7 completed, 6 active not recruiting, 6 recruiting, 5 terminated. 12 Phase 2, 9 Phase 3, 6 Phase 1, 4 Not applicable.
Follow Intensity-Modulated Radiation Therapy (IMRT): new trials by email Literature Review of Intensity-Modulated Radiation Therapy (IMRT) trials Research Report on Intensity-Modulated Radiation Therapy (IMRT)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT) - Diffuse Intrinsic Pontine Gliomas (DIPG) | Phase 3 | Not yet recruiting | Shandong Cancer Hospital and Institute | 142 | 2026-12-01 | 2026-10-09 |
| Proton vs Photon IMRT in Locally Advanced Nasopharyngeal Carcinoma: A Phase III Trial Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT), Cisplatin - Nasopharyngeal Carcinoma (NPC) | Phase 3 | Recruiting | Man Hu | 300 | 2025-12-15 | 2026-01-14 |
| A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma Bicalutamide, Intensity-modulated radiation therapy (IMRT) - Recurrent Glioblastoma, Recurrent High-grade Glioma | Phase 1 | Withdrawn | University of Nebraska | 2025-04-08 | 2025-07-22 | |
| Induction Chemotherapy Response-Guided Radiation for EBV-Associated Nasopharyngeal Carcinoma Intensity-Modulated Radiation Therapy (IMRT), Radiographic Imaging, Biospecimen Collection - Nasopharyngeal Carcinoma, Stage III Nasopharyngeal Carcinoma AJCC v8 | Not applicable | Recruiting | University of California, San Francisco | 66 | 2025-03-18 | 2026-06-17 |
| Radiotherapy to Patients With CA19-9-elevated Advanced Pancreatic Cancer Gemcitabine, Nab-paclitaxel, Irinotecan, Intensity-Modulated Radiation Therapy (IMRT) - Pancreatic Adenocarcinoma | Phase 3 | Recruiting | Fudan University | 210 | 2024-05-15 | 2025-08-07 |
| Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX) Xevinapant, Cisplatin, intensity-modulated radiation therapy (IMRT) - Head and Neck Cancer | Phase 1 | Terminated | EMD Serono Research & Development Institute, Inc. | 18 | 2024-01-18 | 2025-09-29 |
| A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa. Hypofractionated Radiation Therapy, Conservative treatment - Soft Tissue Sarcoma | Phase 2 | Recruiting | Institut Claudius Regaud | 48 | 2023-11-28 | 2026-06-02 |
| A Study of SYH2051 Monotherapy in Advanced Solid Tumors or in Combination With Radiotherapy in Locally Advanced Head and Neck Cancer SYH2051 tablets, Intensity-Modulated Radiation Therapy (IMRT) - Solid Tumors, Head and Neck Cancer | Phase 1 | Unknown | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 73 | 2023-08-15 | 2023-10-27 |
| Induction Chemotherapy Followed by IMRT or Concurrent Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma Gemcitabine,Cisplatin, Intensity-modulated radiation therapy (IMRT), Cisplatin - Nasopharyngeal Carcinoma | Phase 3 | Recruiting | Wei Jiang | 440 | 2022-11-11 | 2023-05-03 |
| De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx Intensity-Modulated Radiation Therapy (IMRT) - HPV Positive Oropharyngeal Squamous Cell Carcinoma | Recruiting | University of California, Irvine | 111 | 2022-11-03 | 2026-05-05 | |
| Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Temozolomide - Glioblastoma, Gliosarcoma | Phase 1 | Terminated | Barbara Ann Karmanos Cancer Institute | 2 | 2021-08-12 | 2025-01-15 |
| HYPORT: A Phase I/II Study of Hypofractionated Post-operative Radiation Therapy for Head and Neck Cancer Intensity-modulated Radiation Therapy (IMRT) - Squamous Cell Carcinoma of Head and Neck | Phase 1 / Phase 2 | Active not recruiting | University of Texas Southwestern Medical Center | 59 | 2020-07-28 | 2026-05-06 |
| Ph 2 Open Label Study of GC4419 to Reduce SOM Associated With Chemoradiotherapy for Head and Neck Cancer Drug: GC4419, Intensity-modulated radiation therapy (IMRT), Cisplatin - Head and Neck Cancer, Oral Mucositis | Phase 2 | Completed | Galera Therapeutics, Inc. | 38 | 2020-06-30 | 2022-08-16 |
