229 completed, 43 unknown, 27 terminated, 11 withdrawn. 100 Phase 3, 89 Phase 2, 55 Phase 4, 35 Not applicable, 22 Phase 1.
Follow Botulinum Toxin Type A: new trials by email Literature Review of Botulinum Toxin Type A trials Research Report on Botulinum Toxin Type A
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Botulinum Toxin A Versus Nanofat in the Treatment of Androgenetic Alopecia: A Comparative Clinical Trial Botulinum Toxin Type A, Autologous Nanofat Injection - Androgenetic Alopecia | Phase 2 / Phase 3 | Not yet recruiting | Sherief Ayman Hussein Shaamash | 40 | 2026-12-01 | 2026-10-07 |
| Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy Botulinum Toxin Type A, Duloxetine, Oral Placebo Tablet - Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy | Phase 2 | Not yet recruiting | Assiut University | 56 | 2026-11-01 | 2026-10-20 |
| Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis Hyaluronic acid, Botulinum toxin type A - Intraarticular Injection, Botox | Not applicable | Recruiting | Tanta University | 50 | 2026-06-24 | 2026-06-25 |
| Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides Botulinum toxin type A - Wrinkle, Glabellar Frown Lines | Phase 4 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 325 | 2026-02-02 | 2026-08-14 |
| Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain Botulinum toxin type A, Saline (0.9% NaCl) - Hemorrhoids, Postoperative Pain | Phase 2 | Recruiting | Lomonosov Moscow State University Medical Research and Educational Center | 292 | 2026-02-01 | 2026-03-10 |
| Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study Botulinum toxin type A, Hyaluronic acid - Premature Ejaculation | Not applicable | Not yet recruiting | Benha University | 80 | 2025-12-15 | 2025-11-19 |
| Botulinum Toxin Type A for Frontal Hyperhidrosis Botulinum Toxin Type A - Primary Frontal Hyperhidrosis | Not applicable | Recruiting | Latakia University | 30 | 2025-11-20 | 2026-05-01 |
| Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine Sphenopalatine block, Botulinum Toxin Type A - Sphenopalatine Block, BOTOX | Not applicable | Recruiting | Cairo University | 64 | 2025-05-15 | 2025-05-16 |
| Botulinum Toxin-A for Hidradenitis Suppurativa Normal saline, Botulinum toxin type A - Hidradenitis Suppurativa, Hidradenitis Suppurativa \(HS\) | Phase 4 | Withdrawn | Yale University | 2025-01-01 | 2025-12-16 | |
| Efficacy of Focused Shock Wave Therapy Before and After Botulinum Toxin Injection in Patients With Post-Stroke Spastic Equinus/Equinovarus Foot: A Randomized Clinical Trial Botulinum toxin type A, Focal Extracorporeal Shock Wave Therapy (ESWT) - Post-Stroke Spasticity, Spastic Equinovarus Foot | Not applicable | Active not recruiting | María Belén Martínez Luna | 69 | 2024-10-10 | 2026-08-11 |
| Botulinum Toxin Injection in the UES for R-CPD botulinum toxin type A, Sodium Chloride 0.9% Inj - Retrograde Cricopharyngeus Dysfunction | Phase 4 | Active not recruiting | AZ Delta | 50 | 2024-09-02 | 2025-12-08 |
| Comparative Study of the Effects of Dry Needling and Botulinum Toxin Type A as a Treatment for Lower Limb Post-stroke Spasticity Botulinum toxin type A, Dry Needling - Stroke | Phase 2 / Phase 3 | Recruiting | Universiteit Antwerpen | 90 | 2024-09-01 | 2026-05-04 |
| Assessing the Impact of Botulinum Toxin Type A on Facial Wrinkles: A Comprehensive Clinical Investigation Botulinum toxin type A - Wrinkle | Withdrawn | Global Aesthetics LLC | 2024-05-22 | 2026-08-12 | ||
