7 completed, 2 terminated, 1 recruiting. 10 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 7, Terminated 2, Recruiting 1 |
| Phase 1 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Repurposing Atovaquone for the Treatment of Platinum-Resistant Ovarian Cancer Atovaquone, Biopsy, Computed Tomography - Ovarian High Grade Serous Adenocarcinoma, Platinum-Resistant Ovarian Carcinoma | Phase 2 | Recruiting | Emory University | 28 | 2023-11-09 | 2026-10-01 |
| Atovaquone for Treatment of COVID-19 Experimental Group, Placebo Group - COVID-19 | Phase 2 | Completed | University of Texas Southwestern Medical Center | 60 | 2020-07-22 | 2021-12-14 |
| Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection Atovaquone/Azithromycin - Covid19 | Phase 2 | Terminated | HonorHealth Research Institute | 3 | 2020-04-20 | 2026-06-29 |
| Sevuparin/DF02 as an Adjunctive Therapy in Subjects Affected With Uncomplicated Falciparum Malaria Sevuparin sodium + atovaquone/proquanil, atovaquone/proquanil - Malaria, Falciparum | Phase 1 / Phase 2 | Terminated | Modus Therapeutics AB | 53 | 2011-09-01 | 2014-08-19 |
| Weekly Dosing of Malarone ® for Prevention of Malaria Atovaquone Proguanil, Procedure - malaria challenge - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 35 | 2009-09-01 | 2013-11-25 |
| Safety and Efficacy Study of IV Artesunate to Treat Malaria Artesunate, Malarone - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 30 | 2006-03-01 | 2019-10-01 |
| A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children Azithromycin, Atovaquone, Sulfamethoxazole-Trimethoprim - Bacterial Infections, Pneumonia, Pneumocystis Carinii | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 690 | 2021-11-04 | |
| Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Sulfadiazine, Clarithromycin, Atovaquone - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 100 | 2021-10-28 | |
| A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Atovaquone, Sulfamethoxazole-Trimethoprim - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 300 | 2011-03-01 | |
| A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole Atovaquone, Pentamidine isethionate - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 2 | Completed | Glaxo Wellcome | 2005-06-24 |
Acquired Immunodeficiency Syndrome (4) · HIV Infections (4) · Pneumonia, Pneumocystis (3) · COVID-19 (2) · Malaria (2) · AIDS-Related Complex (1) · AIDS-Related Opportunistic Infections (1) · Bacterial Infections (1) · Encephalitis (1) · Malaria, Falciparum (1) · Toxoplasmosis, Cerebral (1)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · U.S. Army Medical Research and Development Command (2) · Emory University (1) · Glaxo Wellcome (1) · HonorHealth Research Institute (1) · Modus Therapeutics AB (1) · University of Texas Southwestern Medical Center (1)
United States (8) · Puerto Rico (2) · Belgium (1) · Canada (1) · France (1) · Germany (1) · Kenya (1) · Netherlands (1) · Thailand (1) · United Kingdom (1)
Amneris Luque, M.D. (1) · Anna Leitgeb, PhD (1) · Chirgwin K (1) · Ezimamaka Ajufo, M.D. (1) · Gregory Deye, MD (1) · Helen King, M.D. (1) · Hesham Sadek, M.D. (1) · Hughes WT (1) · James De Lemos, M.D. (1) · Jessica Meisner, M.D. (1) · John Schoggins, Ph.D. (1) · Luft B (1) · Mamta Jain, M.D. (1) · Michael Gordon, MD (1) · Namita Khanna, MD, MSPH (1)
P30CA138292 (1)