15 completed, 8 unknown, 6 recruiting, 5 active not recruiting. 14 Phase 2, 7 Phase 3, 7 Phase 4, 6 Not applicable, 2 Phase 1.
Follow GnRH agonist: new trials by email Literature Review of GnRH agonist trials Research Report on GnRH agonist
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Estrogen to Improve Quality of Life for Men With Newly Diagnosed or Recurrent Metastatic Hormone Sensitive Prostate Cancer, EQUIP Trial Androgen Receptor Pathway Inhibitor, Transdermal Estrogen, Bone Scan - Castration-Sensitive Prostate Adenocarcinoma, Metastatic Castration-Sensitive Prostate Adenocarcinoma | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 60 | 2026-11-01 | 2026-10-16 |
| BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder Aromatase Inhibitors, Bupropion, GnRH agonist - Early-stage Breast Cancer, Hypoactive Sexual Desire Disorder | Phase 1 / Phase 2 | Not yet recruiting | University of Illinois at Chicago | 100 | 2026-09-01 | 2026-08-24 |
| Effect of GnRH Agonist in FET GnRH agonist - GnRH Agonist | Phase 1 / Phase 2 | Not yet recruiting | Assiut University | 122 | 2026-08-01 | 2026-06-17 |
| GnRH for Luteal Support - Mechanism of Action GnRH agonist, Progesterone - GnRH Antagonist IVF Protocol, Fresh Embryo Transfer | Recruiting | Heli Alexandroni | 150 | 2026-05-18 | 2026-06-02 | |
| Dual Trigger With HCG and GnRH Agonist on Thawed Modified Natural Cycle Embryo Transfer GnRH agonist - In Vitro Fertilization (IVF), Embryo Transfer | Phase 4 | Not yet recruiting | National Taiwan University Hospital | 170 | 2026-01-01 | 2025-12-16 |
| Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer Abemaciclib, Anastrozole, Biospecimen Collection - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 2 | Recruiting | University of Washington | 60 | 2024-07-22 | 2026-09-24 |
| Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment of Prostate Cancer Abiraterone Acetate, Biospecimen Collection, Computed Tomography - Oligometastatic Prostate Carcinoma, Prostate Adenocarcinoma | Phase 2 | Active not recruiting | Mayo Clinic | 110 | 2024-04-22 | 2026-09-25 |
| Immunotherapy, Hormone Therapy, and AKT Inhibitor for Premenopausal ER Positive MBC Goserelin, Fulvestrant, Capivasertib - Premenopausal Breast Cancer, Metastatic Breast Cancer | Phase 2 | Recruiting | National Taiwan University Hospital | 42 | 2023-01-17 | 2024-06-10 |
| Two Different Types of Luteal Phase Support in Natural Cycle Frozen Embryo Transfer and Its Effect on Pregnancy Rates GnRH agonist, hCG, Progesterone 100Mg Vag Tab - Luteal Phase Support | Not applicable | Unknown | Shaare Zedek Medical Center | 144 | 2022-10-01 | 2023-05-01 |
| Benefit of GnRH Agonist Before Frozen Embryo Transfer in Patients With Endometriosis and/or Adenomyosis GnRH agonist - Endometriosis, Adenomyosis | Phase 2 / Phase 3 | Recruiting | Hopital Foch | 180 | 2021-03-18 | 2026-01-16 |
| Skeletal Health and Bone Marrow Composition Among Youth GnRH Agonist - Gender Dysphoria in Children, Puberty | Not applicable | Terminated | Amy DiVasta, MD | 78 | 2020-09-15 | 2026-04-03 |
| GnRH Agonist for Luteal Phase Support. GnRH agonist, Progesterone - Use of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles | Not applicable | Unknown | Shaare Zedek Medical Center | 150 | 2020-06-08 | 2022-08-02 |
| INTREPId (INTermediate Risk Erection PreservatIon Trial) Bicalutamide, GnRH Agonist, Radiation Therapy - Prostate Cancer | Phase 2 | Active not recruiting | Brigham and Women's Hospital | 234 | 2020-06-01 | 2025-12-15 |
