22 completed, 5 recruiting, 4 not yet recruiting, 4 unknown. 22 Not applicable, 9 Phase 4, 4 Phase 2, 3 Phase 3.
Follow Bupivacaine 0.25%: new trials by email Literature Review of Bupivacaine 0.25% trials Research Report on Bupivacaine 0.25%
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Dexamethasone Versus Dexmedetomidine as Adjuvants in PENG Block in Hip Surgeries for Postoperative Pain Management Bupivacaine 0.25%, Dexamethasone, Dexmedetomidine - Postoperative Pain, Total Hip Arthroplasty (THA) | Phase 3 | Not yet recruiting | Assiut University | 90 | 2026-10-01 | 2026-09-29 |
| Parasternal Intercostal Nerve Block and Chronic Pain After Cardiac Surgery Ultrasound-Guided Parasternal Intercostal Nerve Block, Bupivacaine 0.25% - Chronic Postoperative Pain, Chronic Post-Sternotomy Pain | Not applicable | Not yet recruiting | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 132 | 2026-09-28 | 2026-09-30 |
| Analgesic Outcomes of Ultrasound-Guided QLB vs TAP Block in Midline Laparotomy Ultrasound-Guided Lateral Quadratus Lumborum Block (QL1), Ultrasound-Guided Transversus Abdominis Plane Block, Bupivacaine 0.25% - Postoperative Pain, Midline Laparotomy | Not applicable | Not yet recruiting | Sheikh Zayed Medical College | 100 | 2026-09-01 | 2026-09-01 |
| Combined SPSP and TTP Blocks for Postoperative Analgesia Post-CABG Transversus Thoracic Plane Block, Transversus Thoracic Plane (TTP) Block, Conventional Systemic Analgesia - Postoperative Pain Following Coronary Artery Bypass Grafting (CABG) | Not applicable | Enrolling by invitation | Ain Shams University | 88 | 2026-07-01 | 2026-06-22 |
| Intrapleural Bupivacaine Analgesia for Postoperative Pain Management After Minimally Invasive Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial Bupivacaine 0.125%, Bupivacaine 0.25%, Normal Saline - Pain Management | Phase 4 | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 249 | 2026-02-01 | 2026-02-06 |
| Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery. Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block - Posterior Fossa Tumor | Phase 3 | Recruiting | Children's Cancer Hospital Egypt 57357 | 260 | 2025-12-17 | 2026-10-16 |
| Cervical Erector Spinae Plane Block vs Cervical Plexus Block in Controlling Acute Postoperative Pain After Thyroidectomy Cervical erector spinae plane block, Cervical plexus block - Cervical, Erector Spinae Plane Block | Not applicable | Completed | Cairo University | 40 | 2025-05-15 | 2025-12-29 |
| Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy Tranexamic acid, caudal epidural block, Placebo - Intraoperative Blood Loss, Pediatric | Not applicable | Recruiting | Assiut University | 400 | 2025-04-03 | 2025-11-17 |
| Ultrasound-guided Multilevel Erectorspinae Plane Block Versus Thoracic Epidural Analgesia for Prevention of Post Mastectomy Pain Syndrome for Breast Cancer Patients Erector spinae plane block (ESPB), Thoracic epidural block - Ultrasound, Multilevel Erector Spinae Plane Block | Not applicable | Recruiting | National Cancer Institute, Egypt | 44 | 2025-03-20 | 2025-05-21 |
| Postoperative Pain Will be Compared in Cholecystectomy Patients: Half Receiving TAP Block and Half Without it. Bupivacaine 0.25%, Standard Post-Operative Care - Cholelithiasis, Pain, Postoperative | Not applicable | Completed | Darul Sehat Hospital | 60 | 2025-03-11 | 2026-03-13 |
| Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy Rectus sheath block, Intrathecal morphine - Ultrasound, Rectus Sheath Block | Not applicable | Completed | Ain Shams University | 80 | 2025-02-20 | 2026-08-12 |
| Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Postoperative Pain in Cancer Patients Undergoing Open Nephrectomy Intramuscular quadratus lumborum block, Lateral quadratus lumborum block, General anesthesia - Bilateral, Ultrasound | Not applicable | Recruiting | National Cancer Institute, Egypt | 90 | 2024-12-10 | 2025-03-21 |
