15 completed, 5 terminated, 1 suspended, 1 unknown. 22 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 22 | Completed 15, Terminated 5, Suspended 1, Unknown 1 |
| Phase 1 | 2 | Terminated 2 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Examine the Effects of Oral Fenretinide ISLA101, Dengue 1 Live Virus Human Challenge (DENV-1-LVHC), Placebo - Dengue | Phase 2 | Completed | Island Pharmaceuticals | 15 | 2024-09-05 | 2025-10-24 |
| Study of LAU-7b for the Treatment of Long COVID in Adults LAU-7b for 3 cycles, LAU-7b for 1 cycle, then placebo, Placebo for 3 cycles - Long COVID | Phase 2 / Phase 3 | Completed | Laurent Pharmaceuticals Inc. | 272 | 2023-11-15 | 2026-01-06 |
| Study of LAU-7b for the Treatment of Coronavirus Disease 2019 (COVID-19) Disease in Adults LAU-7b, Placebo oral capsule - COVID-19 Disease | Phase 2 / Phase 3 | Terminated | Laurent Pharmaceuticals Inc. | 351 | 2020-08-18 | 2025-11-13 |
| Study of LAU-7b in the Treatment of Cystic Fibrosis in Adults LAU-7b, Placebo oral capsule - Cystic Fibrosis | Phase 2 | Completed | Laurent Pharmaceuticals Inc. | 166 | 2018-11-05 | 2024-10-09 |
| Trial of Intravenous Fenretinide Emulsion for Patients With Relapsed/Refractory Peripheral T-cell Lymphomas Fenretinide - Peripheral T-cell Lymphoma | Phase 2 | Unknown | CerRx, Inc. | 140 | 2016-12-01 | 2019-07-23 |
| Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer Fenretinide/LXS + Ketoconazole - Ovarian Cancer, Cancer of Ovary | Phase 1 / Phase 2 | Terminated | South Plains Oncology Consortium | 12 | 2012-02-01 | 2020-08-27 |
| A Randomized, Double-blind Study of the Effects of Fenretinide Administered in Subjects With Obesity Fenretinide, Placebo - Obesity, Insulin Resistance | Phase 2 | Suspended | University of California, San Diego | 21 | 2007-12-01 | 2021-02-10 |
| Study of Fenretinide in the Treatment of Geographic Atrophy Associated With Dry Age-Related Macular Degeneration Fenretinide - Geographic Atrophy, Dry Age Related Macular Degeneration | Phase 2 | Completed | Sirion Therapeutics, Inc. | 245 | 2006-12-01 | 2010-06-22 |
| Fenretinide and Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma fenretinide, rituximab - Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma, B-cell Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 32 | 2005-10-01 | 2014-10-06 |
| Fenretinide in Treating Patients With Biochemically Recurrent Hormone-Naïve Prostate Cancer fenretinide, laboratory biomarker analysis - Adenocarcinoma of the Prostate, Recurrent Prostate Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 23 | 2004-06-01 | 2015-03-06 |
| Neoadjuvant and Adjuvant Fenretinide Compared With Adjuvant Fenretinide Alone in Treating Patients Who Are Undergoing Surgical Resection For Recurrent Glioblastoma Multiforme fenretinide, therapeutic conventional surgery, pharmacological study - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 42 | 2003-12-01 | 2013-01-24 |
| Fenretinide In Treating Patients With Advanced or Metastatic Hormone-Refractory Prostate Cancer fenretinide - Prostate Cancer | Phase 2 | Completed | Cancer Therapeutics Research Group | 50 | 2003-11-01 | 2013-05-15 |
| Fenretinide in Treating Children With Recurrent or Resistant Neuroblastoma fenretinide, pharmacological study - Recurrent Neuroblastoma | Phase 2 | Completed | National Cancer Institute (NCI) | 70 | 2003-05-01 | 2013-10-08 |
| Fenretinide in Treating Patients With Recurrent or Metastatic Ovarian Epithelial or Primary Peritoneal Cancer fenretinide, laboratory biomarker analysis, pharmacological study - Recurrent Ovarian Epithelial Cancer, Recurrent Primary Peritoneal Cavity Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 40 | 2001-09-01 | 2013-03-25 |
| Chemotherapy in Treating Patients With Advanced Kidney Cancer fenretinide - Kidney Cancer | Phase 2 | Completed | Barbara Ann Karmanos Cancer Institute | 2000-12-01 | 2013-04-05 | |
| Fenretinide in Treating Patients With Recurrent Small Cell Lung Cancer fenretinide - Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 32 | 2000-11-01 | 2013-02-11 |
| Fenretinide in Treating Patients With Recurrent Malignant Glioma fenretinide - Brain and Central Nervous System Tumors | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2000-09-25 | 2018-06-27 | |
| Fenretinide in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Fenretinide - Head and Neck Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 11 | 2000-09-01 | 2018-11-01 |
| Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus Syndrome fenretinide, tretinoin - Melanoma (Skin) | Phase 2 | Completed | Eastern Cooperative Oncology Group | 38 | 1999-02-23 | 2023-06-18 |
| SWOG-9507, Fenretinide in Treating Patients With Neoplasia of the Mouth fenretinide - Head and Neck Cancer | Phase 2 | Terminated | SWOG Cancer Research Network | 5 | 1997-12-01 | 2012-07-24 |
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Head and Neck Neoplasms (3) · Brain Neoplasms (2) · Inflammation (2) · Mouth Neoplasms (2) · Prostatic Neoplasms (2) · Astrocytoma (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · COVID-19 (1) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Renal Cell (1) · Central Nervous System Neoplasms (1) · Cystic Fibrosis (1) · Dengue (1) · Geographic Atrophy (1)
National Cancer Institute (NCI) (6) · Laurent Pharmaceuticals Inc. (3) · M.D. Anderson Cancer Center (2) · Barbara Ann Karmanos Cancer Institute (1) · Cancer Therapeutics Research Group (1) · CerRx, Inc. (1) · Eastern Cooperative Oncology Group (1) · Island Pharmaceuticals (1) · SWOG Cancer Research Network (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Sirion Therapeutics, Inc. (1) · South Plains Oncology Consortium (1) · University of Alabama at Birmingham (1) · University of California, San Diego (1)
United States (19) · Canada (3) · Australia (2) · Hong Kong (1) · Singapore (1)
Jean-Marie Houle, PhD (2) · Agustin Garcia (1) · Ajay Gopal (1) · Barry J Maurer, MD, PhD (1) · Bert Slade, MD (1) · Bonnie S. Glisson, MD (1) · Gregory P. Kalemkerian, MD (1) · Jacek Pinski, MD (1) · Jayanthi Lea, MD (1) · Judith Villablanca (1) · Kerry M. Barnhart, Ph.D. (1) · Larry C Lands, MD PhD (1) · Lynn Mara Schuchter, MD (1) · Mario Chojkier, M.D. (1) · Michael Boyer (1)
PMID 15514370, PMID 15744595, PMID 20082080, PMID 28420721, PMID 33331670
P30CA016672 (2), N01CM17101 (1), N01CM62209 (1), P30CA022453 (1), R21CA097767 (1), R21CA119519 (1), U01CA062487 (1), U01CA070172 (1), U10CA037429 (1), U10CA098543 (1)