33 completed, 20 active not recruiting, 14 terminated, 9 recruiting. 35 Phase 1, 35 Phase 2, 12 Not applicable, 3 Phase 3, 1 Early Phase 1.
Follow Triple-Negative Breast Carcinoma: new trials by email Literature Review of Triple-Negative Breast Carcinoma trials Research Report on Triple-Negative Breast Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Vaccine (STEMVAC) for Improving Survival in Patients With Triple-Negative Breast Cancer and Moderate or Extensive Residual Cancer Burden CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine, Recombinant Granulocyte-Macrophage Colony-Stimulating Factor, Biospecimen Collection - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Not yet recruiting | University of Washington | 60 | 2026-11-01 | 2026-10-16 |
| US/PA/E Imaging for Early Identification of Tumor Response in Patients With Stage II-III Triple Negative Breast Cancer Receiving Neoadjuvant Immunotherapy and Chemotherapy Elastography, Magnetic Resonance Imaging, Photoacoustic Imaging - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Phase 2 | Not yet recruiting | Emory University | 32 | 2026-10-01 | 2026-10-07 |
| A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer Best Practice, Interview, Supportive Care - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Recruiting | City of Hope Medical Center | 126 | 2026-09-09 | 2026-10-16 |
| Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer Behavioral Intervention, Educational Intervention, Internet-Based Intervention - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Not applicable | Withdrawn | City of Hope Medical Center | 2026-07-16 | 2026-02-04 | |
| Circulating Tumor DNA Based Minimal Residual Disease Detection for Patients With Early-Stage Breast Cancer Biospecimen Collection, Electronic Health Record Review, Survey Administration - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Withdrawn | City of Hope Medical Center | 2026-05-12 | 2026-06-25 | |
| Neoadjuvant Darolutamide Alone or in Combination With Standard Therapy for Stage II-IIIA, AR+, TNBC Biospecimen Collection, Breast Biopsy Procedure, Carboplatin - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 2 | Recruiting | Vandana Abramson | 51 | 2025-09-09 | 2025-10-30 |
| Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer Biopsy of Breast, Biospecimen Collection, Breast Surgery - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 120 | 2025-05-14 | 2026-09-03 |
| Food for Thought - A Nutrition Intervention for Women Undergoing Active Treatment for Triple Negative Breast Cancer Biospecimen Collection, Cognitive Assessment, Dietary Intervention - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 60 | 2024-10-28 | 2025-12-11 |
| Access to Genetic Testing in Underserved Patients With Cancer Best Practice, Educational Intervention, Electronic Health Record Review - Breast Carcinoma, Male Breast Carcinoma | Not applicable | Recruiting | University of Southern California | 800 | 2023-10-24 | 2026-03-18 |
| Feasibility Study of Biobehavioral Stress Reduction Intervention in Patients With Triple Negative Breast Cancer Biospecimen Collection, Medical Chart Review, Stress Management Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 40 | 2022-12-14 | 2026-06-29 |
| STEMVAC in Patients With Early Stage Triple Negative Breast Cancer CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine, Sargramostim - Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | University of Washington | 33 | 2022-11-17 | 2026-07-23 |
| Precision Performance Status Assessment in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Behavioral Assessment, Electronic Health Record Review - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Terminated | M.D. Anderson Cancer Center | 27 | 2022-08-15 | 2024-08-26 | |
| Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer BET Bromodomain Inhibitor ZEN-3694, Binimetinib, Biopsy Procedure - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 42 | 2022-08-02 | 2026-10-14 |
| Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 138 | 2022-03-31 | 2026-08-20 |
