26 completed, 1 terminated, 1 withdrawn. 15 Phase 1, 15 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Completed 13, Terminated 1, Withdrawn 1 |
| Phase 2 | 15 | Completed 15 |
| Phase 3 | 1 | Completed 1 |
Follow epothilone B: new trials by email Literature Review of epothilone B trials Research Report on epothilone B
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patupilone (EPO 906) in Patients With Recurrent or Progressive Glioblastoma Patupilone - Recurrent Glioblastoma Planned for Reoperation | Phase 1 / Phase 2 | Completed | University of Zurich | 9 | 2008-07-01 | 2011-09-15 |
| Phase I Study of Patupilone and RAD001 Patupilone, RAD001 - Refractory Malignancy | Phase 1 | Completed | University of Medicine and Dentistry of New Jersey | 42 | 2007-07-01 | 2012-06-14 |
| Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension) Patupilone, Patupilone + Omeprazole - Solid Tumors | Phase 1 | Withdrawn | Novartis Pharmaceuticals | 2007-07-01 | 2012-04-25 | |
| The Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies Patupilone - Advanced Malignancies | Phase 1 | Terminated | Novartis Pharmaceuticals | 12 | 2007-05-01 | 2009-11-19 |
| Evaluate the Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies Patupilone - Advanced Malignancies | Phase 1 | Completed | Novartis Pharmaceuticals | 17 | 2007-03-01 | 2009-11-19 |
| Study of Patupilone in Prostate Cancer Patients Who Progress After Hormone Therapy and Docetaxel Chemotherapy Patupilone - Hormone Refractory Prostate Cancer | Phase 2 | Completed | British Columbia Cancer Agency | 73 | 2007-02-01 | 2010-11-05 |
| Epothilone B in Treating Patients With CNS Metastases From Breast Cancer epothilone B - Breast Cancer, Metastatic Cancer | Phase 2 | Completed | David Peereboom, MD | 55 | 2007-01-01 | 2014-02-28 |
| Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies Patupilone and Omeprazole, Patupilone + Midalzolam - Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 34 | 2006-12-01 | 2020-12-08 |
| Efficacy and Safety of Patupilone in Men (≥18 Years) With Metastatic Hormone Refractory Prostate Cancer Patupilone, prednisone, docetaxel - Metastatic Hormone Refractory Prostate Cancer | Phase 2 | Completed | Novartis Pharmaceuticals | 185 | 2006-09-01 | 2020-12-17 |
| Efficacy and Safety of Patupilone in Patients With Advanced Solid Tumors in Japan Patupilone - Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 15 | 2006-08-01 | 2010-05-31 |
| Pharmacokinetics of Patupilone After a Single Intravenous Administration in Patients With Advance Solid Tumor Malignancies. Patupilone - Advanced Malignancies, Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 5 | 2006-08-01 | 2020-12-08 |
| Combination Trial of Patupilone and Carboplatin in Adult Patients With Advanced Solid Tumors Patupilone - Advanced Solid Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 48 | 2006-08-01 | 2020-12-09 |
| A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function Patupilone/EPO906 - Advanced Malignancies, Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 14 | 2006-05-01 | 2012-01-11 |
| Patupilone Activity in Advanced/Metastatic Hepatocellular Carcinoma Patupilone - Hepatocellular Carcinoma | Phase 2 | Completed | Novartis Pharmaceuticals | 25 | 2006-01-01 | 2017-02-07 |
| A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function Patupilone/EPO906 - Advanced Malignancies, Tumors | Phase 1 | Completed | Novartis Pharmaceuticals | 36 | 2006-01-01 | 2020-12-09 |
| Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer Patupilone - Brain Metastasis, Non-small Cell Lung Cancer | Phase 2 | Completed | Novartis Pharmaceuticals | 50 | 2005-11-16 | 2021-02-21 |
| Patupilone Versus Doxorubicin in Patients With Ovarian, Primary Fallopian, or Peritoneal Cancer EPO906 (Patupilone), doxorubicin - Ovarian Cancer, Fallopian Tube Cancer | Phase 3 | Completed | Novartis Pharmaceuticals | 829 | 2005-11-01 | 2020-12-17 |
| Phase I/II Study of Celebrex and EPO906 in Patients With Metastatic Colorectal Cancer EPO906, Celecoxib - Colon Cancer, Colorectal Cancer | Phase 1 / Phase 2 | Completed | University of Southern California | 75 | 2004-10-12 | 2026-05-28 |
| EPO906 Plus Radiation Therapy for the Treatment of Cancer Patients EPO906 (epothilone B) - Central Nervous System Neoplasms, Head and Neck Neoplasms | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 39 | 2004-02-01 | 2025-05-02 |
| Dose-Escalation Study in Advanced Colon Cancer Patients EPO906 (patupilone) - Colon Cancer | Phase 1 | Completed | Novartis Pharmaceuticals | 60 | 2003-11-01 | 2020-12-08 |
Showing 20 of 28. Sign in to see all of them.
Neoplasms (17) · Carcinoma (5) · Brain Neoplasms (3) · Colonic Neoplasms (3) · Neoplasm Metastasis (3) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Colorectal Neoplasms (2) · Fallopian Tube Neoplasms (2) · Lung Neoplasms (2) · Ovarian Neoplasms (2) · Peritoneal Neoplasms (2) · Prostatic Neoplasms (2) · Breast Neoplasms, Male (1) · Carcinoid Tumor (1)
Novartis Pharmaceuticals (22) · British Columbia Cancer Agency (1) · David Peereboom, MD (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Medicine and Dentistry of New Jersey (1) · University of Southern California (1) · University of Zurich (1)
United States (23) · France (4) · Canada (3) · Spain (3) · United Kingdom (3) · Australia (2) · Italy (2) · Belgium (1) · Czechia (1) · Denmark (1) · Finland (1) · Germany (1) · Greece (1) · Hong Kong (1) · Japan (1)
Adam Dicker, MD, PhD (1) · David M. Peereboom, MD (1) · Heinz-Josef Lenz, M.D. (1) · Joseph Baar, MD (1) · Kim Chi, MD (1) · Mark Stein, MD (1) · Silvia Hofer, MD (1)
PMID 22987083, PMID 23509629, PMID 24722180, PMID 37407274
P30CA043703 (1)