| Cervical Retrolaminar Block Versus Cervical Epidural Injection for Cervical Radiculopathy Fluoroscopy-guided cervical interlaminar epidural injection, Cervical Retrolaminar Block, Bupivacaine 0.25% - Cervical Radiculopathy | Not applicable | Completed | Istanbul Medeniyet University | 70 | 2024-12-05 | 2025-12-11 |
| Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery Normal Saline (Placebo), Bupivacaine 0.25%, Dexmedetomidine - Post Operative Analgesia | Phase 3 | Recruiting | Al-Azhar University | 75 | 2024-12-01 | 2025-04-22 |
| Effect of Adding Dexamethasone to Bupivacaine 0.25% in SCPB on Surgical Field Visibility During Tympanomastoid Surgery bupivacaine 0.25%, dexamethasone 2 mg in bupivacaine 0.25% - Surgical Field, Postoperative Pain | Phase 4 | Unknown | Cairo University | 56 | 2024-05-15 | 2024-05-17 |
| Bupivacaine 0.125% Versus Bupivacaine 0.25% in Superficial Cervical Plexus Block for Tympanomastoid Surgeries in Adults bupivacaine 0.25%, bupivacaine 0.125% - Surgical Field, Acute Postoperative Pain | Phase 4 | Unknown | Cairo University | 60 | 2024-05-01 | 2024-05-07 |
| "Efficacy of Local Anesthetic for Postoperative Pain in Gynecologic Laparoscopy" Bupivacaine 0.25% - Gynecologic Laparoscopic Surgery, Postoperative Pain | Not applicable | Completed | Usama Ahmed Elsaeed Salem, MD | 90 | 2024-03-01 | 2025-06-22 |
| Fentanyl Vs Dexmedetomidine as Adjuvants to Bupivacaine in Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Arthroscopic Shoulder Surgeries Bupivacaine 0.25%, Bupivacaine 0.25% + Fentanyl 1µg/kg, Bupivacaine 0.25% + dexmedetomidine 1µg/kg - Fentanyl, Dexmedetomidine | Not applicable | Completed | Tanta University | 90 | 2024-01-01 | 2026-09-23 |
| Efficacy of Adding Dexmedetomidine in Ultrasound-guided Intermediate Cervical Plexus Block for Thyroidectomy Surgery dexmedetomidine, bupivacaine 0.25%, Thyroidectomy Surgery - Pain, Postoperative, Cancer of Larynx | Not applicable | Completed | National Cancer Institute, Egypt | 60 | 2023-04-01 | 2024-04-05 |
| Caudal Epidural Vs. TAP Block for Postoperative Analgesia in Pediatric Infraumbilical Surgery: a RCT Caudal Epidural Block, Transversus Abdominis Plane (TAP) Block, Bupivacaine 0.25% - Postoperative Pain, Pediatric Surgery | Not applicable | Completed | Namik Kemal University | 60 | 2022-12-15 | 2025-04-01 |
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Pain, Postoperative (21) · Agnosia (3) · Abdominal Pain (1) · Acute Pain (1) · Cholelithiasis (1) · Elbow Fractures (1) · Fractures, Bone (1) · Infratentorial Neoplasms (1) · Labor Pain (1) · Laryngeal Neoplasms (1) · Musculoskeletal Diseases (1) · Obesity, Morbid (1) · Osteoarthritis, Knee (1) · Radiculopathy (1) · Rotator Cuff Injuries (1)
Cairo University (4) · Ain Shams University (3) · Assiut University (3) · National Cancer Institute, Egypt (3) · Menoufia University (2) · Tanta University (2) · Abdelrady S Ibrahim, MD (1) · Al-Azhar University (1) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (1) · Bozyaka Training and Research Hospital (1) · Children's Cancer Hospital Egypt 57357 (1) · Coordinación de Investigación en Salud, Mexico (1) · Darul Sehat Hospital (1) · Hospital for Special Surgery, New York (1) · Istanbul Medeniyet University (1)
Egypt (19) · United States (7) · Turkey (Türkiye) (3) · Pakistan (2) · China (1) · Mexico (1) · Saudi Arabia (1)
Kareem MA Nawwar, M.D. (2) · Mohsen M Waheb, M.D. (2) · Abdul Sattar Narejo, FCPS (1) · Aboumazen A Abouhashem, M.B.B.Ch. (1) · Ali Shariat, MD (1) · Amr M Sleem, M.D. (1) · Brian M Ilfeld, MD,MS (1) · Christopher J Edwards, MD (1) · Fatma A Mohamed Hassan, M.B.B.Ch. (1) · Gehan A Trabeeh, MD (1) · Gehan M. Kamal, Prof. (1) · Ilse C Iparrea Ramos, Dr. (1)