| A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma Apalutamide, GnRH Agonist - Salivary Gland Neoplasms | Phase 2 | Active not recruiting | Janssen Pharmaceutical K.K. | 31 | 2020-04-07 | 2026-09-25 |
| Cardiovascular Events in GnRH Agonist vs. Antagonist Degarelix, GnRH agonist - Hormone Sensitive Prostate Cancer, Prostate Cancer | Phase 2 | Unknown | Rabin Medical Center | 80 | 2020-01-17 | 2019-12-02 |
| Intramuscular Mechanisms of Androgen Deprivation-related Sarcopenia GnRH agonist - Metastatic Prostate Cancer, Androgen Deprivation Therapy | Completed | Seattle Institute for Biomedical and Clinical Research | 60 | 2018-12-07 | 2024-09-04 | |
| Intermittent Androgen Deprivation Therapy for Stage IV Castration Sensitive Prostate Cancer Adaptive Androgen Deprivation Therapy (ADT), Abiraterone, Prednisone - Prostate Cancer, Stage IV Prostate Cancer | Early Phase 1 | Active not recruiting | H. Lee Moffitt Cancer Center and Research Institute | 17 | 2018-09-17 | 2025-12-04 |
| Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC Progesterone, Mirena®, GnRH agonist - Endometrial Cancer, Atypical Endometrial Hyperplasia | Phase 2 / Phase 3 | Recruiting | West China Second University Hospital | 224 | 2018-04-01 | 2021-09-13 |
| Apalutamide and Gonadotropin-Releasing Hormone Analog With or Without Abiraterone Acetate in Treating Participants With Prostate Cancer Abiraterone Acetate, Apalutamide, Gonadotropin-releasing Hormone Analog - Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8 | Phase 2 | Completed | M.D. Anderson Cancer Center | 86 | 2017-10-13 | 2022-08-10 |
| Value of Cabergoline and Low Dose Aspirin in Poor Responders Undergoing ICSI-ET With GnRH Agonist Flare-Up-Protocol cabergoline, Aspirin, GnRH agonist - Invitro Fertilization | Phase 4 | Unknown | Cairo University | 120 | 2017-08-01 | 2017-08-28 |
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Prostatic Neoplasms (8) · Infertility (6) · Breast Neoplasms (3) · Puberty, Precocious (2) · Adenomyosis (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Disease Susceptibility (1) · Endometrial Hyperplasia (1) · Endometrial Neoplasms (1) · Endometriosis (1) · Helping Behavior (1) · Infertility, Female (1) · Metabolic Syndrome (1) · Neoplasm Metastasis (1)
Cairo University (4) · National Taiwan University Hospital (2) · Shaare Zedek Medical Center (2) · Alliance for Clinical Trials in Oncology (1) · Amy DiVasta, MD (1) · Assiut University (1) · Brigham and Women's Hospital (1) · Centro Ginecologia y Obstetricia. (1) · Fred Hutchinson Cancer Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Heli Alexandroni (1) · Hopital Foch (1) · Huang Rui (1) · Instituto Bernabeu (1) · Istituto Clinico Humanitas (1)
United States (15) · Egypt (4) · Israel (4) · China (3) · Canada (2) · Spain (2) · Belgium (1) · Brazil (1) · Denmark (1) · France (1) · Japan (1) · South Korea (1) · Taiwan (1)
Ahmed Maged, MD (1) · Carlos E. Vargas, M.D. (1) · Christopher Logothetis (1) · David Margel, MD, PhD (1) · Eman K Shaeer, MD (1) · Esben T. Vestergaard, MD PhD (1) · Hannah Linden (1) · Jingsong Zhang, M.D., Ph.D. (1) · Jose M Garcia, MD, PhD (1) · Juan C Castillo, Md. PhD. (1) · Keren Rotshenker Olshnika, MD (1) · Kostas Kamperis, MD PhD (1) · Kurt Kristensen, MD PhD (1)
PMID 20378616, PMID 21450755, PMID 24590644, PMID 25069504, PMID 25724740, PMID 29996682, PMID 30500132, PMID 31668850, PMID 32909630, PMID 33011968, PMID 33150745, PMID 33270906, PMID 34350976, PMID 35153154, PMID 36358643, PMID 36918869, PMID 37186265, PMID 37361538, PMID 39978378, PMID 41202201
P30CA072720 (1), P50HD073063 (1), U10CA031946 (1)