49 completed, 23 terminated, 20 active not recruiting, 20 recruiting. 64 Phase 2, 33 Phase 1, 20 Not applicable, 19 Phase 3, 3 Early Phase 1.
Follow External Beam Radiation Therapy: new trials by email Literature Review of External Beam Radiation Therapy trials Research Report on External Beam Radiation Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Radiotherapy 12Gy in 6 Fractions For Orbital Lymphoma External Beam Radiation Therapy - Orbital Lymphoma | Not applicable | Not yet recruiting | British Columbia Cancer Agency | 36 | 2026-12-01 | 2026-10-13 |
| Adding Spatially Fractionated Radiation Therapy to Standard Palliative Radiation for Improving Disease-Related Symptoms in Patients With Unresectable Solid Tumors Electronic Health Record Review, External Beam Radiation Therapy, Questionnaire Administration - Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm | Not applicable | Recruiting | Mayo Clinic | 100 | 2026-09-23 | 2026-10-07 |
| External Beam Radiotherapy Followed by Bispecific Antibody Therapy for Relapsed/Refractory DLBCL Epcoritamab, Glofitamab, External Beam Radiation Therapy - Diffuse Large B Cell Lymphoma | Phase 1 | Recruiting | University of Utah | 12 | 2026-06-01 | 2026-06-04 |
| A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01 KRC-01, External Beam Radiation Therapy, cisplatin - Cervical Cancer | Phase 1 | Recruiting | Kortuc, Inc. | 70 | 2026-03-01 | 2026-04-08 |
| Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer Biospecimen Collection, Chemotherapy, Decitabine - Human Papillomavirus-Negative Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | Mayo Clinic | 32 | 2026-01-23 | 2026-07-15 |
| A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients Ascorbate, Gemcitabine, radiation therapy - Pancreatic Neoplasm | Phase 2 | Withdrawn | Joseph J. Cullen, MD, FACS | 2025-12-31 | 2025-03-10 | |
| Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care GammaTile®, External Beam Radiation Therapy, Temozolomide - Glioblastoma | Phase 3 | Recruiting | GT Medical Technologies, Inc. | 766 | 2025-12-10 | 2026-10-05 |
| Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial Biospecimen Collection, Chemotherapy, Computed Tomography - Ewing Sarcoma, Round Cell Sarcoma With EWSR1-non-ETS Fusion | Not applicable | Recruiting | Mayo Clinic | 170 | 2025-12-05 | 2026-10-06 |
| Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer Biospecimen Collection, Brachytherapy, Carboplatin - Locally Advanced Cervical Adenocarcinoma, Locally Advanced Cervical Adenosquamous Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2025-11-05 | 2026-10-22 |
| External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Extramedullary Disease in Multiple Myeloma, Multiple Myeloma | Phase 1 / Phase 2 | Suspended | City of Hope Medical Center | 20 | 2025-08-29 | 2026-10-07 |
| External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer Bevacizumab, Biospecimen Collection, Brachytherapy - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 1 / Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 35 | 2025-07-29 | 2026-08-12 |
| PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes, Biopsy, Biospecimen Collection - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Recruiting | City of Hope Medical Center | 21 | 2024-10-09 | 2026-08-21 |
| Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer Biospecimen Collection, Carboplatin, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 45 | 2024-03-21 | 2026-03-24 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer Biospecimen Collection, Bone Scan, Computed Tomography - Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 1500 | 2023-12-14 | 2026-10-23 |
| Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer Biospecimen Collection, Computed Tomography, External Beam Radiation Therapy - Biochemically Recurrent Prostate Carcinoma, Prostate Adenocarcinoma | Phase 1 | Active not recruiting | Emory University | 6 | 2023-11-29 | 2025-12-09 |
