56 recruiting, 35 active not recruiting, 17 not yet recruiting, 15 completed. 150 Phase 2, 38 Phase 1, 3 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer Cemiplimab + Fianlimab [Fixed Dose Combination (FDC)] - Colon Cancer | Phase 2 | Not yet recruiting | John Strickler, M.D. | 24 | 2027-03-01 | 2026-11-05 |
| A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck Cemiplimab, Fianlimab, Carboplatin - Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | University of Chicago | 90 | 2027-02-07 | 2026-01-20 |
| Cemiplimab for Clinical Stage I, 2-3.9cm, Non-Small Cell Lung Cancer Cemiplimab, Pemetrexed (1), Cisplatin - Non-Small Cell Lung Cancer | Phase 2 | Not yet recruiting | Medical University of South Carolina | 38 | 2027-02-01 | 2026-11-10 |
| Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer Cemiplimab, Zanzalintinib - Anaplastic Thyroid Cancer | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 12 | 2027-01-31 | 2026-10-14 |
| Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 Cemiplimab, Adjuvant chemotherapy - Lung Cancer (NSCLC) | Phase 2 | Not yet recruiting | Henry Ford Health System | 33 | 2027-01-01 | 2026-07-15 |
| Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC) Cemiplimab - Colon and Rectal Cancer | Phase 2 | Recruiting | Columbia University | 20 | 2027-01-01 | 2026-11-04 |
| A Study Evaluating The Combination of Immunotherapy With Radiotherapy in Non-Small Cell Lung Cancer Investigator Choice Immunotherapy (for example: pembrolizumab, cemiplimab, durvalumab, ipilimumab plus nivolumab), Investigator Choice Chemotherapy (for example docetaxel with or without ramucirumab, gemcitabine, or other National Comprehensive Cancer Network (NCCN)-recommended treatments), Ablative Hypofractionated Radiotherapy - Non-Small Cell Lung Cancer, Metastatic Lung Cancer | Phase 2 | Recruiting | University of Chicago | 39 | 2026-12-12 | 2026-06-16 |
| Fianlimab&Cemiplimab as TotalNeoadj The (TNT) ForMelanoma Fianlimab, Cemiplimab - Melanoma (Skin) | Phase 2 | Not yet recruiting | University of California, Irvine | 35 | 2026-12-01 | 2026-09-11 |
| Cemiplimab for Kidney Transplant Recipients With Advanced Cutaneous Squamous Cell Carcinoma Cemiplimab, Prednisone, Sirolimus - Kidney Transplant Recipient, Cutaneous Squamous Cell Carcinoma (CSCC) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 22 | 2026-11-30 | 2026-10-15 |
| Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent Glioblastomas NeuroBlate® Laser Ablation Laser Interstitial Thermal Therapy, Cemiplimab, Chemotherapy - Glioblastoma, Glioblastoma, IDH-wildtype | Phase 2 | Not yet recruiting | Washington University School of Medicine | 99 | 2026-11-30 | 2026-10-20 |
| A Study Comparing Cemiplimab-based Treatments for Adult Participants With Locally Advanced Basal Cell Skin Cancer (laBCC) Cemiplimab, Vidutolimod, Fianlimab - Locally Advanced Basal Cell Carcinoma | Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 135 | 2026-11-13 | 2026-10-30 |
| RADICAL-IO: thRee Cycles of immunotherApy Without raDical Therapy In mediCALly InOperable Stage I Non-small Cell Lung Cancer Cemiplimab 350 mg IV - Non Small Cell Lung Cancer, Immunotherapy | Phase 2 | Not yet recruiting | The Netherlands Cancer Institute | 30 | 2026-11-01 | 2026-10-05 |
| Neoadjuvant PD-1 Inhibitor and EGFR Inhibitor in Locally Advanced Cutaneous Squamous Cell Carcinoma Cetuximab, Cemiplimab - Locally Advanced Cutaneous Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Melanoma and Skin Cancer Trials Limited | 27 | 2026-10-30 | 2026-10-07 |
| Adaptive Chemotherapy for Pd-l1 High REsEctablE NSCLC: A Chemo-PHREE Trial Cemiplimab - Nsclc, NSCLC Stage II | Phase 2 | Recruiting | University of Maryland, Baltimore | 30 | 2026-09-19 | 2026-11-04 |
| A Study of Radiation Therapy and Cemiplimab With or Without Fianlimab In People With Bladder Cancer Stereotactic body radiotherapy, Cemiplimab, Cemiplimab and Fianlimab - Bladder Urothelial Carcinoma | Phase 2 | Withdrawn | Memorial Sloan Kettering Cancer Center | 2026-09-01 | 2026-09-03 | |
