23 completed, 13 terminated, 3 withdrawn, 2 recruiting. 30 Phase 2, 12 Phase 1, 7 Phase 3, 5 Not applicable.
Follow Bone Marrow Transplant: new trials by email Literature Review of Bone Marrow Transplant trials Research Report on Bone Marrow Transplant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Aplastic Anemia | Phase 2 | Active not recruiting | Fred Hutchinson Cancer Center | 1 | 2025-09-25 | 2026-05-22 |
| Delayed Tolerance Through Mixed Chimerism Bone Marrow Transplant, Peripheral Blood Stem Cell Collection, Fludarabine - Kidney Failure, Kidney Transplant; Complications | Phase 1 / Phase 2 | Recruiting | Massachusetts General Hospital | 20 | 2023-10-01 | 2026-09-28 |
| CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies CliniMACS, Bone Marrow Transplant, Hyperfractionated Total Body Irradiation - Hematologic Diseases, Hematologic Malignancy | Phase 2 | Withdrawn | Baptist Health South Florida | 2022-09-01 | 2022-09-27 | |
| Cryopreserved MMUD BM With PTCy for Hematologic Malignancies Cyclophosphamide, Fludarabine, Total Body Irradiation - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 | Withdrawn | Ossium Health, Inc. | 2022-09-01 | 2026-02-24 | |
| HIV Antigen-specific T-cells Targeting Conserved Epitopes (HST-NEETs) BMTCTN1903 HST-NEETs, Bone Marrow Transplant - HIV Associated Lymphoma | Phase 2 | Completed | Catherine Bollard | 12 | 2021-10-25 | 2026-06-29 |
| Autologous Stem Cell Transplant for Crohn's Disease Autologous stem cell transplant, Cyclophosphamide, Thymoglobulin - Crohn Disease | Phase 2 | Recruiting | Aaron Etra | 50 | 2018-02-22 | 2026-07-24 |
| HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell Disease bone marrow transplant - Sickle Cell Disease | Phase 2 | Completed | Centre Hospitalier Intercommunal Creteil | 25 | 2017-08-10 | 2025-09-02 |
| Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplant (HSCT) For Lymphoma Allogeneic stem cell transplantation, Fludarabine, Thiotepa - Lymphoma | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2017-05-01 | 2017-03-22 | |
| Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia Failing TKIs Therapy Bosutinib, Bone Marrow Transplant, Bone Marrow cells - Leukemia, Myelogenous | Phase 2 | Completed | University of Milano Bicocca | 2 | 2015-11-01 | 2020-11-05 |
| Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia Bone Marrow Transplantation, Cyclophosphamide, Fludarabine Phosphate - Adult Acute Lymphoblastic Leukemia in Complete Remission, Acute Myeloid Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 31 | 2015-06-25 | 2025-06-22 |
| Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia Bone marrow transplant, Thymoglobulin, Fludarabine - Severe Aplastic Anemia, Bone Marrow Failure Syndromes | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 18 | 2014-08-01 | 2023-03-10 |
| Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation, Cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 54 | 2014-04-22 | 2024-01-24 |
| BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance anti-thymocyte globulin, Fludarabine, Cyclophosphamide - Kidney Transplantation | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 4 | 2014-01-07 | 2018-09-24 |
| Consolidation Therapy for Acute Myeloid Leukemia Guided by Leukemia Stem Cell Behavior Cytarabine consolidation, Allogeneic transplant - Acute Myeloid Leukemia | Phase 2 / Phase 3 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 10 | 2013-12-01 | 2018-08-14 |
| Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors Allogeneic HCT, Donor NK Cell Infusion - Ewing Sarcoma, Neuroblastoma | Phase 2 | Terminated | Monica Thakar | 15 | 2013-03-20 | 2025-03-19 |
| Sorafenib Tosylate Before and After Donor Bone Marrow Transplant in Treating Patients With Acute Myeloid Leukemia Bone Marrow Transplantation, Sorafenib, Sorafenib Tosylate - Acute Myeloid Leukemia With FLT3/ITD Mutation | Phase 1 | Completed | National Cancer Institute (NCI) | 51 | 2012-01-13 | 2024-04-02 |
| Infusion of Allogeneic CD19-Specific T Cells From Peripheral Blood HSCT, DLI - Leukemia, Lymphoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 95 | 2011-12-01 | 2025-03-13 |
| Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Fludarabine, Clofarabine, Busulfan - Disorder Related to Bone Marrow Transplantation, Leukemia | Phase 3 | Completed | M.D. Anderson Cancer Center | 256 | 2011-11-02 | 2021-12-16 |
| Shorter Course Tacrolimus After Nonmyeloablative, Related Donor BMT With High-dose Posttransplantation Cyclophosphamide Cyclophosphamide, Fludarabine, Total body irradiation - Hodgkin's Lymphoma, Leukemia | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 127 | 2011-08-01 | 2018-10-17 |
| Bone Marrow Transplant Trial for Patients With Refractory Severe Aplastic Anemia Bone Marrow Transplant - Severe Aplastic Anemia | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 4 | 2011-06-01 | 2016-10-13 |
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Leukemia (10) · Leukemia, Myeloid, Acute (9) · Myelodysplastic Syndromes (9) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (6) · Anemia, Aplastic (5) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (5) · Lymphoma (5) · Multiple Myeloma (5) · Anemia, Sickle Cell (3) · Graft vs Host Disease (3) · Hematologic Diseases (3) · Lymphoma, Non-Hodgkin (3) · Bone Marrow Failure Disorders (2) · Brain Neoplasms (2) · Central Nervous System Neoplasms (2)
Masonic Cancer Center, University of Minnesota (12) · M.D. Anderson Cancer Center (5) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (4) · Fred Hutchinson Cancer Center (2) · Massachusetts General Hospital (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Aaron Etra (1) · Baptist Health South Florida (1) · Catherine Bollard (1) · Centre Hospitalier Intercommunal Creteil (1) · Christopher Dvorak (1) · City of Hope Medical Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Medical College of Wisconsin (1) · Monica Thakar (1)
United States (41) · France (1) · Italy (1)
Paul Orchard, MD (3) · Margaret MacMillan, MD (2) · Richard E. Champlin, MD (2) · Aaron Etra, MD (1) · Alan Gamis (1) · Amy DeZern, MD (1) · Amy Dezern, MD (1) · Angela Smith, MD (1) · Carlo Gambacorti-Passerini, MD (1) · Catherine M. Verfaillie, MD (1) · Christopher Dvorak, MD (1) · Claudio Brunstein, MD, PhD (1) · Daniel M Sullivan, MD (1) · Daniel Weisdorf (1) · Edward Ball (1)
PMID 19179301, PMID 20383216, PMID 20818854, PMID 20946966, PMID 21403127, PMID 21586746, PMID 22430088, PMID 22829629, PMID 25824692, PMID 27482888, PMID 27625358, PMID 29353109, PMID 31401903, PMID 32343796, PMID 34312462, PMID 36240296, PMID 36402456, PMID 37877375
P01CA015396 (1), P01CA049639 (1), P30CA006973 (1), P50CA100632 (1), U01CA070095 (1), U01HL069294 (1), U01HL069301 (1), U10HL069294 (1), U24CA076518 (1), UM1CA186691 (1)