28 completed, 12 unknown, 4 not yet recruiting, 3 recruiting. 25 Not applicable, 10 Phase 3, 7 Phase 2, 3 Early Phase 1, 2 Phase 4.
Follow Fluoride varnish: new trials by email Literature Review of Fluoride varnish trials Research Report on Fluoride varnish
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Bioactive Glass Varnish on Salivary Parameters in Children: Randomized Controlled Trial Bioactive glass topical varnish, Fluoride varnish - Prevention of Dental Caries | Not applicable | Not yet recruiting | Pharos University in Alexandria | 30 | 2026-11-01 | 2026-10-15 |
| The Effectiveness of the Self-Assembling Peptide P11-4 in the Remineralization of Enamel Carious White Spot Lesions Self-assembling peptide P11-4, Fluoride varnish - White Spot Lesions on Smooth Surface of Tooth | Not applicable | Recruiting | Medical University of Warsaw | 75 | 2026-02-02 | 2026-06-23 |
| Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients. Fluoride varnish, Novel titania nanoparticle infused fluoride varnish - Dental Plaque Accumulation, Nanoparticles | Not applicable | Recruiting | Pakistan Institute of Medical Sciences | 20 | 2025-11-01 | 2025-09-25 |
| Comparative Efficacy of Laser Systems and Fluoride in Managing Dentinal Hypersensitivity: RCT Erbium laser (2940 nm): Infrared light energy, Diode laser (650 nm): Visible red light energy, Fluoride varnish - Dentin Sensitivity, Dentine Hypersensitivity, Tooth Sensitivity | Not applicable | Not yet recruiting | Cairo University | 96 | 2025-09-01 | 2025-08-26 |
| Comparison of the Efficacy of Three Preventive Methods to Reduce the Incidence of Coronal Caries in Schoolchildren Glass ionomer pit and fissure sealant plus fluoride varnish, Pit and fissure sealant with Giomer® technology, Fluoride varnish - Caries Prevention | Not applicable | Recruiting | Universidad Nacional Autonoma de Mexico | 204 | 2025-09-01 | 2025-09-24 |
| Remineralization Effect Of Egg Shell Versus Fluoride Varnish On Early Carious White Spot Lesions In Primary Teeth Egg shell hydrogel, Fluoride varnish - White Spot Lesion | Phase 2 | Not yet recruiting | Cairo University | 66 | 2025-09-01 | 2025-05-15 |
| Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious Lesions Gluma Desensitizer, Bioactive glass, Fluoride varnish - Dentin Hypersensitivity | Not applicable | Completed | British University In Egypt | 40 | 2025-02-03 | 2026-02-06 |
| Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents in Teeth With MIH Giomer varnish, Fluoride varnish - Molar Incisor Hypomineralization | Phase 3 | Unknown | Cairo University | 24 | 2025-02-01 | 2023-09-01 |
| Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline - Demineralization, Tooth, White Spot Lesion of Tooth | Phase 2 | Not yet recruiting | National University of Malaysia | 99 | 2025-01-31 | 2025-01-30 |
| Root Caries Prevention Using Fluoride Varnish Fortified With SBGC Fluoride varnish with SBGC, Fluoride varnish - Dental Caries of Root Surface, Root Caries | Not applicable | Active not recruiting | The University of Hong Kong | 540 | 2024-01-15 | 2026-04-29 |
| Effects of Topical Fluoride in Orthodontic Patients Fluoride gel, Fluoride varnish - Topical Fluoride, Orthodontic Patients | Not applicable | Active not recruiting | Universita di Verona | 60 | 2023-11-16 | 2025-07-29 |
| "Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children." Fluoride Varnish - Dental Caries, Tooth Demineralization | Not applicable | Completed | Sacide Duman | 26 | 2023-10-04 | 2026-03-27 |
| Early Treatments for Preventing Occlusal Caries Lesions Fluoride varnish, Conventional etch and rinse sealant, Self-etch sealant - Caries; Initial, Occlusal Caries | Not applicable | Completed | Hue University of Medicine and Pharmacy | 132 | 2023-07-31 | 2026-05-14 |
| Randomized Clinical Trial: Oral Health Package Law and Fluor Varnish Impact on Schoolchildren in Merida, Mexico Fluoride varnish, Fluoride toothpaste - Caries, Gum Disease | Phase 3 | Unknown | Anahuac Mayab University | 900 | 2023-06-22 | 2023-07-25 |