| Relugolix in Combination With Radiation Therapy for Treating Patients With High Risk Prostate Cancer Biospecimen Collection, Bone Scan, Brachytherapy - Stage IIC Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8 | Phase 2 | Not yet recruiting | University of Kansas Medical Center | 90 | 2023-11-20 | 2023-11-13 |
| Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Computed Tomography - Recurrent Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma | Early Phase 1 | Recruiting | City of Hope Medical Center | 9 | 2023-07-20 | 2026-02-04 |
| Imaging and Genomic Biomarkers to Predict Response in Prostate Cancer External beam radiation therapy, Prostate brachytherapy boost, Androgen deprivation therapy - Prostate Cancer | Early Phase 1 | Active not recruiting | University of Wisconsin, Madison | 30 | 2023-03-08 | 2026-06-02 |
| A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma Ferumoxytol injection, Pharmacological ascorbate, External beam radiation therapy - Glioblastoma, Glioblastoma Multiforme | Phase 1 | Active not recruiting | Bryan Allen | 16 | 2023-02-28 | 2026-07-20 |
| Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma Pembrolizumab - Cutaneous Squamous Cell Carcinoma of the Head and Neck, Head and Neck Cancer | Phase 2 | Recruiting | Queensland Health | 27 | 2022-06-28 | 2022-08-01 |
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Prostatic Neoplasms (20) · Uterine Cervical Neoplasms (19) · Glioblastoma (10) · Breast Neoplasms (9) · Pancreatic Neoplasms (5) · Radiation Injuries (5) · Squamous Cell Carcinoma of Head and Neck (5) · Ganglioneuroblastoma (4) · Neoplasm Metastasis (4) · Neoplasms (4) · Neuroblastoma (4) · Vaginal Neoplasms (4) · Adenocarcinoma Of Esophagus (3) · Carcinoma, Hepatocellular (3) · Carcinoma, Intraductal, Noninfiltrating (3)
National Cancer Institute (NCI) (16) · M.D. Anderson Cancer Center (9) · City of Hope Medical Center (6) · Mayo Clinic (5) · Children's Oncology Group (4) · Jonsson Comprehensive Cancer Center (4) · Albert Einstein College of Medicine (3) · Bryan Allen (3) · Memorial Sloan Kettering Cancer Center (3) · NRG Oncology (3) · Radiation Therapy Oncology Group (3) · Rutgers, The State University of New Jersey (3) · University of Washington (3) · Duke University (2) · Emory University (2)
United States (108) · Canada (21) · Puerto Rico (7) · Australia (4) · China (3) · France (3) · New Zealand (3) · Singapore (2) · South Korea (2) · Switzerland (2) · Austria (1) · Germany (1) · Hong Kong (1) · India (1) · Israel (1)
John M. Buatti, MD (3) · Allen K Sills, MD (2) · Bryan G. Allen, MD, PhD (2) · Charles Kunos (2) · Dennis Yi-Shin Kuo (2) · Jyoti S Mayadev (2) · Robert Montgomery (2) · Steven G DuBois (2) · Abraham Alexander, MD (1) · Adam L. Holtzman, MD (1) · Adam Luginbuhl, MD (1) · Adam P Dicker, MD, PhD (1) · Adam S. Kibel, MD (1) · Akiva Novetsky, MD (1) · Alain Zeimet (1)
PMID 34028986, PMID 38421243, PMID 17398031, PMID 19546404, PMID 20206777, PMID 21892091, PMID 22105720, PMID 22176868, PMID 23411385, PMID 23743570, PMID 24890347, PMID 24906700, PMID 26247543, PMID 26488758, PMID 26530748, PMID 27587597, PMID 27789196, PMID 28086825, PMID 28366679, PMID 29868473, PMID 30027292, PMID 30254147, PMID 30682445, PMID 31454045, PMID 31678224, PMID 31681600, PMID 31912685, PMID 32530765, PMID 32651467, PMID 32816895, PMID 32827353, PMID 33992718, PMID 34201380, PMID 34340209, PMID 35617923, PMID 36185311, PMID 36306810, PMID 36669140, PMID 37079324, PMID 37080223, PMID 37315297, PMID 37487144, PMID 37707811, PMID 37773633, PMID 38042451, PMID 38407630, PMID 38421252, PMID 38990564, PMID 39365957, PMID 39673591
U10CA180868 (10), U10CA180886 (6), P30CA033572 (4), U10CA027469 (4), U10CA098543 (4), P30CA013330 (3), P30CA015704 (3), P30CA072720 (3), P30CA086862 (2), P30CA138292 (2), U01CA062502 (2), U10CA021661 (2), P30CA012197 (1), P30CA043703 (1), P30CA168524 (1)