14 completed, 13 active not recruiting, 13 recruiting, 4 terminated. 29 Phase 2, 12 Not applicable, 7 Phase 3, 6 Phase 1.
Follow Hypofractionation: new trials by email Literature Review of Hypofractionation trials Research Report on Hypofractionation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypofractionated Definitive Chemoradiotherapy for Oesophageal Cancer Hypofractionation, carboplatin + paclitaxel (CP) - Locally Advanced Esophageal or GE Junction Cancer | Phase 2 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 60 | 2026-04-28 | 2026-06-08 |
| Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda Hypofractionated Radiation Therapy, Conventional Fractionated Radiotherapy, Cisplatin - Cervical Cancer, Cervix Cancer | Phase 2 | Recruiting | Uganda Cancer Institute | 278 | 2026-03-11 | 2026-03-27 |
| Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial Biospecimen Collection, Chemotherapy, Computed Tomography - Ewing Sarcoma, Round Cell Sarcoma With EWSR1-non-ETS Fusion | Not applicable | Recruiting | Mayo Clinic | 170 | 2025-12-05 | 2026-10-06 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-10-23 |
| Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer Biopsy of Breast, Biospecimen Collection, Breast Surgery - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 120 | 2025-05-14 | 2026-09-03 |
| Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma Bevacizumab, Biospecimen Collection, Computed Tomography - Recurrent Glioblastoma, Recurrent WHO Grade 4 Glioma | Phase 2 | Recruiting | Academic and Community Cancer Research United | 134 | 2024-10-02 | 2024-11-19 |
| Pre-operative Hypofractionated Proton Therapy hypofractionation - Soft Tissue Sarcoma | Not applicable | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 40 | 2024-04-18 | 2026-04-17 |
| SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma Antiandrogen Therapy, Biospecimen Collection, Hypofractionated Radiation Therapy - Biochemically Recurrent Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Phase 3 | Active not recruiting | Mayo Clinic | 118 | 2024-04-04 | 2026-09-17 |
| HYpofractionated Pelvic Radiotherapy for Advanced Cervical Cancers INeligible for ChemoTherapy Hypofractionation - Locally Advanced Cervical Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | University of Santo Tomas Hospital, Philippines | 55 | 2024-01-01 | 2023-01-31 |
| Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma Biospecimen Collection, Computed Tomography, Endoscopic Ultrasound - Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 99 | 2023-11-21 | 2026-10-01 |
| Hypofractionated Radiation Therapy After Durvalumab and Chemotherapy for the Treatment of Stage IV Extensive Stage Small Cell Lung Cancer, CASPIAN-RT Trial Carboplatin, Cisplatin, Durvalumab - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 2 | Withdrawn | University of Washington | 2023-10-19 | 2023-10-18 | |
| Hypofractionated Radiotherapy in Breast Cancer Patients With Prosthetic Reconstruction Hypofractionation - Breast Cancer | Not applicable | Recruiting | Barretos Cancer Hospital | 120 | 2022-06-27 | 2022-08-08 |
| Hypo Versus Conventional Fractionation in Reconstructed-Breast Cancer Mastectomy Patients Hypofractionation, Conventional Fractionation - Breast Cancer, Radiotherapy; Complications | Phase 3 | Not yet recruiting | Seoul National University Bundang Hospital | 622 | 2022-04-01 | 2022-03-11 |
| Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma Durvalumab, Hypofractionated Radiation Therapy, Tremelimumab - Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8 | Phase 2 | Recruiting | Mary Feng, MD | 21 | 2022-02-04 | 2025-12-08 |
| ADMIRAL Trial: Adaptive Mediastinal Radiation With Chemo-Immunotherapy Cisplatin, Durvalumab, Etoposide - Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 | Phase 2 | Terminated | University of Washington | 1 | 2021-12-10 | 2023-06-13 |
| Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer Carboplatin, Durvalumab, Paclitaxel - Locally Advanced Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 28 | 2021-12-06 | 2026-06-30 |
| Hypofractionated Radiotherapy for the Treatment of Cervical or Endometrial Cancer Hypofractionated Radiation Therapy - Cervical Carcinoma, Endometrial Carcinoma | Not applicable | Active not recruiting | University of Utah | 22 | 2021-11-11 | 2026-09-04 |
| Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial Hypofractionated Radiation Therapy, Questionnaire Administration, Magnetic Resonance Imaging - Diffuse Midline Glioma, H3 K27M-Mutant | Phase 2 | Active not recruiting | Mayo Clinic | 17 | 2021-10-11 | 2026-09-18 |
| Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma Bintrafusp Alfa, Biopsy, Hypofractionated Radiation Therapy - Locally Advanced Intrahepatic Cholangiocarcinoma, Metastatic Intrahepatic Cholangiocarcinoma | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 2 | 2021-08-31 | 2026-09-14 |
| Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus II Conventional Fractionation, Hypofractionation - Endometrial Cancer | Not applicable | Unknown | Sunnybrook Health Sciences Centre | 50 | 2021-07-15 | 2021-10-25 |
Showing 20 of 51. Sign in to see all of them.
Breast Neoplasms (11) · Prostatic Neoplasms (9) · Lung Neoplasms (4) · Carcinoma, Intraductal, Noninfiltrating (2) · Carcinoma, Non-Small-Cell Lung (2) · Cholangiocarcinoma (2) · Endometrial Neoplasms (2) · Lymphatic Metastasis (2) · Pancreatic Neoplasms (2) · Sarcoma (2) · Uterine Cervical Neoplasms (2) · Brain Neoplasms (1) · Breast Carcinoma In Situ (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Renal Cell (1)
Mayo Clinic (10) · M.D. Anderson Cancer Center (5) · University of Utah (4) · Jonsson Comprehensive Cancer Center (3) · National Cancer Institute (NCI) (3) · University Hospital, Ghent (3) · University of Washington (3) · Emory University (2) · NRG Oncology (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Academic and Community Cancer Research United (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Alexandria University (1) · Barretos Cancer Hospital (1) · Mary Feng, MD (1)
United States (38) · Canada (5) · Belgium (3) · Brazil (1) · Egypt (1) · India (1) · Netherlands (1) · Switzerland (1) · Uganda (1)
Carlos E. Vargas, M.D. (2) · Carlos E. Vargas, MD (2) · Jing Zeng (2) · Roman O. Kowalchuk, MD (2) · Adam Gladwish, MD (1) · Alejandro Sanchez (1) · Amar Kishan (1) · Anusa Kalbasi, MD (1) · Ashraf M El-Enbaby, Prof (1) · Benjamin D Smith (1) · Bree R Eaton (1) · Budhi S Yadav, MD (1) · Carlos Vargas (1) · Christopher L. Hallemeier, MD (1) · Curtland Deville, MD (1)
PMID 26247543, PMID 29485064, PMID 29485066, PMID 30027292, PMID 33428583, PMID 33577365, PMID 33992718, PMID 37224928, PMID 37696281, PMID 37914139, PMID 38483412, PMID 38578640, PMID 38745333, PMID 40314623, PMID 40366003, PMID 40389098, PMID 41405883
U10CA180868 (2), D43TW009759 (1), P30CA015083 (1), P30CA015704 (1), P30CA042014 (1), P30CA138292 (1), R01CA262388 (1), U10CA180888 (1), UM1CA186644 (1), UM1CA186691 (1), UM1CA186716 (1)