| Panitumumab and Pembrolizumab in Combination With Neoadjuvant Chemotherapy for the Treatment of Stage III-IV Triple Negative Breast Cancer Carboplatin, Cyclophosphamide, Doxorubicin - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2022-03-11 | 2024-10-24 | |
| Mobile Health to Improve Oral Chemotherapy Adherence Among Women With Breast Cancer Best Practice, Informational Intervention, Medical Device Usage and Evaluation - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Not applicable | Completed | Emory University | 33 | 2021-10-22 | 2025-06-17 |
| Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer Cisplatin, Elimusertib, Gemcitabine Hydrochloride - Advanced Bile Duct Carcinoma, Advanced Breast Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 74 | 2021-08-25 | 2026-07-31 |
| Treatment Decision Making in African American Women Diagnosed With Triple Negative Breast Cancer Discussion, Interview, Survey Administration - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Completed | M.D. Anderson Cancer Center | 30 | 2021-05-03 | 2023-08-09 | |
| Nipple Aspirate Fluid in Detecting Breast Cancer Aspiration of Breast, Biospecimen Collection - Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8 | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 2 | 2020-12-10 | 2025-02-25 |
| National Cancer Institute "Cancer Moonshot Biobank" Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Acute Myeloid Leukemia, Anatomic Stage III Breast Cancer AJCC v8 | Active not recruiting | National Cancer Institute (NCI) | 1600 | 2020-11-11 | 2026-10-05 |
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Triple Negative Breast Neoplasms (86) · Breast Neoplasms (51) · Ovarian Neoplasms (13) · Carcinoma, Non-Small-Cell Lung (8) · Fallopian Tube Neoplasms (8) · Breast Neoplasms, Male (7) · Neoplasm Metastasis (7) · Melanoma (6) · Carcinoma, Renal Cell (5) · Inflammatory Breast Neoplasms (5) · Breast Carcinoma In Situ (4) · Lung Neoplasms (4) · Pancreatic Neoplasms (4) · Prostatic Neoplasms (4) · Squamous Cell Carcinoma of Head and Neck (4)
Breast Diseases (86) · Neoplasms (86) · Neoplasms by Site (86) · Skin Diseases (86) · Skin and Connective Tissue Diseases (86) · Breast Neoplasms (35) · Urogenital Diseases (18) · Urogenital Neoplasms (18) · Female Urogenital Diseases (17) · Female Urogenital Diseases and Pregnancy Complications (17) · Genital Diseases (16) · Endocrine Gland Neoplasms (15) · Endocrine System Diseases (15) · Genital Diseases, Female (15) · Neoplasms by Histologic Type (15)
Paclitaxel (18) · Taxes (18) · Carboplatin (15) · Specimen Handling (14) · pembrolizumab (13) · Doxorubicin (12) · Cyclophosphamide (11) · Magnetic Resonance Spectroscopy (9) · olaparib (5) · veliparib (5) · Capecitabine (4) · Colony-Stimulating Factors (4) · High-Energy Shock Waves (4) · Immunoglobulin G (4) · Interviews as Topic (4)
National Cancer Institute (NCI) (27) · M.D. Anderson Cancer Center (20) · City of Hope Medical Center (7) · Mayo Clinic (6) · Ohio State University Comprehensive Cancer Center (3) · University of Washington (3) · Emory University (2) · Northwestern University (2) · Vanderbilt-Ingram Cancer Center (2) · Academic and Community Cancer Research United (1) · Andrei Iagaru (1) · ECOG-ACRIN Cancer Research Group (1) · Jonsson Comprehensive Cancer Center (1) · Laura Huppert, MD, BA (1) · NRG Oncology (1)
United States (83) · Canada (4) · Puerto Rico (2) · South Africa (1)
Clinton Yam (5) · Anne Reb (2) · Shannon Puhalla (2) · Vandana Abramson, MD (2) · Alison M Schram (1) · Amulya C Yellala, MD (1) · Andrei M Iagaru, MD (1) · Aung Naing, MD (1) · Azadeh Nasrazad, MD,PHD (1) · Azadeh Nasrazadani (1) · Bhavana Pothuri (1) · Bhuvaneswari Ramaswamy, MD (1) · Bora Lim, MD (1) · Carlos E. Vargas, MD (1) · Carlos H Barcenas (1)
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P30CA016672 (4), UM1CA186709 (4), P30CA006516 (3), P30CA016058 (3), P30CA033572 (3), P30CA068485 (3), U01CA062490 (3), U01CA099168 (3), UM1CA186689 (3), UM1CA186712 (3), N01CM62204 (2), P30CA013330 (2), P30CA015083 (2), P30CA047904 (2), P30CA060553 (2)