32 completed. 32 Phase 3, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 32 | Completed 32 |
| Phase 2 | 9 | Completed 9 |
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section Epinephrine (Adrenaline) bolus then infusion, Epinephrine (Adrenaline) infusion - Hemodynamic (MAP) Stability | Phase 3 | Completed | Cairo University | 80 | 2026-03-18 | 2026-08-28 |
| Can PLIA Reduce Early Post-operative Pain After PAO Surgery? Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline) - Hip Dysplasia | Phase 2 / Phase 3 | Completed | Michael C Willey | 121 | 2024-10-03 | 2026-10-07 |
| Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L in Children 4% Articaine Hydrochloride with 1:100,000 Adrenaline, 2% Mepivacaine Hydrochloride with 1:20,000 Levonordefrin - Local Anesthesia | Phase 3 | Completed | Cairo University | 10 | 2021-08-01 | 2023-03-14 |
| Efficacy of SLN Block for Chronic Cough Superior laryngeal nerve block, Injection of placebo (saline), Injection of steroid-lidocaine mixture - Cough, Superior Laryngeal Nerve Block | Phase 3 | Completed | Medical University of South Carolina | 17 | 2020-07-22 | 2025-10-23 |
| RCT of Gastric ESD With or Without Epineprhine Added Solution Endoscopic submucosal dissection, Epinephrine - Gastric Neoplasm, Early Gastric Cancer | Phase 3 | Completed | Chinese University of Hong Kong | 800 | 2020-01-10 | 2025-05-04 |
| Surgicel and Analgesic Reservoir "Local Anesthetic", "Epinephrine" and "Morphine", "Local Anesthetic", "Epinephrine", "Morphine" and "Surgicel", "Normal Saline" - Postoperative Pain | Phase 2 / Phase 3 | Completed | Assiut University | 90 | 2018-11-15 | 2020-08-18 |
| An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA CNTX-4975-05, Lidocaine without epinephrine, ElastoGel - Knee Osteoarthritis | Phase 3 | Completed | Centrexion Therapeutics | 854 | 2018-09-18 | 2022-03-09 |
| Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty Quadratus Lumborum Block (QLB), Standard of Care - Total Hip Arthroplasty | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 80 | 2018-04-01 | 2021-06-09 |
| Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Topical epinephrine, Placebos - Lung Transplant; Complications, Mechanical, Lung Transplant; Complications | Phase 2 / Phase 3 | Completed | University of Maryland, Baltimore | 66 | 2017-07-01 | 2024-08-28 |
| Effect of Lidocaine/Dexamethasone on the Success of IANB 2% lidocaine with 1:80,000 epinephrine, Dexamethasone, Placebo - Local Anesthesia | Phase 2 / Phase 3 | Completed | Isfahan University of Medical Sciences | 100 | 2016-08-01 | 2018-05-22 |
| Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis Caudal Nerve Block (CNB), Ropivacaine, Epinephrine - Malignant Neoplasms of Male Genital Organs | Phase 3 | Completed | M.D. Anderson Cancer Center | 52 | 2016-06-01 | 2022-01-24 |
| Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery PECS "Pectoralis" 1 and 2 Blocks, Interscalene Block, Sham Block - Biceps Tendonitis | Phase 3 | Completed | Wake Forest University Health Sciences | 40 | 2016-04-01 | 2018-08-27 |
| To Compare a Hemostatic Powder TC-325 and Standard Treatment in the Control of Acute Upper Gastrointestinal Bleeding From Nonvariceal Causes Endoscopic Application of a Hemostatic Powder TC-325, Hemo-clipping, Epinephrine - Acute Upper Gastrointestinal Bleeding | Phase 3 | Completed | Chinese University of Hong Kong | 224 | 2015-09-07 | 2019-10-11 |
| Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008) Short ragweed pollen allergen extract, Placebo, Self-injectable epinephrine - Rhinitis, Allergic, Seasonal | Phase 3 | Completed | Merck Sharp & Dohme LLC | 1025 | 2015-07-20 | 2019-09-06 |
| Ultrasound-guided Nerve Block: Determination of the Minimal Effective Volume of Local Anesthetic median nerve block - Surgery | Phase 2 / Phase 3 | Completed | Hopital Foch | 52 | 2015-05-21 | 2020-07-22 |
| The Effect of the Serratus Block on Pain Control After Breast Surgery Serratus Block, Placebo Block, ropivacaine - Anesthesia | Phase 2 / Phase 3 | Completed | Women's College Hospital | 40 | 2014-10-29 | 2020-01-13 |
| 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis 4%articaine, 2% Lignocaine, Epinephrine - Irreversible Pulpitis | Phase 3 | Completed | Dr. D. Y. Patil Dental College & Hospital | 25 | 2014-06-01 | 2016-06-21 |
| Pain Management Following Total Hip Arthroplasty ropivacaine + ketorolac + adrenaline - Postoperative Pain Intensity, Rescue Pain Requirements | Phase 3 | Completed | Örebro University, Sweden | 55 | 2014-05-01 | 2016-09-27 |
| Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy Ropivacaine with epinephrine injection, Placebo - Thyroid Neoplasm, Goiter | Phase 3 | Completed | Seoul National University Hospital | 148 | 2014-05-01 | 2017-08-04 |
| Patient Experience Study of Deoxycholic Acid Injection Deoxycholic Acid Injection, Placebo, Cold Compress - Moderate or Severe Submental Fullness | Phase 3 | Completed | Kythera Biopharmaceuticals | 84 | 2013-12-01 | 2015-07-28 |
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Pain, Postoperative (4) · Pain (3) · Asthma (2) · Diabetes Insipidus (2) · Dyspnea (2) · Heart Arrest (2) · Agnosia (1) · Cardiac Output, Low (1) · Chronic Cough (1) · Cough (1) · Goiter (1) · Hemoptysis (1) · Hemorrhage (1) · Hemorrhoids (1) · Hip Dislocation (1)
Amphastar Pharmaceuticals, Inc. (2) · Cairo University (2) · Chinese University of Hong Kong (2) · Assiut University (1) · CHA University (1) · Centrexion Therapeutics (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dr. D. Y. Patil Dental College & Hospital (1) · Göteborg University (1) · Hopital Foch (1) · Isfahan University of Medical Sciences (1) · Kythera Biopharmaceuticals (1) · M.D. Anderson Cancer Center (1) · Masoud Saatchi (1) · Medical University of South Carolina (1)
United States (12) · Egypt (3) · South Korea (3) · France (2) · Singapore (2) · Sweden (2) · Canada (1) · China (1) · Denmark (1) · Greece (1) · Hong Kong (1) · Iran (1) · Japan (1)
Anil Gupta, MD, PhD (1) · Bobby Bellard, MD (1) · Charis Roussos, MD, PhD (1) · Courtney Tipton (1) · Djillali Annane, MD, PhD (1) · Elisabeth Stadberg, MD (1) · Eric Bellissant, MD, PhD (1) · Eric Dufour, MD (1) · Esam A. Hamed, M.D. (1) · Fatma Backman, MD (1) · Frederick Beddingfield, III, MD, PhD (1) · Hon Chi Yip, MBChB, FRCSEd (1) · J.Wells Reynolds, MD (1) · Karin Olausson, MD (1)
PMID 31959019, PMID 17470271, PMID 17720019, PMID 22353644, PMID 22900785, PMID 23860985, PMID 26821696, PMID 27787269, PMID 28562541, PMID 30904852, PMID 31136331, PMID 31653800, PMID 32304832, PMID 32548677, PMID 32926419, PMID 33492696, PMID 33929377, PMID 34871051, PMID 34886880, PMID 34990764, PMID 34996918, PMID 37140517, PMID 41620139
2014 (2)