| PROSECCO: A Phase 2, Single Arm, Neoadjuvant Study Evaluating Combination Cemiplimab, Fianlimab, And Ipilimumab In Patients With Surgically Resectable Melanoma Cemiplimab, Lpilimumab, Fianlimab - Melanoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 20 | 2026-09-01 | 2026-04-06 |
| Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma Biopsy Procedure, Biospecimen Collection, Carboplatin - Sinonasal Squamous Cell Carcinoma, Stage III Sinonasal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 108 | 2026-09-01 | 2026-10-05 |
| A Safety and Efficacy Study of Combined Fianlimab + Cemiplimab in Children and Young Adults With Recurrent or Progressive High-Grade Glioma or Posterior Fossa-A Ependymoma Cemiplimab, Cemiplimab+Fianlimab Fixed Dose Combination (FDC) - High-Grade Glioma (HGG), Posterior Fossa-A Ependymoma | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 120 | 2026-08-31 | 2026-05-05 |
| Immunotherapy Without Chemotherapy for Advanced Lung Cancer Patients With High PD-L1 Levels Pembrolizumab, Cemiplimab - Non Small Cell Lung Cancer (Squamous or Non Squamous) | Phase 2 | Recruiting | UNICANCER | 275 | 2026-08-21 | 2026-09-25 |
| Photoimmunotherapy With ASP-1929 and Cemiplimab for the Treatment of Refractory, Inoperable, and Metastatic Stage IIIB-IV Non-small Cell Lung Cancer Biospecimen Collection, Cemiplimab, Cetuximab Sarotalocan Sodium - Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma | Phase 2 | Withdrawn | Roswell Park Cancer Institute | 2026-08-15 | 2026-09-15 |
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Carcinoma, Non-Small-Cell Lung (37) · Neoplasms (16) · Melanoma (15) · Squamous Cell Carcinoma of Head and Neck (13) · Lung Neoplasms (12) · Neoplasm Metastasis (10) · Carcinoma, Renal Cell (8) · Head and Neck Neoplasms (7) · Recurrence (7) · Skin Neoplasms (7) · Carcinoma (6) · Carcinoma, Basal Cell (6) · Carcinoma, Squamous Cell (6) · Colonic Neoplasms (6) · Ovarian Neoplasms (6)
Regeneron Pharmaceuticals (27) · M.D. Anderson Cancer Center (9) · National Cancer Institute (NCI) (5) · Sanofi (5) · Memorial Sloan Kettering Cancer Center (4) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (4) · Columbia University (3) · University of Chicago (3) · BioNTech SE (2) · City of Hope Medical Center (2) · Duke University (2) · H. Lee Moffitt Cancer Center and Research Institute (2) · Hospital Israelita Albert Einstein (2) · ISA Pharmaceuticals (2) · Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest (2)
United States (113) · Spain (29) · France (26) · Italy (23) · Australia (19) · Germany (17) · South Korea (14) · Belgium (12) · Brazil (12) · Netherlands (11) · Taiwan (11) · Canada (10) · United Kingdom (9) · Turkey (Türkiye) (8) · Poland (7)
Eric Christenson, MD (2) · Ralf Gutzmer, Prof. Dr. med. (2) · Adanma Ayanambakkam, MD (1) · Ahmad Tarhini, MD, PHD (1) · Alexander Z Wei, MD (1) · Alfredo Berruti, Prof, MD (1) · Alice Bexon, MD (1) · Alison O'Neill, MD (1) · Annette M Lim, MBBS, FRACP, PhD (1) · Ari Rosenberg (1) · Arya Amini (1)
PMID 21796368, PMID 22198468, PMID 22623692, PMID 22649152, PMID 27406346, PMID 27406347, PMID 28851423, PMID 29863979, PMID 29950349, PMID 31585957, PMID 31952975, PMID 32031889, PMID 32053137, PMID 32450725, PMID 32554615, PMID 32701140, PMID 33477979, PMID 33768419, PMID 33929394, PMID 34000246, PMID 34187851, PMID 34413166, PMID 34529000, PMID 34741021, PMID 34850166, PMID 35058326, PMID 35065058, PMID 35623341, PMID 35993306, PMID 36069821, PMID 36094839, PMID 36456573, PMID 36821617, PMID 37029329, PMID 37315579, PMID 37325931, PMID 37505107, PMID 37839734, PMID 37875144, PMID 37922910, PMID 38072158, PMID 38086377, PMID 38180338, PMID 38252908, PMID 38449916, PMID 38471711, PMID 38745646, PMID 39031963, PMID 39073799, PMID 39158353
2023 (8), 2025 (6), 2017 (4), 2016 (2), 2018 (2), 2019 (2), P30CA033572 (2), UM1CA186691 (2), P01CA247886 (1), P30CA014089 (1), P30CA060553 (1), P30CA068485 (1), P30CA138292 (1), P50CA269011 (1), R44CA183075 (1)