF-secreting breast cancer vaccine, recombinant interferon alfa, cyclophosphamide - Breast Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 / Phase 2 | Terminated | Wiseman Research Initiatives LLC | 24 | 2004-11-01 | 2018-02-05 |
| Safety Study of Low Dose Interleukin 2 (IL-2) Plus PEG-IFN/RBV In Chronic Hepatitis C Virus Genotype I Interleukin 2, Ribavirin, Pegylated Interferon Alpha - Hepatitis C | Phase 1 | Terminated | Weill Medical College of Cornell University | 18 | 2004-03-01 | 2008-03-07 |
| Short-Term Low-Dose Interferon Alfa in Treating Patients With Cancer of the Urothelium Recombinant Interferon Alfa - Bladder Cancer, Urethral Cancer | Phase 1 | Completed | M.D. Anderson Cancer Center | 33 | 2003-12-01 | 2015-05-14 |
| Chemotherapy and Biological Therapy in Treating Patients With Locally Advanced or Metastatic Kidney Cancer recombinant interferon alfa, temsirolimus - Kidney Cancer | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 2002-04-01 | 2013-06-05 | |
| Biological Therapy and Chemotherapy in Treating Patients With Metastatic Kidney Cancer or Colorectal Cancer recombinant interferon alfa, sargramostim, therapeutic autologous lymphocytes - Colorectal Cancer, Kidney Cancer | Phase 1 / Phase 2 | Completed | St. Luke's Medical Center | 60 | 2001-11-01 | 2013-06-26 |
| Fluorouracil and Biological Therapy in Treating Patients With Metastatic Kidney or Colorectal Cancer lymphokine-activated killer cells, recombinant interferon alfa, sargramostim - Colorectal Cancer, Kidney Cancer | Phase 1 | Unknown | St. Luke's Medical Center | 2001-01-01 | 2013-09-20 | |
| Combination Therapy With 5-Fluorouracil, Interferon-an Interleukin-2, & Thalidomide for Metastatic, Advanced or Recurrent Renal Cell Carcinoma 5-Flourouracil, Interferon-a, IL-2 and Thalidomide - Kidney, Cancer | Phase 1 / Phase 2 | Completed | New Mexico Cancer Research Alliance | 15 | 2000-09-01 | 2011-09-27 |
| Interleukin-12 and Interferon Alfa in Treating Patients With Metastatic Kidney Cancer or Malignant Melanoma recombinant interferon alfa, recombinant interleukin-12 - Kidney Cancer, Melanoma (Skin) | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2000-03-01 | 2013-03-21 |
| Cisplatin, Gemcitabine, Interferon Alfa, and Hyperthermia in Treating Patients With Advanced Cancer recombinant interferon alfa, cisplatin, gemcitabine hydrochloride - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 / Phase 2 | Unknown | The University of Texas Health Science Center, Houston | 30 | 1999-08-01 | 2009-04-30 |
| Interleukin-12 Followed by Interferon Alfa in Treating Patients With Advanced Cancer recombinant interferon alfa, recombinant interleukin-12 - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 40 | 1998-08-01 | 2013-02-01 |
| Post-Operative Adjuvant Radiotherapy With Concurrent Interferon-Alfa Interferon alfa, Radiation therapy - Melanoma (Skin) | Phase 1 / Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 24 | 1997-07-01 | 2012-09-25 |
| Cisplatin, Interferon Alfa, Surgery, and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma recombinant interferon alfa, cisplatin, surgical procedure - Malignant Mesothelioma | Phase 1 | Completed | Fox Chase Cancer Center | 6 | 1996-08-01 | 2013-04-17 |
| Biological Therapy Plus Chemotherapy in Treating Patients With Metastatic or Recurrent Kidney Cancer aldesleukin, recombinant interferon alfa, fluorouracil - Kidney Cancer | Phase 1 / Phase 2 | Completed | University of New Mexico | 35 | 1996-08-01 | 2013-12-10 |
| Radiolabeled Monoclonal Antibody, Paclitaxel, and Interferon Alfa in Treating Patients With Recurrent Ovarian Cancer recombinant interferon alfa, chemotherapy, paclitaxel - Ovarian Cancer, Primary Peritoneal Cavity Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 1996-03-01 | 2013-02-05 |
Carcinoma, Renal Cell (7) · Kidney Neoplasms (5) · Colorectal Neoplasms (3) · Colonic Neoplasms (2) · Lymphoma (2) · Melanoma (2) · Neoplasms (2) · Rectal Neoplasms (2) · Recurrence (2) · Blast Crisis (1) · Breast Neoplasms (1) · Breast Neoplasms, Male (1) · Burkitt Lymphoma (1) · Carcinoma, Ovarian Epithelial (1) · Hepatitis C (1)
National Cancer Institute (NCI) (3) · St. Luke's Medical Center (2) · Baylor Research Institute (1) · Endocyte (1) · Fox Chase Cancer Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Kidney Cancer Research Bureau (1) · M.D. Anderson Cancer Center (1) · Memorial Sloan Kettering Cancer Center (1) · New Mexico Cancer Research Alliance (1) · Novartis Pharmaceuticals (1) · Roswell Park Cancer Institute (1) · The University of Texas Health Science Center, Houston (1) · University of New Mexico (1) · Weill Medical College of Cornell University (1)
United States (16) · Germany (1) · Russia (1)
John P. Hanson, MD (2) · Amer H Zureikat, MD (1) · Ashish M. Kamat, MD (1) · Bin Chung, MD (1) · Charles L. Wiseman, MD, FACP (1) · Corey J. Langer, MD (1) · Fa-Chyi Lee, MD (1) · Ilya V. Tsimafeyeu, MD (1) · Joan M.C. Bull, MD (1) · Karolina Palucka, MD, PhD (1) · Kendall A Smith, MD (1) · Laurence Elias, MD (1) · Richard A Messmann, MD, MHS, BSc (1) · Robert J. Motzer, MD (1)
P30CA006927 (1), P30CA016672 (1), P50CA091846 (1), U01AI048224 (1)