7 completed, 2 recruiting, 2 unknown, 1 terminated. 12 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 7, Recruiting 2, Unknown 2, Terminated 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
Follow Clavulanic Acid: new trials by email Literature Review of Clavulanic Acid trials Research Report on Clavulanic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility - Urinary Tract Infections, Bacteremia | Phase 3 | Recruiting | Lund University | 330 | 2023-05-29 | 2023-08-28 |
| Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension trimethoprim-sulfamethoxazole (co-trimoxazole), amoxycillin/clavulanic acid and ciprofloxacin, Immunoglobulins - Haematological Malignancy, Hypogammaglobulinemia | Phase 2 / Phase 3 | Recruiting | Monash University | 300 | 2022-11-30 | 2024-04-19 |
| Perianal Abscess Recurrence and Fistula Formation: Antibiotics Following Incision and Drainage Trial Antibiotic 1 arm (amoxicillin + clavulanic acid), Antibiotic 2 arm (ciprofloxacin + metronidazole) - Perianal Abscess, Perianal Fistula | Phase 3 | Completed | Sunnybrook Health Sciences Centre | 15 | 2021-11-18 | 2026-01-12 |
| Azithromycin+Amoxicillin/Clavulanate vs Amoxicillin/Clavulanate in COVID19 Patients With Pneumonia in Non-intensive Unit Azithromycin with amoxicillin/clavulanate, amoxicillin/clavulanate - COVID-19 Pneumonia | Phase 3 | Unknown | Nantes University Hospital | 104 | 2020-04-30 | 2020-04-29 |
| Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract nitrofurantoin, No prophylaxis, Amoxicillin-Potassium Clavulanate Combination - Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1 | Phase 3 | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 292 | 2013-12-01 | 2023-09-28 |
| Concentration of Ampicillin / Sulbactam and Amoxicillin / Clavulanic Acid in the Blood During Renal Replacement Therapy in Longterm Renal Replacement Therapy Patients Administration of Amoxicillin / clavulanic acid, Ampicillin / sulbactam, Blooddraws for pharmacokinetic profiling - Infection During Hemodialysis | Phase 3 | Completed | Medical University of Vienna | 16 | 2013-08-01 | 2017-05-31 |
| Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis Lactobacillus salivarius HN6, Lactobacillus reuteri CR20, Lactobacillus fermentum LC40 - Mastitis | Phase 2 / Phase 3 | Completed | Universidad Complutense de Madrid | 300 | 2008-07-01 | 2009-05-25 |
| Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Metronidazole, Cefuroxime, Amoxicillin (+ clavulanic acid) and Fluconazole, Placebo - Acute Appendicitis, Perforated Gastroduodenal Ulcer | Phase 3 | Completed | The Faculty Hospital Na Bulovce | 187 | 2008-07-01 | 2012-02-08 |
| A Study to Assess the Efficacy and Safety of IV/PO Moxifloxacin in Subjects With Community-acquired Pneumonia Avelox (Moxifloxacin, BAY12-8039), Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin - Pneumonia | Phase 3 | Completed | Bayer | 60 | 2008-02-01 | 2014-11-04 |
| Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media levofloxacin; amoxicillin/clavulanate - Otitis Media | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 1643 | 2002-11-01 | 2011-01-10 |
| A Study of the Effectiveness and Safety of High Dose, Short-course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis. levofloxacin, azithromycin, amoxicillin/clavulanate - Bronchitis, Chronic Bronchitis | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 659 | 2001-11-01 | 2010-04-28 |
| Oral vs Initial Intravenous Antibiotic Treatment of Urinary Tract Infections in Children: a RCT oral amoxicilline/clavulanic acid, iv ceftriaxone - Urinary Tract Infections | Phase 3 | Terminated | University of Padova | 440 | 2000-06-01 | 2020-12-14 |
Urinary Tract Infections (2) · Agammaglobulinemia (1) · Appendicitis (1) · Bacteremia (1) · Breast Feeding (1) · Bronchitis (1) · Bronchitis, Chronic (1) · Community-Acquired Pneumonia (1) · Hematologic Neoplasms (1) · Infections (1) · Leukemia (1) · Lymphoma (1) · Mastitis (1) · Neoplasms (1) · Neoplasms, Plasma Cell (1)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · Bayer (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Lund University (1) · Medical University of Vienna (1) · Monash University (1) · Nantes University Hospital (1) · Sunnybrook Health Sciences Centre (1) · The Faculty Hospital Na Bulovce (1) · Universidad Complutense de Madrid (1) · University of Padova (1)
Italy (2) · Australia (1) · Austria (1) · Canada (1) · Czechia (1) · France (1) · Spain (1) · Sweden (1)
Aleksandra M Zurowska, Professor (1) · Antonella Toffolo, Dr (1) · Enrico Verrina, MD (1) · Esra Baskin, Professor (1) · Fatos Yalcinkaya, Professor (1) · Florian Thalhammer, Prof. MD (1) · Franz Schaefer, Professor (1) · Giovanni Montini, Dr (1) · Giovanni Montini, MD (1) · Graziella Zacchello, Professor (1) · Lutz T. Weber, Professor (1)
PMID 17261234, PMID 17611232, PMID 18762516, PMID 20455694, PMID 24880136, PMID 37660037, PMID 37702442