Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.

• 0.454% stannous fluoride (Drug): brushed twice daily, morning and evening for 2 minutes eact time
• 0.76% sodium monofluorophosphate (Drug): brushed twice daily, morning and evening for 2 minutes eact time

Primary outcomes

• Supragingival calculus formation via Volpe-Manhold Calculus Index [baseline and 12 week measurement]: index for comparing the amount of dental calculus

Sex: All, ages: 18 Years to 70 Years, accepts healthy volunteers

Inclusion Criteria:

* Subjects were required to sign an Informed Consent form
* Subjects had to be in general good health
* Male and female adults between the ages of 18-70 (inclusive)
* Six (6) scoreable mandibular anterior teeth free of large restorations or dental prosthetic crowns
* Subjects were required to possess a Volpe-Manhold Calculus Index of at least 7.0
* Subjects had to be able to participate for the full duration (20 weeks) of the study

Exclusion Criteria:

* Presence of orthodontic appliances or removable prosthesis at the lower jaw or more than one mandibular anterior tooth with a prosthetic crown or veneer
* Tumor(s) or significant pathology of the soft or hard tissues of the oral cavity
* Moderate or advanced periodontal disease
* Five or more carious lesions requiring immediate care
* Use of antibiotics or steroids any time during one month prior to entry into the study
* Participation in any other clinical study or panel test
* Pregnant or breast feeding women
* History of allergies to dentifrice and personal care ingredients
* Allergies to dentifrice products
* Medical reasons that prohibit eating or drinking for 4 hours prior to clinical facility visit.

• Dutmanee Seriwatanachai, Principal investigator, Mahidol University