13 completed, 1 terminated, 1 withdrawn. 15 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Completed 13, Terminated 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 3 |
Follow epothilone B: new trials by email Literature Review of epothilone B trials Research Report on epothilone B
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patupilone (EPO 906) in Patients With Recurrent or Progressive Glioblastoma Patupilone - Recurrent Glioblastoma Planned for Reoperation | Phase 1 / Phase 2 | Completed | University of Zurich | 9 | 2008-07-01 | 2011-09-15 |
| Phase I Study of Patupilone and RAD001 Patupilone, RAD001 - Refractory Malignancy | Phase 1 | Completed | University of Medicine and Dentistry of New Jersey | 42 | 2007-07-01 | 2012-06-14 |
| Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension) Patupilone, Patupilone + Omeprazole - Solid Tumors | Phase 1 | Withdrawn | Novartis Pharmaceuticals | 2007-07-01 | 2012-04-25 | |
| The Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies Patupilone - Advanced Malignancies | Phase 1 | Terminated | Novartis Pharmaceuticals | 12 | 2007-05-01 | 2009-11-19 |
| Evaluate the Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies Patupilone - Advanced Malignancies | Phase 1 | Completed | Novartis Pharmaceuticals | 17 | 2007-03-01 | 2009-11-19 |
| Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies Patupilone and Omeprazole, Patupilone + Midalzolam - Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 34 | 2006-12-01 | 2020-12-08 |
| Efficacy and Safety of Patupilone in Patients With Advanced Solid Tumors in Japan Patupilone - Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 15 | 2006-08-01 | 2010-05-31 |
| Pharmacokinetics of Patupilone After a Single Intravenous Administration in Patients With Advance Solid Tumor Malignancies. Patupilone - Advanced Malignancies, Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 5 | 2006-08-01 | 2020-12-08 |
| Combination Trial of Patupilone and Carboplatin in Adult Patients With Advanced Solid Tumors Patupilone - Advanced Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 48 | 2006-08-01 | 2020-12-09 |
| A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function Patupilone/EPO906 - Advanced Malignancies, Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 14 | 2006-05-01 | 2012-01-11 |
| A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function Patupilone/EPO906 - Advanced Malignancies, Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 36 | 2006-01-01 | 2020-12-09 |
| Phase I/II Study of Celebrex and EPO906 in Patients With Metastatic Colorectal Cancer EPO906, Celecoxib - Colon Cancer, Colorectal Cancer | Phase 1 / Phase 2 | Completed | University of Southern California | 75 | 2004-10-12 | 2026-05-28 |
| EPO906 Plus Radiation Therapy for the Treatment of Cancer Patients EPO906 (epothilone B) - Central Nervous System Neoplasms, Head and Neck Neoplasms | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 39 | 2004-02-01 | 2025-05-02 |
| Dose-Escalation Study in Advanced Colon Cancer Patients EPO906 (patupilone) - Colon Cancer | Phase 1 | Completed | Novartis Pharmaceuticals | 60 | 2003-11-01 | 2020-12-08 |
| Dose Escalating Study of the Safety and Efficacy of Patupilone, q3w, in Patients With Non-small Cell Lung Cancer Patupilone - Carcinoma, Non-Small-Cell Lung | Phase 1 / Phase 2 | Completed | Novartis Pharmaceuticals | 89 | 2003-08-01 | 2014-02-05 |
Neoplasms (9) · Colonic Neoplasms (2) · Brain Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Central Nervous System Neoplasms (1) · Colorectal Neoplasms (1) · Glioblastoma (1) · Head and Neck Neoplasms (1) · Lung Neoplasms (1)
Novartis Pharmaceuticals (11) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Medicine and Dentistry of New Jersey (1) · University of Southern California (1) · University of Zurich (1)
United States (11) · Czechia (1) · France (1) · Japan (1) · Spain (1) · United Kingdom (1)
Adam Dicker, MD, PhD (1) · Heinz-Josef Lenz, M.D. (1) · Mark Stein, MD (1) · Silvia Hofer, MD (1)