4 completed, 1 not yet recruiting, 1 terminated, 1 unknown. 6 Phase 2, 2 Phase 3, 1 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 3, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Unknown 1 |
Follow double placebo: new trials by email Literature Review of double placebo trials Research Report on double placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF Henggliflozin Combined with Probiotics, Henggliflozin, double placebo - Heart Failure, Preserved Ejection Fraction | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 162 | 2026-07-01 | 2026-07-07 |
| Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV Metformin, Placebo, Fluoxetine - Depression, Hiv | Phase 2 | Withdrawn | University of Minnesota | 2026-07-01 | 2026-07-10 | |
| Oral Hyoscine vs Lidocaine-Prilocaine Spray vs Placebo for HSG Pain Relief Oral Hyoscine butylbromide and Placebo Spray, Topical lidocaine-prilocaine spray and placebo oral tablet, Double Placebo - Hysterosalpingography | Not applicable | Completed | Cairo University | 102 | 2025-10-03 | 2026-06-11 |
| Manage Diarrhea in Patients With Multiple Myeloma While Receiving Conditioning Chemotherapy for Autologous SCT Serum-derived bovine immunoglobulin/protein isolate (SBI), Colesevelam, Double Placebo - Multiple Myeloma | Phase 2 | Terminated | Mayo Clinic | 4 | 2016-04-01 | 2017-06-14 |
| Safety and Efficacy of Allogeneic Cells for the Treatment of Intermittent Claudication(IC) PLX-PAD Low dose, PLX-PAD high doses, Double Placebo - Intermittent Claudication, Peripheral Artery Disease | Phase 2 | Completed | Pluristem Ltd. | 180 | 2012-11-05 | 2019-02-12 |
| Efficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder transcranial direct current stimulation, Sertraline, double placebo - Depressive Disorder, Major | Phase 2 / Phase 3 | Completed | University of Sao Paulo | 120 | 2009-12-01 | 2011-12-06 |
| The Long-term Evaluation of Glucosamine Sulphate Study Glucosamine sulphate and chondroitin, Glucosamine sulphate, Chondroitin sulphate - Osteoarthritis, Knee | Phase 4 | Unknown | University of Sydney | 600 | 2007-10-01 | 2010-06-30 |
| Aripiprazole and Topiramate on Free-Choice Alcohol Use Double Placebo, Aripiprazole 15, placebo, Aripiprazole 7.5, Placebo - Alcohol Dependence | Phase 2 / Phase 3 | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 90 | 2007-09-01 | 2015-10-07 |
Acquired Immunodeficiency Syndrome (1) · Alcoholism (1) · Depression (1) · Depressive Disorder, Major (1) · Disease Progression (1) · Heart Failure, Diastolic (1) · Intermittent Claudication (1) · Multiple Myeloma (1) · Osteoarthritis, Knee (1) · Peripheral Arterial Disease (1)
Cairo University (1) · Mayo Clinic (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · Pluristem Ltd. (1) · The First Affiliated Hospital of Air Force Medicial University (1) · University of Minnesota (1) · University of Sao Paulo (1) · University of Sydney (1)
United States (3) · Australia (1) · Brazil (1) · China (1) · Egypt (1) · Germany (1) · Israel (1) · South Korea (1)
Alan T Hirsch, MD (1) · Andre R Brunoni, MD (1) · Berthold Amann, MD (1) · Bret Weichmann, MD (1) · Changyoung Lim, MD (1) · Charles Bridges-Webb, MB, BS (1) · Christine Espinola-Klein, MD (1) · David L Fried, MD (1) · Dokyun Kim, MD (1) · Douglas Denham, DO (1) · Erwin Blessing, MD (1) · Holger Reinecke, MD (1) · Jaeseung Shin, MD (1) · James Hampsey, MD (1) · Jeffrey W Olin, DO (1)
PMID 23389323, PMID 23647688, PMID 23759172, PMID 24395557, PMID 29281033, PMID 34088340