52 unknown, 13 completed, 2 not yet recruiting. 48 Phase 2, 8 Phase 3, 5 Phase 4, 4 Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 48 | Unknown 36, Completed 10, Not yet recruiting 2 |
| Phase 3 | 8 | Unknown 7, Completed 1 |
| Phase 4 | 5 | Unknown 4, Completed 1 |
| Phase 1 | 4 | Unknown 3, Completed 1 |
| Not applicable | 2 | Unknown 2 |
Follow Endostar: new trials by email Literature Review of Endostar trials Research Report on Endostar
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SRT Combined With Envafolimab and Endostar in the First-line Treatment of Advanced NSCLC Stereotactic Radiation Therapy, Envafolimab, Endostar - Non Small Cell Lung Cancer, Lung Neoplasms | Phase 2 | Not yet recruiting | The First People's Hospital of Lianyungang | 61 | 2026-10-01 | 2026-09-14 |
| Local Injection and Systemic Therapy in the Treatment of NSCLC. Envafolimab, Recombinant human endostatin, recombinant human adenovirus type 5 - Non-small Cell Lung Cancer | Phase 2 | Not yet recruiting | Henan Cancer Hospital | 84 | 2024-10-08 | 2024-10-01 |
| Endostar Combined With SBRT and Envafolimab in the Treatment of Advanced Gastrointestinal Tumors Envafolimab Injection, Endostar - Gastrointestinal Neoplasms | Phase 2 | Unknown | Nanjing First Hospital, Nanjing Medical University | 16 | 2024-02-21 | 2024-03-08 |
| Envafolimab Combined With Endostar and Concurrent Chemoradiotherapy for Locally Advanced Primary Cervical Cancer cis-platinum, radiation, Envafolimab Injection - Cervical Cancer | Unknown | Peking University Third Hospital | 30 | 2023-05-16 | 2023-05-30 | |
| Envafolimab Combined With Endostar and Chemotherapy for First-line Treatment of Advanced Pancreatic Cancer Envafolimab, Endostar, Nab paclitaxel - Advanced Pancreatic Cancer | Phase 2 | Unknown | The Affiliated Hospital of Xuzhou Medical University | 20 | 2022-04-01 | 2022-03-28 |
| Envafolimab Combined With Endostar in the First-line Treatment of Advanced NSCLC Envafolimab, Endostar - Lung Neoplasms | Phase 2 | Unknown | The First People's Hospital of Lianyungang | 40 | 2022-03-01 | 2023-06-22 |
| PK Study for Endostar Continuous Intravenous Infusion in NSCLC Patients With 1st-line Platinum Based Chemotherapy Endostar, use the vein pump to pump drugs, combination therapy - Advanced or Metastatic NSCLC | Phase 1 | Unknown | Jiangsu Simcere Pharmaceutical Co., Ltd. | 24 | 2021-07-30 | 2021-06-30 |
| Endostar Combined With Corticosteroid for Treatment of Radiation-induced Brain Necrosis in Nasopharyngeal Carcinoma Endostar - Nasopharyngeal Carcinoma | Phase 2 | Unknown | Jiangxi Provincial Cancer Hospital | 30 | 2021-07-28 | 2022-01-04 |
| SBRT With S1 Combined With Endostar in the Treatment of Lung Cancer Endostar - Radiotherapy Side Effect | Not applicable | Unknown | Peking University Third Hospital | 60 | 2020-04-01 | 2020-03-19 |
| Endostar Plus Toripalimab as Adjuvant Therapy for Resectable Stage III-Oligometastatic Stage IV Cutaneous Melanoma Endostar, Toripalimab - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8 | Phase 2 | Unknown | Fudan University | 43 | 2020-04-01 | 2023-06-22 |
| Camrelizumab Combined With Endostar for First-line Treatment in Subjects With Advanced Squamous NSCLC Camrelizumab - Non-small Cell Lung Cancer | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 52 | 2019-12-31 | 2020-03-10 |
| Endostar/PD-1 Inhibitors Combined With PP for Advanced NSCLC endostar/PD-1 inhibitor, endostar - Non-squamous Non-small Cell Lung Cancer | Not applicable | Unknown | Dong Wang | 170 | 2019-08-20 | 2019-08-21 |
| CCRT Combined With Endostar for the Treatment of Locally Advanced Cervical Cancer Radiotherapy, Endostar, Cisplatin - Cervical Cancer | Phase 2 | Unknown | Zhejiang Cancer Hospital | 82 | 2019-08-01 | 2019-10-10 |
