12 completed, 2 recruiting, 1 terminated, 1 withdrawn. 10 Not applicable, 4 Phase 1, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 8, Recruiting 1, Terminated 1 |
| Phase 1 | 4 | Completed 4 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 4 | 1 | Withdrawn 1 |
Follow Glucose clamp: new trials by email Literature Review of Glucose clamp trials Research Report on Glucose clamp
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Glucose-Independent Effects of Exogenous Glucagon on Insulin Secretion and Cognitive Function in Healthy Subjects Glucagon Infusion, Glucose clamp - Glucose Metabolism, Insulin Secretion | Not applicable | Completed | Nicolai Jacob Wewer Albrechtsen | 15 | 2024-11-08 | 2026-04-29 |
| Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise Muscle Biopsy, Adipose Biopsy, Glucose Clamp - Obesity | Not applicable | Recruiting | AdventHealth Translational Research Institute | 70 | 2024-09-11 | 2026-03-27 |
| Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion Somatostatin, Dextrose, Insulin - Healthy | Phase 4 | Withdrawn | Mayo Clinic | 2020-02-01 | 2022-09-09 | |
| Effect of Glucose on QTc Interval in Type 1 Diabetes Moxifloxacin, hyper-glycaemic clamp - Diabetes | Phase 1 | Completed | Richmond Research Institute | 24 | 2019-02-10 | 2021-05-05 |
| Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2) Hyperinsulinemic, euglycemic clamp, 20% dextrose - Type 1 Diabetes Mellitus, Maturity-Onset Diabetes of the Young, Type 2 | Phase 1 | Completed | Vanderbilt University | 33 | 2016-12-01 | 2019-08-01 |
| Differing Levels of Hypoglycemia Glucose clamp - Hypoglycemia | Early Phase 1 | Recruiting | University of Maryland, Baltimore | 32 | 2015-07-01 | 2025-11-10 |
| Metabolomic Analysis of Hepatic Insulin Resistance Hyperinsulinemic-euglycemic clamp - Type 2 Diabetes, Obesity | Not applicable | Completed | University of Minnesota | 4 | 2013-04-01 | 2017-04-20 |
| A Trial Investigating the Effect of Acute Hypoglycaemia on Cognitive Function and Brain Activation Patterns in Subjects With Type 1 Diabetes glucose clamp - Diabetes, Diabetes Mellitus, Type 1 | Phase 1 | Completed | Novo Nordisk A/S | 29 | 2013-01-14 | 2018-01-12 |
| A Trial to Investigate the Impact of Nocturnal Hypoglycaemia on Sleep in Subjects With Type 2 Diabetes glucose clamp - Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | Novo Nordisk A/S | 26 | 2013-01-01 | 2017-01-23 |
| Type 1 Diabetes and Depression: Role of Brain Glutamate Glucose Clamp - Type1diabetes, Depressive Symptoms | Not applicable | Completed | Beth Israel Deaconess Medical Center | 68 | 2011-01-01 | 2022-05-05 |
| Hepatic Insulin Sensitivity and Very Low Density Lipoprotein Triglyceride (VLDL-TG) Kinetics Glucose clamp - Obesity, Dyslipidemia | Not applicable | Completed | University of Aarhus | 24 | 2010-03-01 | 2011-06-17 |
| The Aim is to Estimate the Total Amount of Insulin-producing Cells in the Pancreas by MRI. MR imaging, Glucose clamp, Arginine - Diabetes Mellitus | Not applicable | Terminated | Pfizer | 29 | 2005-12-01 | 2009-08-07 |
| Glimepiride Induced Insulin Secretion Will be Inhibited by Hypoglycemia Glimepiride, glyburide, glucose clamp - Type 2 Diabetes | Not applicable | Completed | Vanderbilt University | 32 | 2002-08-01 | 2014-12-11 |
| Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q.3 glucose clamp - Type 1 Diabetes | Not applicable | Completed | Vanderbilt University | 22 | 2001-03-01 | 2015-06-10 |
| Metabolic Adaptations to Diabetes in African Americans glucose clamp - Diabetes | Not applicable | Completed | Vanderbilt University | 16 | 1998-07-01 | 2014-12-11 |
| Metabolic Adaptation to Diabetes glucose clamp - Type 2 Diabetes | Not applicable | Completed | Vanderbilt University | 15 | 1998-02-01 | 2014-12-11 |
Diabetes Mellitus (5) · Diabetes Mellitus, Type 2 (4) · Diabetes Mellitus, Type 1 (3) · Obesity (3) · Hyperglycemia (2) · Hypoglycemia (2) · Depression (1) · Depressive Disorder, Major (1) · Dyslipidemias (1) · Insulin Resistance (1) · Maturity-Onset Diabetes of the Young, Type 2 (1)
Vanderbilt University (5) · Novo Nordisk A/S (2) · AdventHealth Translational Research Institute (1) · Beth Israel Deaconess Medical Center (1) · Mayo Clinic (1) · Nicolai Jacob Wewer Albrechtsen (1) · Pfizer (1) · Richmond Research Institute (1) · University of Aarhus (1) · University of Maryland, Baltimore (1) · University of Minnesota (1)
United States (7) · Denmark (4) · United Kingdom (1)
Stephen N Davis, MD (2) · Stephen N. Davis, MD (2) · Adrian Vella, MD (1) · Jorg Taubel, MD FFPM (1) · Justin M Gregory, MD (1) · Lauren Sparks, PhD (1) · Lisa Chow, MD (1) · Nicolai J Wewer Albrecthsen, MD PhD (1) · Nicolas R Bolo, PhD (1) · Ursula White, PhD (1)
PMID 19488737, PMID 26407587, PMID 29188338, PMID 31092478, PMID 32295804, PMID 35417272, PMID 35596784
R01DK078646 (1)