| Efficacy and Safety Evaluation of Anti-Caries Varnish Test varnish, Placebo - Dental Caries in Children | Phase 2 | Completed | Advantage Silver Dental Arrest, LLC | 274 | 2022-06-04 | 2025-10-09 |
| Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions Remin Pro, X Pur Remin, Fluoride varnish - White Spot Lesion of Tooth | Not applicable | Completed | Al-Azhar University | 45 | 2022-05-05 | 2023-05-24 |
| Intensive Preventative Dental Program Pilot Study Fluoride varnish, Regular Care, Medical Oncology Care Team - Dental Diseases | Early Phase 1 | Completed | Wake Forest University Health Sciences | 13 | 2021-10-19 | 2025-11-03 |
| Prevention of Spontaneous Dental Abscesses in Children With X-linked Hypophosphatemia : a RCT adhesive system, fluoride varnish, flowable composite - X-linked Hypophosphatemia (XLH) | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 60 | 2021-06-01 | 2021-05-05 |
| Efficacy of Desensitizing Agent,Propolis After an In-office Vital Tooth Bleaching. Propolis, hydrogen peroxide 35%, fluoride varnish - Post Operative Pain | Not applicable | Completed | Dow University of Health Sciences | 90 | 2021-05-14 | 2022-10-06 |
| Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients PRG Barrier Coat, Fluoride varnish, MI paste - White Spot Lesions [Initial Caries] on Smooth Surface of Tooth | Phase 1 | Unknown | Ain Shams University | 60 | 2021-01-01 | 2022-01-24 |
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Dental Caries (19) · Dentin Sensitivity (5) · Tooth Demineralization (4) · Hypersensitivity (3) · Molar Hypomineralization (2) · Familial Hypophosphatemic Rickets (1) · Gingival Diseases (1) · Head and Neck Neoplasms (1) · Infections (1) · Mucositis (1) · Osteoradionecrosis (1) · Pain, Postoperative (1) · Paresthesia (1) · Personal Satisfaction (1) · Root Caries (1)
Cairo University (5) · The University of Hong Kong (3) · University of California, San Francisco (3) · University of Washington (3) · Medical University of Warsaw (2) · University of Sao Paulo (2) · Advantage Silver Dental Arrest, LLC (1) · Ain Shams University (1) · Al-Azhar University (1) · Anahuac Mayab University (1) · Arwa Owais (1) · Assistance Publique - Hôpitaux de Paris (1) · Azad University of Medical Sciences (1) · British University In Egypt (1) · CareQuest Institute for Oral Health (1)
United States (13) · Egypt (5) · Brazil (2) · China (2) · Hong Kong (2) · Mexico (2) · Pakistan (2) · Poland (2) · Canada (1) · Iran (1) · Italy (1) · Malaysia (1) · Saudi Arabia (1) · Thailand (1) · Turkey (Türkiye) (1)
Abdulrahman J Alhaddad, DScD (1) · Abeer Abd Elatiif, professor (1) · Ahmad Shuhud Irfani Zakaria, MClinDent (1) · Amr Abd El Aziz, Professor (1) · Arwa I Owais, BDS, MS (1) · Cynthia KY Yiu, MDS, PhD (1) · Dafina Doberdoli, Dr. (1) · Dorota Olczak-Kowalczyk, Ass. Prof. (1) · Dorota Olczak-Kowalczyk, Ass.Prof. (1) · Dorota Olczak-Kowalczyk, Prof. (1) · Edward CM Lo, PhD (1) · Fatima Soomro, MDS (1) · Francisco J Ramos-Gomez, DDS,MS, MPH (1) · Francisco Ramos-Gomez, DDS, MPH (1)
PMID 25101490, PMID 28526003, PMID 11455374, PMID 15562583, PMID 1590288, PMID 16434737, PMID 17555173, PMID 17693365, PMID 17827963, PMID 18422711, PMID 18697848, PMID 20016179, PMID 20691346, PMID 20691360, PMID 20739697, PMID 21208070, PMID 21709814, PMID 21999806, PMID 22257664, PMID 22381494, PMID 22461872, PMID 22736448, PMID 24311016, PMID 24356441, PMID 24954053, PMID 24961881, PMID 25005885, PMID 25232515, PMID 25705704, PMID 26346538, PMID 26492796, PMID 27439724, PMID 27759164, PMID 27907894, PMID 28207379, PMID 28580541, PMID 28955548, PMID 29506010, PMID 31197364, PMID 31217917, PMID 3164585, PMID 31690590, PMID 31936256, PMID 32071698, PMID 32144336, PMID 32337230, PMID 33009565, PMID 33057826, PMID 33214593, PMID 33348756
R01DE014403 (1), U54DE019259 (1), U54DE019285 (1)