76 completed, 16 terminated, 11 unknown, 4 withdrawn. 108 Phase 2, 9 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 108 | Completed 76, Terminated 16, Unknown 11, Withdrawn 4, Active not recruiting 1 |
| Phase 1 | 9 | Completed 5, Terminated 2, Unknown 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
Follow Interferon-alpha: new trials by email Literature Review of Interferon-alpha trials Research Report on Interferon-alpha
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Interferon Alfa Therapy Based on Th17 Profile in Membranous Nephropathy Peginterferon Alfa-2A 180 MCG/ML Injectable Solution - Membranous Nephropathy | Phase 2 | Terminated | Centre Hospitalier Universitaire de Nice | 4 | 2023-09-14 | 2026-06-18 |
| Pharmaco-immunological Study of Interferon-alpha and Metronomic Cyclophosphamide Association in Neuroendocrine Tumors Metronomic cyclophosphamide, Interferon-alpha - Neuroendocrine Tumors | Phase 2 | Completed | Centre Hospitalier Universitaire de Besancon | 28 | 2015-05-19 | 2021-08-02 |
| Adjuvant Therapy of Skin Melanoma With Alpha Interferon and Naderin Surgical resection, Adjuvant Radiotherapy, interferon alfa - Melanoma Stage I, Melanoma Stage III | Phase 2 | Completed | MIPO Clinic | 278 | 2014-01-01 | 2026-06-30 |
| P2 Study of Postoperative Interferon/Fluorouracil vs Cisplatin/Fluorouracil for Hepatocellular Carcinoma. Interferon Alfa、Fluorouracil, Cisplatin、Fluorouracil - Hepatocellular Carcinoma | Phase 2 | Unknown | Kansai Hepatobiliary Oncology Group | 66 | 2013-03-01 | 2018-05-18 |
| Pegylated Interferon Alpha-2b in Early Primary Myelofibrosis Peginterferon alfa-2a - Myelofibrosis | Phase 2 | Terminated | Weill Medical College of Cornell University | 8 | 2013-01-01 | 2018-07-24 |
| Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer Chemokin Modulatory Regimen (5 MU/m2), Chemokin Modulatory Regimen (10 MU/m2), Chemokin Modulatory Regimen (20 MU/m2) - Colorectal Cancer, Colorectal Carcinoma | Phase 1 / Phase 2 | Terminated | Roswell Park Cancer Institute | 15 | 2012-10-01 | 2023-10-27 |
| Interferon Alpha Lozenges Plus Oseltamivir for Influenza Treatment Interferon-alpha, Oseltamivir, maltose - Influenza A Virus Infection | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 40 | 2011-01-01 | 2013-08-21 |
| Interferon-alpha Lozenges for Prevention of Relapse in Hepatitis C interferon-alpha lozenges, placebo lozenges - Hepatitis C, Chronic | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 169 | 2009-06-01 | 2024-02-21 |
| Interferon Alpha Lozenges in the Prevention of Winter Colds and Flu interferon-alpha, placebo - Upper Respiratory Tract Infections | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 200 | 2009-04-01 | 2011-09-16 |
| Borderline Resectable Pancreatic Cancer: Gemcitabine/Docetaxel and Oxaliplatin Based Chemo/RT Gemcitabine, Docetaxel, 5FU, Oxaliplatin, Alpha-interferon, Abdominal/pelvic radiation therapy - Pancreatic Cancer | Phase 2 | Completed | Benaroya Research Institute | 40 | 2008-09-01 | 2010-05-26 |
| Intratumoral Dendritic Cell Vaccination Combined With Local Radiotherapy in Patients With Recurrent Lymphoma. Autologous dendritic cells generated using GM-CSF, interferon alpha and LPS - Lymphoma | Phase 1 / Phase 2 | Withdrawn | Baylor Research Institute | 2008-07-01 | 2017-06-12 | |
| Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis interferon-alpha lozenges, placebo lozenges - Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis | Phase 2 | Terminated | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 1 | 2008-06-01 | 2012-04-24 |
| Palliative Radiofrequency Ablation in Metastatic Renal Cell Carcinoma Patients Radiofrequency ablation; Interferon-alpha, Radiofrequency ablation; Sunitinib maleate, Sunitinib maleate - Carcinoma, Renal Cell | Phase 1 / Phase 2 | Completed | Kidney Cancer Research Bureau | 114 | 2008-05-01 | 2014-02-13 |
| A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive Metastatic Renal Cell Carcinoma EC90 (KLH-FITC), GPI-0100, EC17 (Folate-FITC) - Renal Cell Carcinoma | Phase 2 | Terminated | Endocyte | 12 | 2007-06-01 | 2012-03-08 |
