16 recruiting, 11 active not recruiting, 11 completed, 5 unknown. 18 Not applicable, 17 Phase 3, 13 Phase 2, 3 Early Phase 1, 3 Phase 4.
Follow Expectant management: new trials by email Literature Review of Expectant management trials Research Report on Expectant management
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information Biospecimen Collection, Chest Radiography, Computed Tomography - Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8 | Phase 2 | Recruiting | Children's Oncology Group | 51 | 2027-05-15 | 2026-09-24 |
| Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial Atezolizumab, Atezolizumab and Recombinant Human Hyaluronidase, Biospecimen Collection - Lung Non-Small Cell Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2027-03-02 | 2026-10-23 |
| Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain Biospecimen Collection, Low-Dose Aspirin, Patient Observation - Endometrial Carcinoma | Phase 4 | Not yet recruiting | Mayo Clinic | 20 | 2027-02-12 | 2026-08-05 |
| Testing the Investigational Medication Pembrolizumab After Kidney Removal for Patients With Non-Clear Cell Renal Cell Carcinoma Biospecimen Collection, Bone Scan, Computed Tomography - Non-Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 | Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 400 | 2027-02-10 | 2026-07-08 |
| Planned Early Induction of Labor vs Expectant Management for PROM Induction of labor with PGE2, Expectant management - Premature Rupture of Membranes (PROM) | Not applicable | Enrolling by invitation | Pakistan Institute of Medical Sciences | 734 | 2026-05-01 | 2026-09-03 |
| Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease Biospecimen Collection, Dasatinib, Fisetin - Glioma | Early Phase 1 | Recruiting | Mayo Clinic | 30 | 2025-08-12 | 2026-10-01 |
| A RCT of Labor Induction at 39 Weeks in Low - Risk Women in China Labor Induction at 39 Weeks, Expectant management - Cesarean Delivery | Not applicable | Recruiting | Women's Hospital School Of Medicine Zhejiang University | 1074 | 2025-07-30 | 2026-07-30 |
| Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial Best Practice, Biospecimen Collection, Bone Metastases Treatment - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 3 | Active not recruiting | NRG Oncology | 280 | 2025-05-07 | 2026-08-17 |
| A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) Bone Scan, Carboplatin, Computed Tomography - Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor | Phase 3 | Recruiting | Children's Oncology Group | 1656 | 2025-04-15 | 2026-08-25 |
| Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial Biospecimen Collection, Computed Tomography, Durvalumab - Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 306 | 2025-04-01 | 2026-10-19 |
| Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma Biospecimen Collection, Bone Scan, Computed Tomography - Pleuropulmonary Blastoma | Phase 3 | Recruiting | Children's Oncology Group | 110 | 2025-03-21 | 2026-08-25 |
| Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance Biopsy of Prostate, Biospecimen Collection, Magnetic Resonance Imaging - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Phase 4 | Recruiting | Roswell Park Cancer Institute | 600 | 2025-01-15 | 2026-05-14 |
| Active Surveillance for the Treatment of Low-Risk Basal Cell Carcinoma in Elderly Patients Best Practice, Educational Activity, Patient Observation - Skin Basal Cell Carcinoma | Not applicable | Active not recruiting | University of Michigan Rogel Cancer Center | 81 | 2024-10-08 | 2026-06-23 |
| Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial Abiraterone, Apalutamide, Biospecimen Collection - Recurrent Castration-Sensitive Prostate Carcinoma, Recurrent Prostate Cancer | Phase 2 | Recruiting | Mayo Clinic | 532 | 2024-06-03 | 2026-07-20 |
| Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer Chemotherapy, Patient Observation, Questionnaire Administration - Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8 | Early Phase 1 | Recruiting | M.D. Anderson Cancer Center | 120 | 2024-03-13 | 2026-05-20 |
| Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy Biopsy, Biospecimen Collection, Computed Tomography - Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Primary Mediastinal Large B-Cell Lymphoma | Phase 2 | Recruiting | Academic and Community Cancer Research United | 120 | 2024-01-31 | 2024-09-26 |
| Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma Axicabtagene Ciloleucel, Biospecimen Collection, Computed Tomography - Diffuse Large B-Cell Lymphoma, Grade 3b Follicular Lymphoma | Phase 2 | Recruiting | SWOG Cancer Research Network | 396 | 2023-06-12 | 2026-10-15 |
| Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung Atezolizumab, Biospecimen Collection, Carboplatin - Advanced Extrapulmonary Neuroendocrine Carcinoma, Metastatic Extrapulmonary Neuroendocrine Carcinoma | Phase 2 / Phase 3 | Recruiting | National Cancer Institute (NCI) | 189 | 2022-06-28 | 2026-10-23 |
| Removal of Intrauterine Retained Products of Conception (RPOC) After Miscarriage Guided by Hysteroscopy Trial. A Randomized Controlled Trial. Operative hysteroscopy, Expectant management - Retained Products of Conception | Not applicable | Recruiting | University Hospital, Ghent | 244 | 2021-07-12 | 2026-07-30 |
| White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA Clinical Observation, Patient Observation, Questionnaire Administration - Prostate Adenocarcinoma, PSA Failure | Phase 2 | Suspended | City of Hope Medical Center | 133 | 2021-05-10 | 2026-08-10 |
Showing 20 of 54. Sign in to see all of them.