| Phase II Concurrent Durvalumab and Radiotherapy for for Stage III Non-Small Cell Lung Cancer Thoracic RT and Durvalumab, Consolidative Durvalumab - Non Small Cell Lung Cancer, Lung Cancer Stage III | Phase 2 | Completed | University of Texas Southwestern Medical Center | 10 | 2020-04-03 | 2025-03-21 |
| Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs Intensity-modulated radiation therapy (IMRT) - Soft Tissue Sarcoma | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 65 | 2020-02-26 | 2026-02-20 |
| Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma Intensity-Modulated Radiation Therapy (IMRT), Cisplatin, Nimorazole. - Oropharynx Cancer, Oropharynx Squamous Cell Carcinoma | Not applicable | Active not recruiting | Christian von Buchwald | 138 | 2019-03-01 | 2025-12-31 |
| Adjuvant Treatment of Apatinib in Nasopharyngeal Carcinoma Apatinib mesylate tablet, Intensity-modulated radiation therapy (IMRT), Cisplatin - Nasopharyngeal Carcinoma | Phase 2 | Unknown | Wei Jiang | 240 | 2018-07-01 | 2018-08-02 |
| Study Assessing The "Best of" Radiotherapy vs the "Best of" Surgery in Patients With Oropharyngeal Carcinoma Intensity-Modulated Radiation Therapy (IMRT), Trans Oral Surgery (TOS) - Oropharyngeal Cancer, Supraglottic Squamous Cell Carcinoma | Not applicable | Active not recruiting | European Organisation for Research and Treatment of Cancer - EORTC | 112 | 2017-11-27 | 2025-08-14 |
| Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy (3D-CRT), Docetaxel, Gemcitabine - Recurrent Non-Small Cell Lung Carcinoma, Stage IV Non-Small Cell Lung Cancer | Phase 2 | Active not recruiting | NRG Oncology | 218 | 2017-04-07 | 2026-06-08 |
| Induction Chemotherapy Followed by IMRT With or Without Concurrent Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma Docetaxel,Cisplatin,Fluorouracil, Intensity-modulated radiation therapy (IMRT), Cisplatin - Nasopharyngeal Carcinoma | Phase 3 | Unknown | Wei Jiang | 440 | 2015-03-01 | 2018-05-16 |
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Head and Neck Neoplasms (6) · Nasopharyngeal Carcinoma (5) · Squamous Cell Carcinoma of Head and Neck (4) · Oropharyngeal Neoplasms (3) · Prostatic Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Glioblastoma (2) · Papillomavirus Infections (2) · Sarcoma (2) · Brain Neoplasms (1) · Breast Neoplasms (1) · Carcinoma (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Carcinoma, Squamous Cell (1) · Central Nervous System Neoplasms (1)
Radiation Therapy Oncology Group (3) · Wei Jiang (3) · University of Texas Southwestern Medical Center (2) · Barbara Ann Karmanos Cancer Institute (1) · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (1) · Christian von Buchwald (1) · Drexel University College of Medicine (1) · EMD Serono Research & Development Institute, Inc. (1) · Eastern Cooperative Oncology Group (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fudan University (1) · Galera Therapeutics, Inc. (1) · Institut Claudius Regaud (1) · Man Hu (1) · Memorial Sloan Kettering Cancer Center (1)
United States (18) · China (7) · Canada (4) · Belgium (3) · Israel (3) · Spain (3) · Switzerland (3) · France (2) · Germany (2) · Poland (2) · South Korea (2) · Czechia (1) · Denmark (1) · Hong Kong (1) · Italy (1)
Wei Jiang, Ph.D. (2) · C. Leland Rogers, MD (1) · Carlos Vargas, MD (1) · Carmen Perez, M.D. (1) · Chi Zhang, MD (1) · Christian Simon (1) · Christian von Buchwald, MD, DMSc. (1) · Daniel Low, PhD (1) · Deborah W Bruner, RN, PhD (1) · Dominic Moon, MD (1) · Douglas W. Arthur, MD (1) · Eric Chen, MD (1) · Frank A. Vicini, MD, FACR (1) · Gary M. Freedman, MD (1) · Gregory P Swanson, MD (1)
PMID 25057165, PMID 24423462, PMID 26493095, PMID 27044935, PMID 27840089, PMID 28029303, PMID 28984517, PMID 30763425, PMID 31786276, PMID 32827580, PMID 33608212, PMID 35776901, PMID 36736921, PMID 36884035, PMID 37751207, PMID 38050737, PMID 38329737, PMID 38759121, PMID 39473059, PMID 42114027, PMID 42143623
2023 (1), U10CA023318 (1), U10CA180868 (1)