| Treatment of Oral Warts in HIV+ Patients Interferon-alpha, placebo - Papillomatosis, HIV Infections | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 59 | 2007-02-01 | 2011-09-16 |
| ABR-217620/Naptumomab Estafenatox With Interferon-alpha (IFN-alpha) Compared to IFN-alpha Alone in Patients With Advanced Renal Cell Carcinoma ABR-217620/naptumomab estafenatox, IFN-alpha - Renal Cell Carcinoma | Phase 2 / Phase 3 | Completed | Active Biotech AB | 526 | 2007-01-01 | 2015-07-22 |
| Capecitabine and Interferon-Alpha in Metastatic Renal Cell Carcinoma Patients With Failure on Interleukin-2 Based Regimens capecitabine, interferon-alpha - Carcinoma, Renal Cell | Phase 2 | Completed | Kidney Cancer Research Bureau | 49 | 2006-12-01 | 2009-05-01 |
| Interferon and GM-CSF Compared With Imatinib Mesylate and Vaccine Therapy in Patients With Chronic Phase CML on a TKI GM-K562 cell vaccine, Interferon alfa, Sargramostim - Leukemia | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 36 | 2006-09-01 | 2018-11-13 |
| Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal Cancer TroVax® (Immunological Vaccine Therapy), Interferon-alpha - Carcinoma, Renal Cell | Phase 2 | Completed | The Methodist Hospital Research Institute | 28 | 2006-05-01 | 2016-03-17 |
| Interferon-Induced Gene Expression in Liver Cells and Peripheral Blood Lymphocytes Interferon alpha - Hepatitis C | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2 | 2006-05-01 | 2010-08-27 |
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Carcinoma, Renal Cell (20) · Leukemia (19) · Kidney Neoplasms (15) · Leukemia, Myeloid, Chronic-Phase (15) · Melanoma (13) · Multiple Myeloma (12) · Lymphoma (11) · Neoplasms, Plasma Cell (10) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (9) · Pancreatic Neoplasms (9) · Lymphoma, Follicular (7) · Burkitt Lymphoma (5) · Leukemia, Lymphocytic, Chronic, B-Cell (5) · Leukemia, Myeloid, Accelerated Phase (5) · Neoplasms (5)
National Cancer Institute (NCI) (9) · Hoag Memorial Hospital Presbyterian (6) · M.D. Anderson Cancer Center (6) · Ainos, Inc. (f/k/a Amarillo Biosciences Inc. (5) · Eastern Cooperative Oncology Group (4) · Fred Hutchinson Cancer Center (4) · Masonic Cancer Center, University of Minnesota (4) · SWOG Cancer Research Network (4) · The University of Texas Health Science Center, Houston (4) · Kidney Cancer Research Bureau (3) · Memorial Sloan Kettering Cancer Center (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · City of Hope Medical Center (2) · Herbert Irving Comprehensive Cancer Center (2) · Northwestern University (2)
United States (90) · France (4) · Russia (4) · Switzerland (3) · United Kingdom (3) · Canada (2) · Germany (2) · Italy (2) · Portugal (2) · Taiwan (2) · Australia (1) · Austria (1) · Belgium (1) · Bulgaria (1) · Hungary (1)
Robert O. Dillman, MD, FACP (6) · Charles L. Wiseman, MD, FACP (3) · B. Douglas Smith, MD (2) · Catherine M. Verfaillie, MD (2) · Ilya V. Tsimafeyeu, MD (2) · Jane N. Winter, MD (2) · Joan M Bull, M.D. (2) · Joan M.C. Bull, MD (2) · Laura F. Hutchins, MD (2) · Leo I. Gordon, MD (2) · Scott Wadler, MD (2) · William Carson (2) · Aaron P. Rapoport, MD (1) · Adrian L. Harris, MD (1) · Ahmet Gul, MD (1)
PMID 12074329, PMID 14508361, PMID 14581348, PMID 15308571, PMID 16170182, PMID 16249352, PMID 16260693, PMID 16706633, PMID 17023156, PMID 17366595, PMID 17443000, PMID 17932881, PMID 18162124, PMID 18608594, PMID 18645482, PMID 18650621, PMID 19204798, PMID 19228745, PMID 19622576, PMID 19717547, PMID 21163569, PMID 21487108, PMID 22021080, PMID 24174627, PMID 24237300, PMID 25331113, PMID 25669986, PMID 29867922, PMID 32499241, PMID 33720337, PMID 37146227, PMID 38941593, PMID 41845569, PMID 8368765
P30CA016672 (4), P30CA006973 (3), U10CA032102 (3), P30CA033572 (2), M01RR002558 (1), N01CM17101 (1), N01CM62207 (1), P01CA075606 (1), P30CA013330 (1), P30CA016058 (1), P30CA023108 (1), R01CA095648 (1), R21CA093071 (1), U01CA062505 (1), U01CA070019 (1)