| Second-Line Chemotherapy Combined With Endostatin for Recurrent/Metastatic HN Epithelial Tumors second-line chemotherapy, Recombinant human endostatin - Head and Neck Neoplasms | Phase 2 | Unknown | Sun Yan | 53 | 2019-07-29 | 2020-10-23 |
| Endostar Combined With Induction Chemotherapy and Concurrent Chemoradiotherapy for Locoregional Nasopharyngeal Carcinoma Endostar, Cisplatin, Docetaxel - Nasopharyngeal Carcinoma | Phase 2 | Unknown | Jiangsu Cancer Institute & Hospital | 73 | 2019-06-01 | 2019-04-30 |
| Endostatin Combined With Chemotherapy for Adjuvant Treatment of Esophageal Cancer Docetaxel, Nedaplatin, Endostar - Esophageal Cancer | Phase 2 | Unknown | First Affiliated Hospital of Guangxi Medical University | 186 | 2018-11-01 | 2018-08-28 |
| Rh-Endostatin (Endostar®) Continuous Intravenous Infusion Endostar, Docetaxel, Carboplatin - Lung Cancer | Phase 2 | Unknown | Affiliated Cancer Hospital & Institute of Guangzhou Medical University | 50 | 2018-10-01 | 2018-10-17 |
| Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis Endostar, standard SRILI treatment - Radiation Pneumonitis, Endostatin | Phase 2 | Completed | Xinqiao Hospital of Chongqing | 126 | 2018-09-01 | 2024-02-23 |
| Endostar Combined With IP Second-line Treatment of Advanced Esophageal Squamous Cell Carcinomas Irinotecan, DDP, Endostar - Esophageal Squamous Cell Carcinoma | Phase 2 | Completed | Fudan University | 52 | 2017-05-04 | 2025-07-23 |
| Endostar Combined With Chemotherapy for Stage Ⅳ Soft Tissue Sarcoma Endostar, Placebo, AIM regimen / GT regimen - Soft Tissue Sarcoma, Adult, Stage IIB | Phase 2 | Completed | Tianjin Medical University Cancer Institute and Hospital | 52 | 2017-05-01 | 2019-12-26 |
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Carcinoma, Non-Small-Cell Lung (18) · Nasopharyngeal Carcinoma (7) · Lung Neoplasms (6) · Colorectal Neoplasms (4) · Esophageal Squamous Cell Carcinoma (3) · Uterine Cervical Neoplasms (3) · Breast Neoplasms (2) · Esophageal Neoplasms (2) · Lymphoma, T-Cell, Peripheral (2) · Melanoma (2) · Nasopharyngeal Neoplasms (2) · Sarcoma (2) · Adenocarcinoma of Lung (1) · Brain Neoplasms (1) · Gastrointestinal Neoplasms (1)
Fudan University (6) · Jiangsu Simcere Pharmaceutical Co., Ltd. (6) · Zhejiang Cancer Hospital (5) · First Affiliated Hospital of Guangxi Medical University (3) · Nanjing NingQi Medicine Science and Technology Co., Ltd. (3) · Peking University Third Hospital (3) · Simcere Pharmaceutical Co., Ltd (3) · Peking University Cancer Hospital & Institute (2) · Shandong Simcere-Medgenn Bio-pharmaceutical Co., Ltd (2) · Shanghai Jiao Tong University School of Medicine (2) · Sun Yat-sen University (2) · The First People's Hospital of Lianyungang (2) · Tianjin Medical University Cancer Institute and Hospital (2) · Xinqiao Hospital of Chongqing (2) · Affiliated Cancer Hospital & Institute of Guangzhou Medical University (1)
China (59)
Xiaodong Jiang, MD (2) · Bin Li (1) · Changgui Wu, MD, PHD (1) · Dong Wang, PH.D (1) · Fei Han, M.D., Ph.D. (1) · Guoliang Jiang, MD (1) · Hanmei Lou, PHD (1) · Hongbo Wu, M.D. (1) · Jia Chen, MD (1) · Jian Fang (1) · Jie He, M.D. & Ph.D. (1) · Jilong Yang, M.D., Ph.D. (1) · Jin Li, MD (1) · Junning Cao, MD (1)
PMID 10640954, PMID 11212235, PMID 15172975, PMID 15746043, PMID 15752890, PMID 15920746, PMID 16139912, PMID 19564532, PMID 22099051, PMID 22209574, PMID 22496834, PMID 22537906, PMID 22562140, PMID 23670576, PMID 25198661, PMID 25244494, PMID 25497558, PMID 26434908, PMID 27067521, PMID 27566586, PMID 35380726, PMID 41014160, PMID 41049580