A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste

• 0.454% stannous fluoride (Drug): fluoride toothpaste
• 0.76% sodium monofluorophosphate (Drug): regular fluoride toothpaste

Primary outcomes

• Mean Organoleptic scores for each treatment group [Baseline, 12 hours post brushing and 3 weeks]: For each subject at each evaluation time point, the hedonic breath-odor scores assigned by the four (4) judges were averaged to yield a single subject-wise score. Statistical analyses were performed on these average organoleptic hedonic scores.

Sex: All, ages: 18 Years to 70 Years, accepts healthy volunteers

Inclusion Criteria:

* Male and female adults between the ages of 18-70 (inclusive)
* Subjects must be in general good health
* Subjects must be in good oral health based on self-assessment
* Subjects must be available for the duration of the study for all time point assessments
* Subjects were required to possess a minimum of 20 natural uncrowned teeth (excluding third molars)
* Subjects were required to sign an Informed Consent form
* No known history or allergies to personal care/consumer products or their ingredients.

Exclusion Criteria:

* Participated in any other oral clinical studies during the duration of this study
* Had full or partial (upper or lower) dentures
* Women who are pregnant or lactating (breast feeding)
* Use of tobacco products, (5) History of allergies to common mouthwash ingredients
* Use of phenolic flavored products, such as mint flavored candies and chewing gum the morning of the study of during the sampling periods
* Immune compromised individuals (HIV, AIDS, immune suppressive drug therapy
* Individuals who, due to medical conditions cannot go without eating or drinking for the post use treatment evaluation time points (6-hours plus overnight).

• Terdphong Triratana, DDS, Principal investigator, Mahidol University