17 completed, 5 terminated, 5 withdrawn, 4 recruiting. 20 Phase 2, 10 Phase 3, 9 Phase 1, 3 Early Phase 1, 2 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Mixed Phenotype Acute Leukemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Withdrawn | Children's Oncology Group | 2026-09-10 | 2026-05-05 | |
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 153 | 2025-06-05 | 2026-10-21 |
| Intrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Receptor T-Cell-Associated Neurotoxicity Syndrome Biospecimen Collection, Cytarabine, Lumbar Puncture - Hematopoietic and Lymphatic System Neoplasm | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 26 | 2025-06-04 | 2026-06-26 |
| Role Of Sensitivity to neuroEndocrine Systems in Social Decisions Hydrocortisone, Yohimbine, Placebo - Borderline Personality Disorder | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2024-07-01 | 2024-06-05 | |
| Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia Chronocort, Cortef, Placebo - Congenital Adrenal Hyperplasia | Phase 3 | Completed | Neurocrine UK Limited | 55 | 2022-05-24 | 2026-10-02 |
| Corticosteroids to Treat Pancreatitis Hydrocortisone, Placebo - Pancreatitis, Pancreatitis, Acute | Phase 2 | Recruiting | Beth Israel Deaconess Medical Center | 86 | 2022-03-06 | 2026-02-18 |
| Epinephrine and Cortisol in Depression Hydrocortisone Acetate (CORT), Epinephrine Sulfate (EPI), Placebo (PLB) - Depression | Early Phase 1 | Withdrawn | Stanford University | 2020-12-01 | 2021-10-06 | |
| A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations Allogeneic Hematopoietic Stem Cell Transplantation, Asparaginase Erwinia chrysanthemi, Biospecimen Collection - Acute Myeloid Leukemia | Phase 3 | Recruiting | Children's Oncology Group | 1400 | 2020-07-21 | 2026-09-17 |
| Pevonedistat, Azacitidine, Fludarabine Phosphate, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Azacitidine, Cytarabine, Fludarabine Phosphate - Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Recurrent Acute Myeloid Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 2019-05-17 | 2025-04-13 |
| Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess Hydrocortisone - Hyperandrogenemia, Obesity | Early Phase 1 | Withdrawn | University of Virginia | 2018-01-19 | 2018-07-19 | |
| Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Calaspargase Pegol, Cyclophosphamide - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 352 | 2017-08-08 | 2026-10-05 |
| The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression Hydrocortisone acetate, Placebo - Depression | Early Phase 1 | Completed | Stanford University | 192 | 2016-07-01 | 2021-10-22 |
| Combination Chemotherapy, Rituximab, and Ixazomib Citrate in Treating Patients With Non-Hodgkin Lymphoma Cyclophosphamide, Cytarabine, Doxorubicin Hydrochloride - Adult Burkitt Lymphoma, B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma | Phase 1 / Phase 2 | Unknown | Northwestern University | 38 | 2015-10-28 | 2022-02-21 |
| Hydrocortisone for Prevention of Post-Traumatic Stress Disorder Hydrocortisone - Post-Traumatic Stress Disorder | Not applicable | Withdrawn | Albert Einstein Healthcare Network | 2015-02-02 | 2017-05-10 | |
| Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Asparaginase, Blinatumomab - Recurrent B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 669 | 2014-12-17 | 2026-10-21 |
| Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia Solu-Cortef, Cortef - Addison Disease, Adrenal Hyperplasia Congenital | Phase 1 / Phase 2 | Completed | Haukeland University Hospital | 8 | 2014-03-27 | 2024-06-07 |
| Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure Hydrocortisone - Addison Disease | Phase 2 | Unknown | Haukeland University Hospital | 20 | 2013-06-01 | 2013-12-02 |
| Continuous Subcutaneous Hydrocortisone Infusion In Addison's Disease and Type 1 Diabetes Cortef, Solu-cortef - Addison Disease, Type 1 Diabetes | Phase 2 | Terminated | Haukeland University Hospital | 4 | 2013-04-24 | 2024-03-01 |
| Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma dexamethasone, vincristine sulfate, rituximab - Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood B-Lymphoblastic Lymphoma | Phase 2 | Completed | St. Jude Children's Research Hospital | 80 | 2013-04-15 | 2022-09-28 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (6) · Prostatic Neoplasms (5) · Burkitt Lymphoma (4) · Leukemia, Biphenotypic, Acute (4) · Addison Disease (3) · Adrenal Hyperplasia, Congenital (3) · Depression (3) · Leukemia, Myeloid, Acute (3) · Anemia, Refractory (2) · Anemia, Refractory, with Excess of Blasts (2) · Leukemia (2) · Leukemia, Myelomonocytic, Chronic (2) · Lymphoma (2) · Lymphoma, B-Cell (2) · Lymphoma, Large B-Cell, Diffuse (2)
Children's Oncology Group (7) · National Cancer Institute (NCI) (7) · Haukeland University Hospital (3) · Stanford University (3) · Neurocrine UK Limited (2) · Academic and Community Cancer Research United (1) · Albert Einstein Healthcare Network (1) · Beth Israel Deaconess Medical Center (1) · Dana-Farber Cancer Institute (1) · Kent State University (1) · M.D. Anderson Cancer Center (1) · Northwestern University (1) · OHSU Knight Cancer Institute (1) · Roswell Park Cancer Institute (1) · St. Jude Children's Research Hospital (1)
United States (32) · Australia (7) · Canada (7) · Puerto Rico (7) · New Zealand (4) · Norway (3) · France (2) · Netherlands (2) · Switzerland (2) · Austria (1) · Belgium (1) · Chile (1) · Czechia (1) · Finland (1) · Germany (1)
Keith Sudheimer, Ph.D. (2) · Alan S. Gamis, MD, MPH (1) · Aminah Jatoi (1) · Andrea Biondi (1) · Barbara Pro, MD (1) · Ben K Watkins (1) · Beverly Lange (1) · Christine M. Burt Solorzano, MD (1) · Doulas L Delahanty, PhD (1) · Elizabeth Raetz, MD (1) · Erin H Breese (1) · Eystein Husebye, Professor (1) · Glenn Bubley, MD (1)
PMID 19029421, PMID 19304957, PMID 20056794, PMID 20413658, PMID 21849481, PMID 22392565, PMID 25667107, PMID 28419486, PMID 30957229, PMID 32414848, PMID 33651090, PMID 33843815, PMID 36815378, PMID 37172949, PMID 37257143, PMID 38107263, PMID 38237077, PMID 38295280, PMID 38431131, PMID 38947228, PMID 40568722, PMID 42085603, PMID 42497367
U10CA098543 (7), U10CA180886 (7), 2017 (1), P30CA015083 (1), P30CA016056 (1), P30CA016672 (1), P30CA060553 (1), R34MH073014 (1), UM1CA228823 (1)