| Ultrasound-guided Botulinum Toxin Injection on Cricopharyngeal Muscle Dysfunction botulinum toxin type A, Injection - Cricopharyngeal Achalasia | Not applicable | Unknown | Copka Sonpashan | 30 | 2024-03-01 | 2024-03-25 |
| A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines BOTOX - Upper Facial Lines | Phase 4 | Completed | AbbVie | 100 | 2024-02-05 | 2025-11-24 |
| Fractional Co2 Laser Versus Microbotox Injection in the Treatment of Wide Facial Pores: A Split Face Comparative Study microbotox, fractional carbon dioxide laser - Skin Abnormalities | Phase 1 | Unknown | Assiut University | 21 | 2024-02-01 | 2023-12-27 |
| Study of Intramuscular Injections of ABBV-950 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Spasticity ABBV-950, BOTOX, Placebo for ABBV-950 - Upper Limb Spasticity | Phase 1 | Terminated | AbbVie | 1 | 2024-01-12 | 2024-07-01 |
| Use of Botulinum Toxin A in Direct Eyebrow Lift Scar Botulinum toxin type A - Skin Scarring, Eyebrow Ptosis | Phase 2 | Unknown | University of Sao Paulo | 40 | 2024-01-01 | 2024-06-18 |
| A Study to Assess the Adverse Events and Effectiveness of BOTOX Injections for the Treatment of Moderate to Severe Forehead Lines in Chinese Adult Participants BOTOX, Placebo - Forehead Lines | Phase 3 | Completed | AbbVie | 140 | 2023-12-12 | 2025-08-28 |
| Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A Botulinum toxin type A, Isotonic saline 0,9% - Temporomandibular Disorders | Phase 2 | Recruiting | Karolinska Institutet | 100 | 2023-11-14 | 2026-08-05 |
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Muscle Spasticity (36) · Stroke (23) · Migraine Disorders (18) · Urinary Bladder, Overactive (18) · Cerebral Palsy (17) · Torticollis (16) · Urinary Incontinence (16) · Cicatrix (9) · Hyperhidrosis (8) · Neuralgia (7) · Headache (5) · Myofascial Pain Syndromes (5) · Pain (5) · Chronic Pain (4) · Parkinson Disease (4)
Allergan (79) · Ipsen (46) · Revance Therapeutics, Inc. (9) · AbbVie (8) · Medy-Tox (7) · Norwegian University of Science and Technology (7) · Cairo University (6) · Chang Gung Memorial Hospital (6) · Kocaeli University (5) · GlaxoSmithKline (4) · Galderma R&D (3) · Mayo Clinic (3) · Mentor Worldwide, LLC (3) · Western University, Canada (3) · AZ Delta (2)
United States (129) · Canada (48) · Germany (36) · Poland (34) · South Korea (32) · France (31) · Czechia (30) · United Kingdom (29) · Belgium (24) · Italy (23) · Russia (23) · Turkey (Türkiye) (20) · Spain (19) · China (16) · Australia (15)
Mandar Jog, MD (3) · Nigar Dursun, MD (3) · Pong Ya-Ping, MD (3) · Arlene Lum (2) · Corey Maas, MD (2) · Dana Fetterolf (2) · Emily McCusker (2) · Erling A Tronvik, PhD, MD (2)
PMID 20359934, PMID 20487038, PMID 21883197, PMID 24754838, PMID 25080874, PMID 25324317, PMID 25500317, PMID 26231052, PMID 29093068, PMID 29781237, PMID 31112399, PMID 32108436, PMID 32665528, PMID 32741133, PMID 33026630, PMID 33026631, PMID 33206382, PMID 33955921, PMID 35400537, PMID 36206385, PMID 10896696, PMID 12145388, PMID 12893330, PMID 12907905, PMID 1448532, PMID 16400513, PMID 16651948, PMID 16777777, PMID 16901024, PMID 18468272, PMID 18634953, PMID 18844269, PMID 19289689, PMID 19357910, PMID 20111849, PMID 21368663, PMID 21757278, PMID 22021883, PMID 22092807, PMID 22371239, PMID 22464310, PMID 22673486, PMID 23092904, PMID 23098762, PMID 23123438, PMID 23444480, PMID 23604344, PMID 23608668, PMID 25158709, PMID 25541942
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