Pregnancy, Ectopic (3) · Prostatic Neoplasms (3) · Abortion, Incomplete (2) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Ductus Arteriosus, Patent (2) · Endometriosis (2) · Lymphoma, Large B-Cell, Diffuse (2) · Melanoma (2) · Oropharyngeal Neoplasms (2) · Premature Birth (2) · Abortion, Spontaneous (1) · Anal Canal Carcinoma (1) · Anus Neoplasms (1)
National Cancer Institute (NCI) (10) · Mayo Clinic (5) · Children's Oncology Group (4) · M.D. Anderson Cancer Center (2) · NRG Oncology (2) · Ospedale Policlinico San Martino (2) · Roswell Park Cancer Institute (2) · SWOG Cancer Research Network (2) · Academic and Community Cancer Research United (1) · Birmingham Women's and Children's NHS Foundation Trust (1) · City of Hope Medical Center (1) · ECOG-ACRIN Cancer Research Group (1) · HaEmek Medical Center, Israel (1) · Heilongjiang University of Chinese Medicine (1) · Lviv National Medical University (1)
United States (36) · Canada (10) · Puerto Rico (4) · Australia (2) · China (2) · Israel (2) · Italy (2) · New Zealand (2) · Saudi Arabia (2) · United Kingdom (2) · Belgium (1) · Pakistan (1) · Panama (1) · South Korea (1) · Ukraine (1)
Ahmed Aly (1) · Alexander Shoushtari (1) · Allison Billi (1) · Anat Hershko Klement, MD (1) · Anne Steiner, MD MPH (1) · Antoine Naem, M.D. (1) · Brian T Hess (1) · Brittani K Seynnaeve (1) · Chad G Ball, MD (1) · Christopher C. DeStephano, MD, MPH (1) · Christos Coutifaris, MD PhD (1) · Clayton S Lau (1) · Dan Zhang, Ph. D. (1) · Daniel J. Ma, M.D. (1)
PMID 10914623, PMID 14586353, PMID 15454805, PMID 16055573, PMID 16307931, PMID 16522419, PMID 17161082, PMID 17621365, PMID 17650692, PMID 17825674, PMID 18053373, PMID 19038077, PMID 19457604, PMID 20132984, PMID 21307755, PMID 22310111, PMID 22905470, PMID 22929504, PMID 23433600, PMID 25983221, PMID 29502092, PMID 31296180, PMID 33526329, PMID 34147090, PMID 34342619, PMID 34477473, PMID 38942046, PMID 39390760, PMID 40029972, PMID 41364689, PMID 41693026, PMID 41825136, PMID 42117295, PMID 42335416, PMID 42749373, PMID 7485303, PMID 9548180
U10CA180820 (6), U10CA180886 (4), U10CA180888 (4), U10CA180821 (2), P30CA015083 (1), P30CA016056 (1), P30CA033572 (1), P30CA042014 (1), R01CA286127 (1), R01CA300454 (1), U10CA180868 (1), U10HD055925 (1), UG1CA189867 (1), UG1CA189974 (1), UG1HD112079 (1)