5 unknown, 3 terminated, 2 completed, 2 recruiting. 12 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Unknown 5, Terminated 3, Completed 2, Recruiting 2 |
| Phase 2 | 2 | Unknown 2 |
Follow Floxuridine: new trials by email Literature Review of Floxuridine trials Research Report on Floxuridine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion Pump Therapy With Systemic Therapy Intra arterial infusion Floxuridine (FUDR) combined with systemic therapy, Hepatic arterial infusion pump (HAIP), Systemic therapy (standard of care) - Colorectal Neoplasms, Floxuridine | Phase 3 | Recruiting | The Netherlands Cancer Institute | 306 | 2024-11-21 | 2025-03-04 |
| Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial Bevacizumab, Capecitabine, Cetuximab - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 408 | 2024-04-10 | 2026-09-24 |
| FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM Irinotecan, Oxaliplatin HAI, Floxuridine - Metastatic Colorectal Cancer, Liver Metastases | Phase 3 | Terminated | Sun Yat-sen University | 92 | 2021-12-31 | 2023-02-16 |
| Hepatic Arterial Infusion Pump Chemotherapy Combined With Systemic Chemotherapy (PUMP-IT) Floxuridine, Tricumed IP2000V infusion pump - Colorectal Neoplasms | Phase 2 / Phase 3 | Unknown | The Netherlands Cancer Institute | 31 | 2020-09-09 | 2020-09-17 |
| Adjuvant Systemic Chemotherapy With or Without HAI-FUDR in Patients With Resected CRLM FUDR, Oxaliplatin, Leucovorin - Colorectal Cancer, Liver Metastases | Phase 3 | Terminated | Sun Yat-sen University | 92 | 2018-05-28 | 2024-01-22 |
| Alternating Systemic and Hepatic Artery Infusion Therapy As Adjuvant Treatment After Resection of Liver Metastases From Colorectal Cancer Floxuridine (FUDR),Dexamethasone (DXM), Heparin in combination with Oxaliplatin and Capecitabine (CapeOX) or in combination with Oxaliplatin and Leucovorin and 5-FU (mFOLFOX6), Oxaliplatin and Capecitabine (CapeOX) or Oxaliplatin and Leucovorin and 5-FU (mFOLFOX6) - Resected Liver Metastases From Colorectal Cancer | Phase 2 / Phase 3 | Unknown | Ye Xu | 432 | 2015-09-01 | 2015-08-20 |
| A Multi-center Randomized Controlled Trial of Intraportal Chemotherapy Combined With Adjuvant Chemotherapy (mFOLFOX6) for Stage II and III Colon Cancer FUDR +oxaliplatin, oxaliplatin+Leucovorin+5-FU - Colorectal Cancer, Metastasis | Phase 3 | Unknown | Xu jianmin | 700 | 2015-02-01 | 2015-03-31 |
| A Study of Systemic Chemotherapy With/Without HAI in Patients With Initially Unresectable Colorectal Liver Metastasis mFOLFOX6, HAI - Metastatic Colorectal Cancer | Phase 3 | Unknown | Yuhong Li | 142 | 2014-03-01 | 2024-03-04 |
| Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer Preoperative hepatic and regional arterial chemotherapy using oxaliplatin, MMC and FUDR, surgery - Colorectal Neoplasms | Phase 3 | Unknown | Fudan University | 600 | 2008-12-01 | 2009-03-25 |
| Oxaliplatin and Capecitabine With or Without an Hepatic Arterial Infusion With Floxuridine in Treating Patients Who Are Undergoing Surgery and/or Ablation for Liver Metastases Due to Colorectal Cancer capecitabine, floxuridine, oxaliplatin - Colorectal Cancer, Metastatic Cancer | Phase 3 | Terminated | NSABP Foundation Inc | 22 | 2006-01-01 | 2013-05-15 |
| Chemotherapy With or Without Isolated Hepatic Perfusion With Melphalan in Treating Patients With Colorectal Cancer That Has Spread to the Liver FOLFIRI regimen, floxuridine, fluorouracil - Colorectal Cancer, Metastatic Cancer | Phase 3 | Completed | National Institutes of Health Clinical Center (CC) | 2001-03-01 | 2012-03-08 | |
| Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer dexamethasone, floxuridine, fluorouracil - Colorectal Cancer, Metastatic Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 135 | 1996-01-01 | 2016-07-13 |
Colorectal Neoplasms (11) · Neoplasm Metastasis (5) · Colonic Neoplasms (3) · Rectal Neoplasms (3)
Sun Yat-sen University (2) · The Netherlands Cancer Institute (2) · Alliance for Clinical Trials in Oncology (1) · ECOG-ACRIN Cancer Research Group (1) · Fudan University (1) · NSABP Foundation Inc (1) · National Institutes of Health Clinical Center (CC) (1) · Xu jianmin (1) · Ye Xu (1) · Yuhong Li (1)
China (6) · United States (4) · Netherlands (2) · Australia (1) · Peru (1) · Puerto Rico (1)
H. Richard Alexander, MD, FACS (1) · Hong Jiang, MD (1) · Koert FD Kuhlmann, MD, PhD (1) · Michael Lidsky (1) · Nancy E. Kemeny, MD (1) · Norman Wolmark, MD (1) · Ye Xu, Dr. (1) · Yu-hong Li, MD, Ph D (1) · Yuhong Li, MD (1)
PMID 11913730, PMID 12782596, PMID 16505413, PMID 33214446, PMID 38608150, PMID 39644535, PMID 42143303
2019 (1), 2023 (1), U10CA012027 (1), U10CA031946 (1), U10CA180820 (1)