27 recruiting, 25 active not recruiting, 23 completed, 5 not yet recruiting. 40 Phase 2, 31 Phase 1, 25 Phase 3, 3 Not applicable, 3 Phase 4.
Follow 5 Fluorouracil: new trials by email Literature Review of 5 Fluorouracil trials Research Report on 5 Fluorouracil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Not yet recruiting | Northwestern University | 125 | 2027-02-03 | 2026-08-06 |
| Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma Biospecimen Collection, Echocardiography Test, Fluorouracil - Childhood Posterior Fossa Ependymoma | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 70 | 2026-12-11 | 2026-09-30 |
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer Biospecimen Collection, Computed Tomography, Dynamic Contrast-Enhanced Magnetic Resonance Imaging - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-10-01 | 2026-10-05 |
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| A Study to Compare the Efficacy and Safety of YL201 With Standard Chemotherapy in Patients With Metastatic Pancreatic Cancer After Failure of Gemcitabine-Based Systemic Chemotherapy Tambotatug pelitecan, Liposomal irinotecan, 5 Fluorouracil - Metastatic Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 3 | Not yet recruiting | MediLink Therapeutics (Suzhou) Co., Ltd. | 320 | 2026-10-01 | 2026-09-04 |
| Microneedling Alone Versus Microneedling Coupled With Either Bleomycin or 5flourouracil in the Treatment of Plantar Warts Bleomycin, Microneedling alone, 5 fluorouracil - Warts of Foot | Not applicable | Not yet recruiting | Assiut University | 60 | 2026-06-01 | 2025-06-27 |
| AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients With Borderline Resectable, Locally Advanced or Metastatic Cholangiocarcinoma or Pancreatic Cancer Biopsy Procedure, Cisplatin, Computed Tomography - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Locally Advanced Cholangiocarcinoma | Phase 1 | Recruiting | Jonsson Comprehensive Cancer Center | 46 | 2026-05-29 | 2026-08-20 |
| Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations Biospecimen Collection, Computed Tomography, Fluorouracil - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 94 | 2026-05-13 | 2026-05-22 |
| Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy Biospecimen Collection, Capecitabine, Diltiazem Hydrochloride - Malignant Digestive System Neoplasm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-04-30 | 2026-06-02 |
| NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial Biospecimen Collection, Computed Tomography, Fluorouracil - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 20 | 2026-03-02 | 2026-09-21 |
| Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 35 | 2026-02-16 | 2026-08-19 |
| Neoadjuvant Therapy for the Treatment of Gastroesophageal Junction and Gastric Cancers Capecitabine, Docetaxel, Fluorouracil - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage II Gastric Cancer AJCC v8 | Phase 1 | Withdrawn | Ohio State University Comprehensive Cancer Center | 2025-12-31 | 2025-02-07 | |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-08-18 |
| Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Capecitabine - Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 356 | 2025-08-21 | 2026-08-25 |
| Study of NALIRIFOX in Advanced Unresectable Small Bowel Tumors Nanoliposomal irinotecan, Oxaliplatin, 5 fluorouracil - Small Bowel Adenocarcinoma | Phase 2 | Recruiting | Tiago Biachi de Castria | 36 | 2025-06-30 | 2026-07-28 |
| Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Colorectal Adenocarcinoma, Stage III Colorectal Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 24 | 2025-06-23 | 2026-09-09 |
| Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial Biospecimen Collection, Cisplatin, Computed Tomography - Non-Muscle Invasive Bladder Urothelial Carcinoma, Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 160 | 2025-06-03 | 2026-10-19 |
| FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery Balstilimab, Biospecimen Collection, Botensilimab - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 26 | 2025-05-20 | 2026-06-29 |
| Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer Abemaciclib, Biopsy Procedure, Biospecimen Collection - Metastatic Microsatellite Stable Colorectal Carcinoma, Refractory Microsatellite Stable Colorectal Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 39 | 2025-04-18 | 2026-10-15 |
Showing 20 of 91. Sign in to see all of them.
Colorectal Neoplasms (19) · Pancreatic Neoplasms (15) · Rectal Neoplasms (8) · Neoplasm Metastasis (6) · Adenocarcinoma Of Esophagus (5) · Colonic Neoplasms (5) · Stomach Neoplasms (5) · Neoplasms (4) · Ovarian Neoplasms (4) · Squamous Cell Carcinoma of Head and Neck (4) · Urinary Bladder Neoplasms (4) · Anus Neoplasms (3) · Adenocarcinoma (2) · Appendiceal Neoplasms (2) · Cholangiocarcinoma (2)
National Cancer Institute (NCI) (21) · M.D. Anderson Cancer Center (8) · City of Hope Medical Center (5) · ECOG-ACRIN Cancer Research Group (5) · Mayo Clinic (4) · NRG Oncology (4) · Children's Oncology Group (3) · Jonsson Comprehensive Cancer Center (3) · Roswell Park Cancer Institute (3) · Northwestern University (2) · OHSU Knight Cancer Institute (2) · Ohio State University Comprehensive Cancer Center (2) · SWOG Cancer Research Network (2) · Academic and Community Cancer Research United (1) · Al-Azhar University (1)
United States (75) · Canada (10) · Puerto Rico (9) · Australia (8) · France (4) · South Africa (4) · Taiwan (4) · Brazil (3) · Germany (3) · Singapore (3) · Spain (3) · Argentina (2) · Belgium (2) · China (2) · Czechia (2)
Christos Fountzilas (2) · Marwan G Fakih (2) · Steven H Lin (2) · Adam J Esbenshade (1) · Al B Benson (1) · Ann Raldow (1) · Anne M Noonan, MBBChBAO, MSc (1) · Ardaman Shergill (1) · Arjun Mittra, MD (1) · Ashwin Somasundaram, MD (1)
PMID 21997132, PMID 23233715, PMID 23358972, PMID 26615328, PMID 28006055, PMID 30080723, PMID 30414528, PMID 30525443, PMID 30654298, PMID 30842038, PMID 30975630, PMID 31203498, PMID 31268130, PMID 31553639, PMID 31618129, PMID 31657981, PMID 31789476, PMID 31811950, PMID 31856081, PMID 33142018, PMID 33214082, PMID 33356421, PMID 33370024, PMID 33909232, PMID 33957442, PMID 34196693, PMID 34272087, PMID 34562230, PMID 34750990, PMID 34874751, PMID 34965890, PMID 34980020, PMID 35602670, PMID 36963200, PMID 37073741, PMID 37129197, PMID 37222189, PMID 37478389, PMID 37598723, PMID 38131628, PMID 38315963, PMID 39816915, PMID 39841295, PMID 39863139, PMID 39938471, PMID 39945382, PMID 40571483, PMID 40953502, PMID 41005671, PMID 41133726
U10CA180820 (10), U10CA180868 (8), P30CA033572 (5), U10CA180886 (4), U10CA180888 (4), U10CA180821 (3), 2015 (2), P30CA060553 (2), U10CA021115 (2), U10CA021661 (2), U10CA098543 (2), UM1CA186690 (2), N01CM62201 (1), P01CA084203 (1), P30CA015083 (1)