10 completed, 7 unknown, 4 not yet recruiting, 3 recruiting. 14 Not applicable, 4 Phase 3, 4 Phase 4, 1 Phase 2.
Follow Antibiotic Prophylaxis: new trials by email Literature Review of Antibiotic Prophylaxis trials Research Report on Antibiotic Prophylaxis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immunoglobulin Replacement Therapy (IgRT) Versus Antibiotic Prophylaxis (PA) in Patients Treated by CD19-targeted Chimeric Antigen Receptor (CAR)T Cells for a B Cell Acute Lymphoblastic Leukemia or a B Cell Lymphoma Immunoglobulin, antibiotic prophylaxis - Chimeric Antigen Receptor T-cell Therapy, B Cell Acute Lymphoblastic Leukemia (B-ALL) | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 228 | 2026-09-01 | 2026-08-10 |
| A Study Comparing Infectious Complications After Transperineal Prostate Biopsy With or Without Antibiotic Prophylaxis No antibiotic prophylaxis for prostate biopsy, Antibiotic prophylaxis (fosfomycin-trometamol) for prostate biopsy. - Infectious Complications Following Prostate Biopsy, Prostate Cancer | Not applicable | Enrolling by invitation | F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica | 300 | 2026-04-01 | 2026-05-15 |
| Randomized Controlled Trial of Different Antibiotic Duration Prior to Prostate Enucleation Surgery antibiotic prophylaxis - BPH With Urinary Obstruction, Antibiotic Prophylaxis | Phase 3 | Not yet recruiting | Ohio State University | 250 | 2026-01-01 | 2025-10-06 |
| Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser - Periodontitis | Not applicable | Recruiting | National and Kapodistrian University of Athens | 75 | 2025-08-25 | 2025-09-04 |
| TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden Tailored antibiotic and steroid therapy based on the IL-6 value in amniotic fluid obtained by amniocentesis in patients with premature rupture of membranes, Antenatal steroids administration, Neuroprotection - Preterm Premature Rupture of Membranes (PPROM) | Phase 3 | Recruiting | The Central and Eastern European Gynecologic Oncology Group | 138 | 2025-05-01 | 2026-06-18 |
| Prevelance, Predictors and Outcome of Sepsis Associated Liver Injury (SALI) Antibiotic - Liver Injuries | Not yet recruiting | Assiut University | 100 | 2025-04-01 | 2025-01-06 | |
| Is Methenamine Prophylaxis for Urinary Tract Infection After Midurethral Sling as Effective as Antibiotic Prophylaxis? Methenamine Hippurate 1g BD, Antibiotic prophylaxis - Urinary Tract Infection (Diagnosis) | Not applicable | Recruiting | Atlantic Health System | 190 | 2025-01-30 | 2025-02-07 |
| Antibiotic Prophylaxis for EUS-FNA of Pancreatic Cystic Lesions EUS-FNA, ATBp - Pancreatic Cystic Lesion | Not yet recruiting | Société Française d'Endoscopie Digestive | 1702 | 2024-09-15 | 2024-08-02 | |
| Antibiotic Prophylaxis to Prevent Post-procedure UTI After VCUG Antibiotic Prophylaxis, Placebo - Antibiotic Prophylaxis, Voiding Cystourethrogram | Phase 4 | Unknown | Hamilton Health Sciences Corporation | 84 | 2023-10-01 | 2023-04-12 |
| PROcalcitonin and Presepsin-guided Decision for Antibiotic Prophylaxis of EOS Procalcitonin/Presepsin guided antibiotic prophylaxis for EOS, Antibiotic prophylaxis for EOS - Early-Onset Neonatal Sepsis | Not applicable | Unknown | University of Florence | 266 | 2023-04-01 | 2023-04-03 |
| Prophylactic Antibiotic Administration for Bladder OnabotulinumtoxinA Injection Single-Dose Antibiotic, Multi-Dose Antibiotic - Overactive Bladder, Overactive Bladder Syndrome | Phase 4 | Completed | The Cleveland Clinic | 100 | 2022-12-06 | 2024-01-02 |
| The Effect of Pre-operative Single Dose Antibiotic Prophylaxis on the Post-operative Implant Success Dental implant placement, Antibiotic prophylaxis, Placebo - Tooth Loss | Not applicable | Unknown | Biruni University | 50 | 2022-09-01 | 2023-08-30 |
| Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT) Standard of care without prophylaxis, Antibiotic prophylaxis - Out-Of-Hospital Cardiac Arrest, Pneumonia | Phase 2 | Terminated | David J. Gagnon | 53 | 2021-08-20 | 2025-04-17 |
| PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2 Transperineal MRI-guided prostate biopsy, Transrectal MRI-guided prostate biopsy, Antibiotic (prophylaxis) - Infection | Not applicable | Completed | Weill Medical College of Cornell University | 1040 | 2021-06-24 | 2026-08-24 |
| Antibiotic Prophylaxis in Percutaneous Nephrostomy Placements and Replacements for Malignant Urinary Tract Obstruction antibiotic prophylaxis - Ureteral Obstruction, Neoplasms | Completed | Barretos Cancer Hospital | 320 | 2021-04-02 | 2026-05-19 | |
| Pre-operative Versus Post-operative Vaginal Cleansing With Chlorhexidine Solution in Prevention Post-Cesarean Section Infection Chlorhexidine - Post Cesarean Infectious Morbidity | Not applicable | Completed | Federal Teaching Hospital Abakaliki | 120 | 2021-04-01 | 2023-12-19 |
| PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy Transperineal MRI-guided prostate biopsy, Transrectal MRI-guided prostate biopsy, Antibiotic (prophylaxis) - Infection | Not applicable | Completed | Weill Medical College of Cornell University | 687 | 2021-03-22 | 2025-04-15 |
| Transperineal MRI-TRUS Fusion Guided Prostate Biopsy With vs Without Antibiotic Prophylaxis Transperineal prostate biopsy with or without antibiotic prophylaxis - Prostate Biopsy, Antibiotic | Not applicable | Completed | Oslo University Hospital | 550 | 2019-11-11 | 2021-12-07 |
| The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery. Antibiotics - Surgical Site Infection, Antibiotic Prophylaxis | Withdrawn | Yale University | 2019-06-01 | 2022-07-25 | ||
| Prophylaxis of Surgical Wound Infection With Topical Antibiotics Topical antibiotic prophylaxis - Surgical Site Infection, Surgery--Complications | Not applicable | Unknown | Hospital de Granollers | 560 | 2018-12-27 | 2023-04-13 |
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Infections (5) · Prostatic Neoplasms (5) · Urinary Tract Infections (4) · Surgical Wound Infection (2) · Acute Kidney Injury (1) · Bacteremia (1) · Burkitt Lymphoma (1) · Cholangitis (1) · Disease (1) · Endometritis (1) · Heart Arrest (1) · Hernia, Abdominal (1) · Inflammation (1) · Klatskin Tumor (1) · Lymphoma, B-Cell (1)
Weill Medical College of Cornell University (2) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Atlantic Health System (1) · Barretos Cancer Hospital (1) · Biruni University (1) · CAMC Health System (1) · Centre Hospitalier Universitaire de la Réunion (1) · David J. Gagnon (1) · Egyptian Biomedical Research Network (1) · F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica (1) · Federal Teaching Hospital Abakaliki (1) · Hadassah Medical Organization (1) · Hamilton Health Sciences Corporation (1) · Hospital de Granollers (1)
United States (8) · France (3) · Brazil (1) · Canada (1) · Czechia (1) · Germany (1) · Greece (1) · Israel (1) · Nigeria (1) · Norway (1) · Saudi Arabia (1) · Slovakia (1) · South Korea (1) · Spain (1) · Turkey (Türkiye) (1)
Jim C Hu, MD MPH (2) · Alaa El Ghoneimi, MD (1) · Andrew Vickers, PhD (1) · David Gagnon, PharmD (1) · Eduard Baco, MD, PhD (1) · Emily Slopnick, MD (1) · Eric Dobremez, MD (1) · Erik Rud, MD,PhD (1) · Felipe Ojeda, PhD (1) · Georges Audry, MD (1) · Jean Michel Guys, MD (1)
PMID 15765442, PMID 15966875, PMID 21704808, PMID 28243046, PMID 28898917, PMID 30132694, PMID 31065897, PMID 31972236, PMID 32011025, PMID 32383274, PMID 32674699, PMID 33865797, PMID 34563412, PMID 35054378, PMID 35839791, PMID 37208135, PMID 37296040, PMID 37713527, PMID 38679416, PMID 39115122, PMID 39472200, PMID 40630527, PMID 40885534, PMID 41159585, PMID 41298852, PMID 42238679
P20GM139745 (1), R01CA241758 (1)