10 completed, 6 active not recruiting, 6 recruiting, 3 terminated. 29 Phase 2, 3 Phase 1.
Follow Hypofractionation: new trials by email Literature Review of Hypofractionation trials Research Report on Hypofractionation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypofractionated Definitive Chemoradiotherapy for Oesophageal Cancer Hypofractionation, carboplatin + paclitaxel (CP) - Locally Advanced Esophageal or GE Junction Cancer | Phase 2 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 60 | 2026-04-28 | 2026-06-08 |
| Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda Hypofractionated Radiation Therapy, Conventional Fractionated Radiotherapy, Cisplatin - Cervical Cancer, Cervix Cancer | Phase 2 | Recruiting | Uganda Cancer Institute | 278 | 2026-03-11 | 2026-03-27 |
| Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer Biopsy of Breast, Biospecimen Collection, Breast Surgery - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 120 | 2025-05-14 | 2026-09-03 |
| Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma Bevacizumab, Biospecimen Collection, Computed Tomography - Recurrent Glioblastoma, Recurrent WHO Grade 4 Glioma | Phase 2 | Recruiting | Academic and Community Cancer Research United | 134 | 2024-10-02 | 2024-11-19 |
| HYpofractionated Pelvic Radiotherapy for Advanced Cervical Cancers INeligible for ChemoTherapy Hypofractionation - Locally Advanced Cervical Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | University of Santo Tomas Hospital, Philippines | 55 | 2024-01-01 | 2023-01-31 |
| Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma Biospecimen Collection, Computed Tomography, Endoscopic Ultrasound - Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 99 | 2023-11-21 | 2026-10-01 |
| Hypofractionated Radiation Therapy After Durvalumab and Chemotherapy for the Treatment of Stage IV Extensive Stage Small Cell Lung Cancer, CASPIAN-RT Trial Carboplatin, Cisplatin, Durvalumab - Extensive Stage Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 2 | Withdrawn | University of Washington | 2023-10-19 | 2023-10-18 | |
| Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma Durvalumab, Hypofractionated Radiation Therapy, Tremelimumab - Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8 | Phase 2 | Recruiting | Mary Feng, MD | 21 | 2022-02-04 | 2025-12-08 |
| ADMIRAL Trial: Adaptive Mediastinal Radiation With Chemo-Immunotherapy Cisplatin, Durvalumab, Etoposide - Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 | Phase 2 | Terminated | University of Washington | 1 | 2021-12-10 | 2023-06-13 |
| Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial Hypofractionated Radiation Therapy, Questionnaire Administration, Magnetic Resonance Imaging - Diffuse Midline Glioma, H3 K27M-Mutant | Phase 2 | Active not recruiting | Mayo Clinic | 17 | 2021-10-11 | 2026-09-18 |
| NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer Hafnium Oxide-containing Nanoparticles NBTXR3, Hypofractionated Radiation Therapy, Pembrolizumab - Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 2 | Terminated | M.D. Anderson Cancer Center | 14 | 2021-04-07 | 2026-01-23 |
| Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients Atezolizumab, Biospecimen Collection, Computed Tomography - Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 47 | 2021-01-13 | 2026-08-24 |
| Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Suspended | National Cancer Institute (NCI) | 92 | 2021-01-11 | 2026-10-20 |
| Radiation Therapy Before Surgery for Localized, Resectable Soft Tissue Sarcoma of the Extremity and Superficial Trunk Hypofractionated Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration - Resectable Soft Tissue Sarcoma, Stage I Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Phase 2 | Active not recruiting | Mayo Clinic | 120 | 2020-11-30 | 2026-02-04 |
| Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies Avelumab, Biopsy Procedure, Biospecimen Collection - Locally Advanced Malignant Solid Neoplasm, Locally Advanced Unresectable Cholangiocarcinoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 103 | 2020-04-07 | 2026-10-02 |
| Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer Hypofractionated Radiation Therapy, Intensity-Modulated Radiation Therapy, Metastasectomy - Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Completed | University of Utah | 20 | 2019-09-09 | 2026-07-22 |
| Hypofractionated Radiation Therapy in Treating Participants With Breast Cancer Before Surgery Hypofractionated Radiation Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Phase 2 | Completed | Mayo Clinic | 25 | 2018-11-20 | 2026-05-15 |
| Radiation Therapy and Pembrolizumab in Treating Patients With Localized Urothelial Bladder Cancer Hypofractionated Radiation Therapy, Laboratory Biomarker Analysis, Pembrolizumab - Infiltrating Bladder Urothelial Carcinoma, Stage II Bladder Urothelial Carcinoma AJCC v6 and v7 | Phase 2 | Withdrawn | University of California, San Francisco | 2018-07-18 | 2018-12-07 | |
| Hypofractionated Radiation Therapy for Treating Prostate Cancer High-Risk Features Following Radical Prostatectomy Androgen Suppression, Hypofractionated Radiation Therapy, Quality-of-Life Assessment - Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8 | Phase 2 | Completed | Mayo Clinic | 53 | 2018-05-14 | 2026-05-26 |
| Hypofractionated Radiation Therapy in Treating Patients With Stage 0-IIB Breast Cancer Hypofractionated Radiation Therapy - Ductal Breast Carcinoma In Situ, Invasive Breast Carcinoma | Phase 2 | Completed | University of Utah | 102 | 2017-12-12 | 2025-12-30 |
Showing 20 of 29. Sign in to see all of them.
Breast Neoplasms (6) · Prostatic Neoplasms (5) · Lung Neoplasms (3) · Carcinoma, Intraductal, Noninfiltrating (2) · Carcinoma, Non-Small-Cell Lung (2) · Breast Carcinoma In Situ (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Renal Cell (1) · Cholangiocarcinoma (1) · Gallbladder Neoplasms (1) · Glioblastoma (1) · Lymphatic Metastasis (1) · Melanoma (1) · Neoplasm Metastasis (1) · Pancreatic Neoplasms (1)
Mayo Clinic (7) · M.D. Anderson Cancer Center (3) · National Cancer Institute (NCI) (3) · University of Washington (3) · University Hospital, Ghent (2) · University of Utah (2) · Academic and Community Cancer Research United (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Emory University (1) · Mary Feng, MD (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Uganda Cancer Institute (1) · University of California, San Francisco (1) · University of Santo Tomas Hospital, Philippines (1)
United States (23) · Belgium (2) · India (1) · Netherlands (1) · Uganda (1)
Carlos E. Vargas, M.D. (2) · Jing Zeng (2) · Alejandro Sanchez (1) · Benjamin D Smith (1) · Budhi S Yadav, MD (1) · Carlos E. Vargas, MD (1) · Christopher L. Hallemeier, MD (1) · Danny Song, MD (1) · Jay Reddy (1) · Jian L Campian (1) · Karen Hoffman, MD (1) · Kristen R Spencer (1) · Mary Feng, MD (1) · Matthew Poppe (1) · Peter S.N. van Rossum (1)
PMID 26247543, PMID 29485064, PMID 29485066, PMID 30027292, PMID 33428583, PMID 33992718, PMID 37696281, PMID 38578640, PMID 40314623, PMID 40366003, PMID 40389098
D43TW009759 (1), P30CA015083 (1), P30CA015704 (1), U10CA180888 (1), UM1CA186644 (1), UM1CA186691 (1), UM1CA186716 (1)